Taurine, an essential amino acid, attenuates rotenone-induced Parkinson’s disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release
Behavioural Brain Research,
Journal Year:
2024,
Volume and Issue:
480, P. 115397 - 115397
Published: Dec. 12, 2024
Language: Английский
Neurotherapeutic potential of sinapic acid in cerebellar neurotoxicity induced following excessive exposure to tramadol hydrochloride in male Sprague Dawley rats
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 200217 - 200217
Published: April 1, 2025
Language: Английский
Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation
Makenna Gargus,
No information about this author
Benneth Ben‐Azu,
No information about this author
Antonia Landwehr
No information about this author
et al.
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 15, 2025
The
vagus
nerve
(VN)
is
the
primary
parasympathetic
nerve,
providing
two-way
communication
between
body
and
brain
through
a
network
of
afferent
efferent
fibers.
Evidence
suggests
that
altered
VN
signaling
linked
to
changes
in
neuroimmune
system,
including
microglia.
Dysfunction
microglia,
resident
innate
immune
cells
brain,
associated
with
various
neurodevelopmental
disorders,
schizophrenia,
attention
deficit
hyperactive
disorder
(ADHD),
autism
spectrum
(ASD),
epilepsy.
While
mechanistic
understanding
linking
VN,
disorders
remains
incomplete,
stimulation
(VNS)
may
provide
better
VN’s
mechanisms
act
as
possible
treatment
modality.
In
this
review
we
examine
important
role
modulating
system
inflammatory
reflex,
which
involves
cholinergic
anti-inflammatory
pathway,
releases
acetylcholine.
Within
central
nervous
(CNS),
direct
release
acetylcholine
can
also
be
triggered
by
VNS.
Homeostatic
balance
CNS
notably
maintained
Microglia
facilitate
neurogenesis,
oligodendrogenesis,
astrogenesis,
promote
neuronal
survival
via
trophic
factor
release.
These
monitor
microenvironment
complex
sensome,
groups
receptors
proteins
enabling
microglia
modify
health
neurochemistry.
Given
limitations
pharmacological
interventions
for
seeks
explore
application
VNS
an
intervention
conditions.
Accordingly,
established
action,
e.g.,
modulation
neurotransmitter
pathways,
well
emerging
preclinical
clinical
evidence
supporting
VNS’s
impact
on
symptoms
such
those
related
inflammation
induced
infections.
We
discuss
potential
adapting
non-invasive
prevention
these
Overall,
intended
increase
alleviating
microglial
dysfunction
involved
ADHD,
ASD,
Additionally,
aim
reveal
new
concepts
field
could
serve
understand
development
therapies
disorders.
Language: Английский
Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats
BMC Pharmacology and Toxicology,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: April 14, 2025
Abstract
Olanzapine,
an
atypical
antipsychotic
drug,
is
used
to
treat
psychological
diseases.
However,
it’s
use
carries
common
side
effects.
Those
include
weight
gain,
dyslipidemia,
elevated
glucose
levels,
and
disrupted
oxidative
balance.
We
aimed
test
the
effect
of
zinc
coadministration
lessen
metabolic
disturbances,
inflammation
stress
in
a
rat
model.
Four
treatment
groups
(
n
=
6)
were
involved
this
investigation.
Group
1
was
control
group
(received
no
intervention).
2
received
olanzapine
(10
mg/kg,
p.o.;
daily)
for
six
weeks,
whereas
Groups
3
4
50
mg/kg
100
sulphate
(ZnSO
,p.o.;
respectively,
addition
daily).
Following
completion,
showed
increased
levels
markers
(GSSG,
MDA,
NO)
impaired
antioxidant
(CAT,
SOD,
GSH).
Further,
strong
positive
correlation
between
insulin
resistance
index
(HOMA-IR)
IL-6,
TNF-α,
MDA
liver.
Insulin
possible
manifestation
burden
widespread
inflammatory
environment.
In
4,
however,
ZnSO
recovered
each
these
dose-dependent
manner.
Improvements
also
noted
other
homeostatic
markers,
such
as
taurine,
coenzyme
Q10,
ascorbic
acid,
vitamin
E.
Remarkably,
both
combination
groups,
there
significant
improvement
all
indicators
dyslipidemia
(triglycerides,
total
cholesterol)
index.
The
biochemical
study
histological
assessment
liver
slices
agreed
with
results.
Thus,
results
clearly
suggest
that
Zinc
supplementation
can
significantly
improve
stress,
inflammation,
perturbation
(dyslipidemia
resistance),
injury
caused
by
Albino
rats.
Language: Английский
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Journal of Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
74(4)
Published: Nov. 8, 2024
Language: Английский
Towards win-win electrochemical alternative for depolluting water and producing green H2: Understanding and unrevealing the participation of sacrificial organic compound on H2 production
International Journal of Hydrogen Energy,
Journal Year:
2024,
Volume and Issue:
110, P. 598 - 608
Published: March 1, 2024
Language: Английский