The Science of The Total Environment, Год журнала: 2020, Номер 726, С. 138149 - 138149
Опубликована: Март 23, 2020
Язык: Английский
Water Research, Год журнала: 2020, Номер 181, С. 115942 - 115942
Опубликована: Май 16, 2020
Язык: Английский
Процитировано
1151
Environment International, Год журнала: 2020, Номер 139, С. 105689 - 105689
Опубликована: Апрель 4, 2020
Infectious diseases are acknowledged as one of the most critical threats to global public health today. Climate change, unprecedented population growth with accelerated rates antimicrobial resistance, have resulted in both emergence novel pathogenic organisms and re-emergence infections that were once controlled. The consequences led an increased vulnerability infectious globally. ability rapidly monitor spread is key for prevention, intervention control, however several limitations exist current surveillance systems capacity cope rapid environmental changes. Wastewater-Based Epidemiology (WBE) a new epidemiology tool has potential act complementary approach disease early warning system outbreaks. WBE postulates through analysis pooled wastewater, resistance spread, outbreak community level can be monitored comprehensively real-time. This manuscript provides overview status, well it introduces its recent advancements. It also recommendations further development required application effective surveillance.
Язык: Английский
Процитировано
583
The Science of The Total Environment, Год журнала: 2020, Номер 746, С. 141326 - 141326
Опубликована: Июль 28, 2020
Язык: Английский
Процитировано
466
Water Research, Год журнала: 2020, Номер 186, С. 116296 - 116296
Опубликована: Авг. 13, 2020
Wastewater-based epidemiology (WBE) has been used to analyze markers in wastewater treatment plant (WWTP) influent characterize emerging chemicals, drug use patterns, or disease spread within communities. This approach can be particularly helpful understanding outbreaks of like the novel Coronavirus disease-19 (COVID-19) when combined with clinical datasets. In this study, three RT-ddPCR assays (N1, N2, N3) were detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA weekly samples from nine WWTPs southeastern Virginia. first several weeks sampling, SARS-CoV-2 detections sporadic. Frequency and overall concentrations increased mid March into late July. During twenty-one week ranged 101 104 copies 100 mL-1 where viral was detected. Fluctuations population normalized loading rates WWTP service areas agreed known during study. Here we propose ways that data presented spatially temporally greatest public health officials. As COVID-19 pandemic wanes, it is likely communities will see incidence small, localized outbreaks. these instances, WBE could as a pre-screening tool better target testing needs limited resources.
Язык: Английский
Процитировано
448
The Science of The Total Environment, Год журнала: 2020, Номер 751, С. 141750 - 141750
Опубликована: Авг. 18, 2020
Язык: Английский
Процитировано
399
Water Research, Год журнала: 2020, Номер 186, С. 116404 - 116404
Опубликована: Сен. 9, 2020
The presence of SARS-CoV-2 in the feces infected patients and wastewater has drawn attention, not only to possibility fecal-oral transmission but also use as an epidemiological tool. COVID-19 pandemic highlighted problems evaluating scope disease using classical surveillance approaches, due a lack diagnostic capacity, their application small proportion population. As previous pandemics, statistics, particularly population infected, are believed be widely underestimated. Furthermore, analysis clinical samples cannot predict outbreaks timely manner or easily capture asymptomatic carriers. Threfore, community-scale surveillance, including wastewater-based epidemiology, can bridge broader community clinic, becoming valuable indirect prediction tool for other viruses. This article summarizes current knowledge discusses critical factors implementing epidemiology COVID-19.
Язык: Английский
Процитировано
372
ACS Nano, Год журнала: 2020, Номер 14(7), С. 7783 - 7807
Опубликована: Июнь 18, 2020
Biosensors and nanoscale analytical tools have shown huge growth in literature the past 20 years, with a large number of reports on topic 'ultrasensitive', 'cost-effective', 'early detection' potential 'mass-production' cited web science. Yet none these are commercially available market or practically viable for mass production use pandemic diseases such as coronavirus disease 2019 (COVID-19). In this context, we review technological challenges opportunities current bio/chemical sensors by critically analyzing bottlenecks which hindered implementation advanced sensing technologies diseases. We also describe brief COVID-19 comparing it other strains that severe acute respiratory syndrome (SARS) Middle East (MERS) identification features enable biosensing. Moreover, discuss visualization characterization can potentially be used not only applications but to assist speeding up drug discovery vaccine development process. Furthermore, emerging monitoring mechanism, namely wastewater-based epidemiology, early warning outbreak, focusing rapid on-site analysis SARS-CoV2 sewage. To conclude, provide holistic insights into associated quick translation technologies, policies, ethical issues, technology adoption, an overall outlook role pandemics.
Язык: Английский
Процитировано
345
The Science of The Total Environment, Год журнала: 2018, Номер 649, С. 247 - 263
Опубликована: Авг. 23, 2018
Язык: Английский
Процитировано
299
Case Studies in Chemical and Environmental Engineering, Год журнала: 2020, Номер 1, С. 100006 - 100006
Опубликована: Апрель 30, 2020
This article discusses the potential ramifications of COVID-19 pandemic on waste and wastewater services, focusing critical points where alternative operating procedures or additional mitigation measures may be advisable. Key concerns are (i) long half-life virus materials such as containers, bags, in wastewater, (ii) possible transmission via contaminated surfaces aerosols from systems. There opportunities to further science wastewater-based epidemiology by monitoring viral RNA assess disease prevalence spread defined populations, which prove beneficial for informing related public health policy.
Язык: Английский
Процитировано
271
The Science of The Total Environment, Год журнала: 2021, Номер 782, С. 146749 - 146749
Опубликована: Март 30, 2021
The COVID-19 pandemic has been a source of ongoing challenges and presents an increased risk illness in group environments, including jails, long-term care facilities, schools, residential college campuses. Early reports that the SARS-CoV-2 virus was detectable wastewater advance confirmed cases sparked widespread interest wastewater-based epidemiology (WBE) as tool for mitigation outbreaks. One hypothesis surveillance might provide cost-effective alternative to other more expensive approaches such pooled random testing groups. In this paper, we report outcomes pilot program at University North Carolina Charlotte, large urban university with substantial population students living on-campus dormitories. Surveillance conducted building level on thrice-weekly schedule throughout university's fall semester. multiple cases, enabled identification asymptomatic were not detected by components campus monitoring program, which also included in-house contact tracing, symptomatic testing, scheduled student athletes, daily symptom reporting. context all cluster events reported community during semester, resulted smaller clusters than types events. Wastewater able detect single individuals dorms resident populations 150-200. While strategy described developed COVID-19, it is likely be applicable future pandemics universities group-living environments.
Язык: Английский
Процитировано
241