Taurine, an essential amino acid, attenuates rotenone-induced Parkinson’s disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release

Behavioural Brain Research, Год журнала: 2024, Номер 480, С. 115397 - 115397

Опубликована: Дек. 12, 2024

Язык: Английский

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Neurotherapeutic potential of sinapic acid in cerebellar neurotoxicity induced following excessive exposure to tramadol hydrochloride in male Sprague Dawley rats

Deleted Journal, Год журнала: 2025, Номер unknown, С. 200217 - 200217

Опубликована: Апрель 1, 2025

Язык: Английский

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Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 15, 2025

The vagus nerve (VN) is the primary parasympathetic nerve, providing two-way communication between body and brain through a network of afferent efferent fibers. Evidence suggests that altered VN signaling linked to changes in neuroimmune system, including microglia. Dysfunction microglia, resident innate immune cells brain, associated with various neurodevelopmental disorders, schizophrenia, attention deficit hyperactive disorder (ADHD), autism spectrum (ASD), epilepsy. While mechanistic understanding linking VN, disorders remains incomplete, stimulation (VNS) may provide better VN’s mechanisms act as possible treatment modality. In this review we examine important role modulating system inflammatory reflex, which involves cholinergic anti-inflammatory pathway, releases acetylcholine. Within central nervous (CNS), direct release acetylcholine can also be triggered by VNS. Homeostatic balance CNS notably maintained Microglia facilitate neurogenesis, oligodendrogenesis, astrogenesis, promote neuronal survival via trophic factor release. These monitor microenvironment complex sensome, groups receptors proteins enabling microglia modify health neurochemistry. Given limitations pharmacological interventions for seeks explore application VNS an intervention conditions. Accordingly, established action, e.g., modulation neurotransmitter pathways, well emerging preclinical clinical evidence supporting VNS’s impact on symptoms such those related inflammation induced infections. We discuss potential adapting non-invasive prevention these Overall, intended increase alleviating microglial dysfunction involved ADHD, ASD, Additionally, aim reveal new concepts field could serve understand development therapies disorders.

Язык: Английский

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Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats

BMC Pharmacology and Toxicology, Год журнала: 2025, Номер 26(1)

Опубликована: Апрель 14, 2025

Abstract Olanzapine, an atypical antipsychotic drug, is used to treat psychological diseases. However, it’s use carries common side effects. Those include weight gain, dyslipidemia, elevated glucose levels, and disrupted oxidative balance. We aimed test the effect of zinc coadministration lessen metabolic disturbances, inflammation stress in a rat model. Four treatment groups ( n = 6) were involved this investigation. Group 1 was control group (received no intervention). 2 received olanzapine (10 mg/kg, p.o.; daily) for six weeks, whereas Groups 3 4 50 mg/kg 100 sulphate (ZnSO ,p.o.; respectively, addition daily). Following completion, showed increased levels markers (GSSG, MDA, NO) impaired antioxidant (CAT, SOD, GSH). Further, strong positive correlation between insulin resistance index (HOMA-IR) IL-6, TNF-α, MDA liver. Insulin possible manifestation burden widespread inflammatory environment. In 4, however, ZnSO recovered each these dose-dependent manner. Improvements also noted other homeostatic markers, such as taurine, coenzyme Q10, ascorbic acid, vitamin E. Remarkably, both combination groups, there significant improvement all indicators dyslipidemia (triglycerides, total cholesterol) index. The biochemical study histological assessment liver slices agreed with results. Thus, results clearly suggest that Zinc supplementation can significantly improve stress, inflammation, perturbation (dyslipidemia resistance), injury caused by Albino rats.

Язык: Английский

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Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy

Journal of Molecular Neuroscience, Год журнала: 2024, Номер 74(4)

Опубликована: Ноя. 8, 2024

Язык: Английский

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Towards win-win electrochemical alternative for depolluting water and producing green H2: Understanding and unrevealing the participation of sacrificial organic compound on H2 production

International Journal of Hydrogen Energy, Год журнала: 2024, Номер 110, С. 598 - 608

Опубликована: Март 1, 2024

Язык: Английский

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