Abstract
Thermoelectrics
(TEs),
enabling
the
direct
conversion
between
heat
and
electrical
energy,
have
demonstrated
extensive
application
potential
in
biomedical
fields.
Herein,
mechanism
of
TE
effect,
recent
developments
materials,
biocompatibility
assessment
materials
are
provided.
In
addition
to
fundamentals
TEs,
a
timely
comprehensive
review
progress
advanced
their
applications
is
presented,
including
wearable
power
generation,
personal
thermal
management,
biosensing.
addition,
new‐emerged
medical
wound
healing,
disease
treatment,
antimicrobial
therapy,
anti‐cancer
therapy
thoroughly
reviewed.
Finally,
main
challenges
future
possibilities
outlined
for
TEs
fields,
as
well
material
selection
criteria
specific
scenarios.
Together,
these
advancements
can
provide
innovative
insights
into
development
broader
Journal of Clinical Microbiology,
Год журнала:
2022,
Номер
60(10)
Опубликована: Июль 19, 2022
Nearly
40
years
have
elapsed
since
the
invention
of
PCR,
with
its
extremely
sensitive
and
specific
ability
to
detect
nucleic
acids
via
in
vitro
enzyme-mediated
amplification.
In
turn,
more
than
2
passed
onset
coronavirus
disease
2019
(COVID-19)
pandemic,
during
which
time
molecular
diagnostics
for
infectious
diseases
assumed
a
larger
global
role
ever
before.
Military Medical Research,
Год журнала:
2022,
Номер
9(1)
Опубликована: Март 18, 2022
Abstract
Traditional
diagnostic
strategies
for
infectious
disease
detection
require
benchtop
instruments
that
are
inappropriate
point-of-care
testing
(POCT).
Emerging
microfluidics,
a
highly
miniaturized,
automatic,
and
integrated
technology,
potential
substitute
traditional
methods
in
performing
rapid,
low-cost,
accurate,
on-site
diagnoses.
Molecular
diagnostics
widely
used
microfluidic
devices
as
the
most
effective
approaches
pathogen
detection.
This
review
summarizes
latest
advances
microfluidics-based
molecular
diseases
from
academic
perspectives
industrial
outlooks.
First,
we
introduce
typical
on-chip
nucleic
acid
processes,
including
sample
preprocessing,
amplification,
signal
read-out.
Then,
four
categories
of
platforms
compared
with
respect
to
features,
merits,
demerits.
We
further
discuss
application
digital
assay
absolute
quantification.
Both
classic
recent
commercial
summarized
proof
current
market
status.
Finally,
propose
future
directions
diagnosis.
ECS Sensors Plus,
Год журнала:
2024,
Номер
3(1), С. 011601 - 011601
Опубликована: Март 1, 2024
There
is
a
plethora
of
electrochemical
biosensors
developed
for
ultrasensitive
detection
clinically
relevant
biomarkers.
However,
many
these
systems
lose
their
performance
in
heterogeneous
clinical
samples
and
are
too
complex
to
be
operated
by
end
users
at
the
point-of-care
(POC),
prohibiting
commercial
success.
Integration
with
sample
processing
technology
addresses
both
challenges;
however,
it
adds
manufacturing
complexity
overall
cost
systems.
Herein,
we
review
different
components
biosensor
avenues
creating
fully
integrated
In
context
integration,
focus
on
discussing
trade-offs
between
sensing
performance,
cost,
scalable
guide
readers
toward
designing
new
commercialization
potential.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(16)
Опубликована: Фев. 26, 2024
Bacterial
infections
have
emerged
as
the
leading
causes
of
mortality
and
morbidity
worldwide.
Herein,
we
developed
a
dual-channel
fluorescence
"turn-on"
sensor
array,
comprising
six
electrostatic
complexes
formed
from
one
negatively
charged
poly(para-aryleneethynylene)
(PPE)
positively
aggregation-induced
emission
(AIE)
fluorophores.
The
6-element
array
enabled
simultaneous
identification
20
bacteria
(OD
Transforming
lab
research
into
a
sustainable
business
is
becoming
trend
in
the
microfluidic
field.
