Is castration leading to biological aging in dogs? Assessment of lipid peroxidation, inflammation, telomere length, mitochondrial DNA copy number, and expression of telomerase and age-related genes DOI Creative Commons
Hossein Hassanpour, Moosa Javdani,

Zahra Changaniyan-Khorasgani

et al.

BMC Veterinary Research, Journal Year: 2024, Volume and Issue: 20(1)

Published: Oct. 24, 2024

Biological aging is a complex process influenced by various factors, including reproductive status and castration. This study aimed to evaluate the impact of castration on biological in dogs. Fifteen male crossbred dogs were randomly divided into sham-operation control group (n = 5) castrated 10). Blood samples collected at weeks 0, 4, 8, 12, 16, 18 post-surgery. Malondialdehyde (MDA as indicator Lipid peroxidation), C-reactive protein (as an inflammation), telomere length, mitochondrial DNA (mtDNA) copy number, expression age-related (P16, P21, TBX2) telomerase-related (TERT) genes assessed blood samples. Plasma MDA levels higher 16 18, while CRP only week 18. Telomere length mtDNA number lower Gene analysis showed that P16 was 8 P21 TERT TBX2 The TBX2/P16 ratio but TBX2/P21 did not differ between groups. Castration appears have protective effect against dogs, evidenced lipid peroxidation, inflammation, changes gene expression.

Language: Английский

Involvement of SIRT1-mediated aging in liver diseases DOI Creative Commons
Yueming Zhang, Chang Gong, Lina Tao

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 20, 2025

Liver disease is a significant global health issue, responsible for millions of deaths annually. Aging, characterized by the gradual decline in cellular and physiological functions, impairs tissue regeneration, increases susceptibility to liver diseases, leads health. Silent information regulator 1 (SIRT1), NAD⁺-dependent deacetylase, has emerged as pivotal factor modulating age-related changes liver. SIRT1 preserves function regulating essential aging-related pathways, including telomere maintenance, epigenetic modifications, senescence, intercellular communication, inflammation, mitochondrial function. Notably, levels naturally with age, contributing progression increased vulnerability injury. This review summarizes regulatory role aging its impact on diseases such fibrosis, alcoholic associated (ALD), metabolic dysfunction-associated steatotic (MASLD), steatohepatitis (MASH), hepatocellular carcinoma (HCC). We also discuss emerging therapeutic approaches, activators, gene therapy, nutritional interventions, which are evaluated their potential restore mitigate progression. Finally, we highlight future research directions optimize SIRT1-targeted therapies clinical applications conditions.

Language: Английский

Citations

2
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways DOI
Alamusi Bayoude, Jiaxin Zhang, Ya Shen

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119400 - 119400

Published: Jan. 1, 2025

Language: Английский

Citations

1
Probiotic Limosilactobacillus reuteri DSM 17938 Alleviates Acute Liver Injury by Activating the AMPK Signaling via Gut Microbiota–Derived Propionate DOI
Yuting Zhao,

Weiqi Xie,

Jingyi Duan

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

1
Urolithin B as a renoprotective agent against 5-fluorouracil-induced nephrotoxicity: role of Nrf2/Keap1/HO-1, SIRT1/FOXO3, and NF-кB/TNF-α signaling pathways DOI
Mohammed W. Al-Rabia,

Hani Z. Asfour,

Rasha A. Mansouri

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 195, P. 115129 - 115129

Published: Nov. 22, 2024

Language: Английский

Citations

3
Sitagliptin regulates the AMPK/NF-κB signaling pathway to alleviate lipopolysaccharide-induced inflammatory responses and promote osteogenic differentiation in rat bone marrow mesenchymal stem cells DOI Creative Commons
Xi Yao, Min Liu, Pei Wang

et al.

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106253 - 106253

Published: April 1, 2025

This study aimed to explore the impact of sitagliptin on inflammatory response and osteogenic differentiation in lipopolysaccharide (LPS)-stimulated rat bone marrow mesenchymal stem cells (BMSCs) clarify underlying mechanisms action. In vitro-cultured BMSCs were identified, treated with a range doses, assessed cell counting kit-8 assay quantify viability. The expression proteins genes relevant inflammation osteogenesis was measured using enzyme-linked immunosorbent real-time quantitative polymerase chain reaction techniques. ability analyzed by alkaline phosphatase staining, activity assay, alizarin red s staining. Adenosine monophosphate-activated protein kinase (AMPK)/nuclear factor-kappa B (NF-κB) signaling pathway activation detected through western blotting. High but not low concentrations significantly suppressed cellular Sitagliptin dose-dependently inhibited LPS-induced responses while facilitating their differentiation. It also activated AMPK suppressing NF-κB activity. inhibitor treatment partially reversed these beneficial effects osteogenesis. suppresses promoting modulation AMPK/NF-κB activity, thereby mitigating functional impairment under microenvironmental conditions.

Language: Английский

Citations

0
Hepatoprotective Effects of Dandelion against AFB1-induced Liver Injury are Associated with Activation of Bile Acid-FXR Signaling in Chicks DOI
Zhe Peng, Jiang Deng,

Ze-Jing Xu

et al.

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108419 - 108419

Published: May 1, 2025

Language: Английский

Citations

0
Is castration leading to biological aging in dogs? Assessment of lipid peroxidation, inflammation, telomere length, mitochondrial DNA copy number, and expression of telomerase and age-related genes DOI Creative Commons
Hossein Hassanpour, Moosa Javdani,

Zahra Changaniyan-Khorasgani

et al.

BMC Veterinary Research, Journal Year: 2024, Volume and Issue: 20(1)

Published: Oct. 24, 2024

Biological aging is a complex process influenced by various factors, including reproductive status and castration. This study aimed to evaluate the impact of castration on biological in dogs. Fifteen male crossbred dogs were randomly divided into sham-operation control group (n = 5) castrated 10). Blood samples collected at weeks 0, 4, 8, 12, 16, 18 post-surgery. Malondialdehyde (MDA as indicator Lipid peroxidation), C-reactive protein (as an inflammation), telomere length, mitochondrial DNA (mtDNA) copy number, expression age-related (P16, P21, TBX2) telomerase-related (TERT) genes assessed blood samples. Plasma MDA levels higher 16 18, while CRP only week 18. Telomere length mtDNA number lower Gene analysis showed that P16 was 8 P21 TERT TBX2 The TBX2/P16 ratio but TBX2/P21 did not differ between groups. Castration appears have protective effect against dogs, evidenced lipid peroxidation, inflammation, changes gene expression.

Language: Английский

Citations

0