Abstract
Thermoelectrics
(TEs),
enabling
the
direct
conversion
between
heat
and
electrical
energy,
have
demonstrated
extensive
application
potential
in
biomedical
fields.
Herein,
mechanism
of
TE
effect,
recent
developments
materials,
biocompatibility
assessment
materials
are
provided.
In
addition
to
fundamentals
TEs,
a
timely
comprehensive
review
progress
advanced
their
applications
is
presented,
including
wearable
power
generation,
personal
thermal
management,
biosensing.
addition,
new‐emerged
medical
wound
healing,
disease
treatment,
antimicrobial
therapy,
anti‐cancer
therapy
thoroughly
reviewed.
Finally,
main
challenges
future
possibilities
outlined
for
TEs
fields,
as
well
material
selection
criteria
specific
scenarios.
Together,
these
advancements
can
provide
innovative
insights
into
development
broader
Micromachines,
Год журнала:
2023,
Номер
14(3), С. 658 - 658
Опубликована: Март 15, 2023
The
polymerase
chain
reaction
(PCR)
is
essential
in
nucleic
acid
amplification
tests
and
widely
used
many
applications
such
as
infectious
disease
detection,
tumor
screening,
food
safety
testing;
however,
most
PCR
devices
have
inefficient
heating
cooling
ramp
rates
for
the
solution,
which
significantly
limit
their
application
special
scenarios
hospital
emergencies,
airports,
customs.
Here,
we
propose
a
temperature
control
strategy
to
increase
solution
by
switching
microfluidic
chips
between
multiple
zones
excessively
increasing
difference
solution;
accordingly,
designed
an
ultrafast
thermocycler.
results
showed
that
of
are
linear
function
differences
within
range,
larger
would
result
faster
rates.
maximum
25
μL
reached
24.12
°C/s
25.28
°C/s,
respectively,
average
rate
was
13.33
6-8
times
higher
than
conventional
commercial
devices.
thermocycler
achieved
9
min
(1
pre-denaturation
+
45
cycles)
amplification,
shortening
time
92%
compared
120
has
potential
be
rapid
detection.
Biosensors and Bioelectronics,
Год журнала:
2023,
Номер
246, С. 115830 - 115830
Опубликована: Ноя. 16, 2023
The
limit
of
detection
(LOD),
speed,
and
cost
crucial
COVID-19
diagnostic
tools,
including
lateral
flow
assays
(LFA),
enzyme-linked
immunosorbent
(ELISA),
polymerase
chain
reactions
(PCR),
have
all
improved
because
the
financial
governmental
support
for
epidemic.
most
notable
improvement
in
overall
efficiency
among
them
has
been
seen
with
PCR.
Its
significance
human
health
increased
during
pandemic,
when
it
emerged
as
commonly
used
approach
identifying
virus.
However,
problems
complexity,
expense,
PCR
deployment
point-of-care
settings
continues
to
be
difficult.
Microfluidic
platforms
offer
a
promising
solution
by
enabling
development
smaller,
more
affordable,
faster
systems.
In
this
review,
we
delve
into
engineering
challenges
associated
advancement
high-speed
microfluidic
equipment.
We
introduce
criteria
that
facilitate
evaluation
comparison
factors
such
LOD,
cycling
efficiency,
multiplexing
capacity,
considering
sample
volume,
fluidics,
reactor
geometry
materials,
well
heating/cooling
methods.
also
provide
comprehensive
list
commercially
available
devices
conclude
projections
discussion
regarding
current
obstacles
need
addressed
order
progress
further
field.
Biosensors,
Год журнала:
2023,
Номер
13(2), С. 163 - 163
Опубликована: Янв. 20, 2023
Spread
of
coronavirus
disease
2019
(COVID-19)
has
significantly
impacted
the
public
health
and
economic
sectors.
It
is
urgently
necessary
to
develop
rapid,
convenient,
cost-effective
point-of-care
testing
(POCT)
technologies
for
early
diagnosis
control
plague’s
transmission.
Developing
POCT
methods
related
devices
critical
achieving
diagnosis.
With
advantages
miniaturization,
high
throughput,
small
sample
requirements,
low
actual
consumption,
microfluidics
an
essential
technology
development
devices.
In
this
review,
according
different
driving
forces
fluid,
we
introduce
common
based
on
microfluidic
market,
including
paper-based
microfluidic,
centrifugal
optical
digital
platforms.
Furthermore,
various
microfluidic-based
assays
diagnosing
COVID-19
are
summarized,
immunoassays,
such
as
ELISA,
molecular
assays,
PCR.
Finally,
challenges
future
perspectives
device
design
presented.
The
ultimate
goals
paper
provide
new
insights
directions
diagnostics
while
expecting
contribute
COVID-19.
Biosensors,
Год журнала:
2023,
Номер
13(7), С. 732 - 732
Опубликована: Июль 14, 2023
Pathogenic
pathogens
invade
the
human
body
through
various
pathways,
causing
damage
to
host
cells,
tissues,
and
their
functions,
ultimately
leading
development
of
diseases
posing
a
threat
health.
The
rapid
accurate
detection
pathogenic
in
humans
is
crucial
pressing.
Nucleic
acid
offers
advantages
such
as
higher
sensitivity,
accuracy,
specificity
compared
antibody
antigen
methods.
However,
conventional
nucleic
testing
time-consuming,
labor-intensive,
requires
sophisticated
equipment
specialized
medical
personnel.
Therefore,
this
review
focuses
on
advanced
systems
that
aim
address
issues
time,
portability,
degree
automation,
cross-contamination.
These
include
extraction-free
testing,
fully
automated
extraction,
amplification,
detection,
well
enclosed
commercial
equipment.
Additionally,
biochemical
methods
used
for
are
briefly
described.
We
hope
will
inspire
further
research
more
suitable
reagents
devices
rapid,
point-of-care
diagnostics.
Abstract
Thermoelectrics
(TEs),
enabling
the
direct
conversion
between
heat
and
electrical
energy,
have
demonstrated
extensive
application
potential
in
biomedical
fields.
Herein,
mechanism
of
TE
effect,
recent
developments
materials,
biocompatibility
assessment
materials
are
provided.
In
addition
to
fundamentals
TEs,
a
timely
comprehensive
review
progress
advanced
their
applications
is
presented,
including
wearable
power
generation,
personal
thermal
management,
biosensing.
addition,
new‐emerged
medical
wound
healing,
disease
treatment,
antimicrobial
therapy,
anti‐cancer
therapy
thoroughly
reviewed.
Finally,
main
challenges
future
possibilities
outlined
for
TEs
fields,
as
well
material
selection
criteria
specific
scenarios.
Together,
these
advancements
can
provide
innovative
insights
into
development
broader