However,
there
are
various
challenges
during
translation
process
due
to
gaps
between
academia
and
industry,
especially
from
laboratory
prototyping
industrial
scale-up
production,
which
critical
for
potential
commercialization.
In
this
Perspective,
based
on
our
experience
collaboration
with
stakeholders,
e.g.,
biologists,
engineers,
diagnostic
specialists,
manufacturers,
we
aim
share
understanding
of
manufacturing
chain
cartridge
concept
development
where
production
commercial
cartridges
highlighted.
Four
suggestions
aspect
design
manufacturing,
professional
involvement,
material
selection,
standardization
provided
order
help
scientists
bring
their
innovations
pre-clinical,
clinical,
mass
improve
manufacturability
prototypes
toward
Biosensors,
Год журнала:
2023,
Номер
13(6), С. 584 - 584
Опубликована: Май 27, 2023
Conventional
diagnostic
techniques
are
based
on
the
utilization
of
analyte
sampling,
sensing
and
signaling
separate
platforms
for
detection
purposes,
which
must
be
integrated
to
a
single
step
procedure
in
point
care
(POC)
testing
devices.
Due
expeditious
nature
microfluidic
platforms,
trend
has
been
shifted
toward
implementation
these
systems
analytes
biochemical,
clinical
food
technology.
Microfluidic
molded
with
substances
such
as
polymers
or
glass
offer
specific
sensitive
infectious
noninfectious
diseases
by
providing
innumerable
benefits,
including
less
cost,
good
biological
affinity,
strong
capillary
action
simple
process
fabrication.
In
case
nanosensors
nucleic
acid
detection,
some
challenges
need
addressed,
cellular
lysis,
isolation
amplification
before
its
detection.
To
avoid
laborious
steps
executing
processes,
advances
have
deployed
this
perspective
on-chip
sample
preparation,
introduction
an
emerging
field
modular
microfluidics
that
multiple
advantages
over
microfluidics.
This
review
emphasizes
significance
technology
non-infectious
diseases.
The
isothermal
conjunction
lateral
flow
assay
greatly
increases
binding
efficiency
nanoparticles
biomolecules
improves
limit
sensitivity.
Most
importantly,
deployment
paper-based
material
made
cellulose
reduces
overall
cost.
discussed
explicating
applications
different
fields.
Next-generation
methods
can
improved
using
CRISPR/Cas
systems.
concludes
comparison
future
prospects
various
systems,
plasma
separation
used
ACS Nano,
Год журнала:
2023,
Номер
17(7), С. 6507 - 6518
Опубликована: Март 27, 2023
Point-of-care
real-time
reverse-transcription
polymerase
chain
reaction
(RT-PCR)
facilitates
the
widespread
use
of
rapid,
accurate,
and
cost-effective
near-patient
testing
that
is
available
to
public.
Here,
we
report
ultrafast
plasmonic
nucleic
acid
amplification
quantification
for
decentralized
molecular
diagnostics.
The
RT-PCR
system
features
an
thermocycler
(PTC),
a
disposable
plastic-on-metal
(PoM)
cartridge,
ultrathin
microlens
array
fluorescence
(MAF)
microscope.
PTC
provides
photothermal
cycling
under
white-light-emitting
diode
illumination
precise
temperature
monitoring
with
integrated
resistance
detector.
PoM
thin
film
cartridge
allows
rapid
heat
transfer
as
well
complete
light
blocking
from
excitation
source,
resulting
in
highly
efficient
PCR
quantification.
Besides,
MAF
microscope
exhibits
close-up
high-contrast
microscopic
imaging.
All
systems
were
fully
packaged
palm
size
point-of-care
testing.
demonstrates
diagnosis
coronavirus
disease-19
RNA
virus
within
10
min
yields
95.6%
efficiency,
96.6%
classification
accuracy
preoperational
test,
91%
total
percent
agreement
clinical
diagnostic
test.
compact
can
decentralize
primary
care
developing
countries.
