Eu-MOF based fluorescence probe for ratiometric and visualization detection of Cu2+

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2023, Номер 304, С. 123367 - 123367

Опубликована: Сен. 6, 2023

Язык: Английский

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Rational Design of Organelle-Targeted Fluorescent Probes: Insights from Artificial Intelligence

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Monitoring the physiological changes of organelles is essential for understanding local biological information cells and improving diagnosis therapy diseases. Currently, fluorescent probes are considered as most powerful tools imaging have been widely applied in biomedical fields. However, expected targeting effects these often inconsistent with real experiments. The design mainly depends on empirical knowledge researchers, which was inhibited by limited chemical space low efficiency. Herein, we proposed a novel multilevel framework prediction organelle-targeted employing advanced artificial intelligence algorithms. In this way, not only mechanism could be interpreted beyond intuitions but also quick evaluation method established rational design. Furthermore, powers optimized synthesized based methodology were verified quantitative calculation

Язык: Английский

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The development of biosensors for alkaline phosphatase activity detection based on a phosphorylated DNA probe

Talanta, Год журнала: 2024, Номер 270, С. 125622 - 125622

Опубликована: Янв. 11, 2024

Язык: Английский

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Biosensors; a novel concept in real-time detection of autophagy

Biosensors and Bioelectronics, Год журнала: 2024, Номер 254, С. 116204 - 116204

Опубликована: Март 16, 2024

Язык: Английский

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Alkaline Phosphatase-Triggered Etching of Au@FeOOH Nanoparticles for Enzyme Level Assay under Dark-Field Microscopy

Analytical Chemistry, Год журнала: 2021, Номер 93(30), С. 10727 - 10734

Опубликована: Июль 23, 2021

In clinical diagnosis, the level of biological enzymes in serum has been generally regarded as markers human diseases. this work, a kind simple and sensitive plasmonic probe (indicated Au@FeOOH) synthesized with guidance imaging subsequently developed for alkaline phosphatase (ALP) detection under dark-field microscopy (DFM). As hydrolysis enzyme, ALP can promote l-ascorbic acid 2-phosphate to ascorbic (AA). AA further acts strong reduction reagent decomposition FeOOH shell, which results blue shift localized surface plasmon resonance spectra an obvious color change DFM. RGB analyses show that using ΔR/G value instead scattering wavelength or R/G analytical signal, deviation attributed size distribution initial Au NPs is greatly suppressed, linear range from 0.2 6.0 U/L (R2 = 0.99) limit 0.06 are acquired various concentrations during detection. Besides, approach exhibits excellent selectivity complex samples, expected be applied early diagnosis diseases by monitoring biomarkers future.

Язык: Английский

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A phenothiazine coumarin based ratiometric fluorescent probe for real-time detection of lysosomal hypochlorite in living cell and zebra fish

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2021, Номер 261, С. 120024 - 120024

Опубликована: Май 26, 2021

Язык: Английский

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Responsive photonic alginate hydrogel particles for the quantitative detection of alkaline phosphatase

NPG Asia Materials, Год журнала: 2022, Номер 14(1)

Опубликована: Июнь 24, 2022

Abstract Alkaline phosphatase (ALP) is an important marker for many diseases, yet efficient and reliable detection method still lacking. Here, we present a novel photonic alginate hydrogel particle as ALP sensor based on the competitive combination of intermediary agent, pyrophosphate ion (PPi), with crosslinker, which can trigger phase-transition response from hydrogel. This be converted into dual optical readouts, fluorescence signal structural color signal. Quantitative determination was established this dual-indicator system high accuracy reliability. These features suggest potential ideal applications responsive particles to detect other macromolecules.

Язык: Английский

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Fluorescent filter paper with pH-responsive carbon dots for the on-site detection of biogenic amines in food

New Journal of Chemistry, Год журнала: 2023, Номер 47(16), С. 7588 - 7594

Опубликована: Янв. 1, 2023

A ratiometric fluorescent sensor for eight kinds of biogenic amines was established by facile mixing pH-responsive carbon dots and Rhodamine B.

Язык: Английский

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A fluorescent optical fiber sensor for real-time, portable detection of alkaline phosphatase activity

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137568 - 137568

Опубликована: Март 1, 2025

Язык: Английский

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Constructing a novel fluorescence detection method for γ-glutamyltranspeptidase and application on visualizing liver injury

Biosensors and Bioelectronics, Год журнала: 2022, Номер 219, С. 114767 - 114767

Опубликована: Сен. 30, 2022

Язык: Английский

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