Thermoelectric Materials and Devices for Advanced Biomedical Applications DOI

Shiyu Jia,

Huangshui Ma,

Shaojingya Gao

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 11, 2024

Abstract Thermoelectrics (TEs), enabling the direct conversion between heat and electrical energy, have demonstrated extensive application potential in biomedical fields. Herein, mechanism of TE effect, recent developments materials, biocompatibility assessment materials are provided. In addition to fundamentals TEs, a timely comprehensive review progress advanced their applications is presented, including wearable power generation, personal thermal management, biosensing. addition, new‐emerged medical wound healing, disease treatment, antimicrobial therapy, anti‐cancer therapy thoroughly reviewed. Finally, main challenges future possibilities outlined for TEs fields, as well material selection criteria specific scenarios. Together, these advancements can provide innovative insights into development broader

Язык: Английский

Ultrafast Microfluidic PCR Thermocycler for Nucleic Acid Amplification DOI Creative Commons

Yiquan An,

Shaolei Huang,

Bangchao Xi

и другие.

Micromachines, Год журнала: 2023, Номер 14(3), С. 658 - 658

Опубликована: Март 15, 2023

The polymerase chain reaction (PCR) is essential in nucleic acid amplification tests and widely used many applications such as infectious disease detection, tumor screening, food safety testing; however, most PCR devices have inefficient heating cooling ramp rates for the solution, which significantly limit their application special scenarios hospital emergencies, airports, customs. Here, we propose a temperature control strategy to increase solution by switching microfluidic chips between multiple zones excessively increasing difference solution; accordingly, designed an ultrafast thermocycler. results showed that of are linear function differences within range, larger would result faster rates. maximum 25 μL reached 24.12 °C/s 25.28 °C/s, respectively, average rate was 13.33 6-8 times higher than conventional commercial devices. thermocycler achieved 9 min (1 pre-denaturation + 45 cycles) amplification, shortening time 92% compared 120 has potential be rapid detection.

Язык: Английский

Процитировано

17

A roadmap to high-speed polymerase chain reaction (PCR): COVID-19 as a technology accelerator DOI Creative Commons
Masoud Madadelahi,

Rahul Agarwal,

Sergio O. Martínez‐Chapa

и другие.

Biosensors and Bioelectronics, Год журнала: 2023, Номер 246, С. 115830 - 115830

Опубликована: Ноя. 16, 2023

The limit of detection (LOD), speed, and cost crucial COVID-19 diagnostic tools, including lateral flow assays (LFA), enzyme-linked immunosorbent (ELISA), polymerase chain reactions (PCR), have all improved because the financial governmental support for epidemic. most notable improvement in overall efficiency among them has been seen with PCR. Its significance human health increased during pandemic, when it emerged as commonly used approach identifying virus. However, problems complexity, expense, PCR deployment point-of-care settings continues to be difficult. Microfluidic platforms offer a promising solution by enabling development smaller, more affordable, faster systems. In this review, we delve into engineering challenges associated advancement high-speed microfluidic equipment. We introduce criteria that facilitate evaluation comparison factors such LOD, cycling efficiency, multiplexing capacity, considering sample volume, fluidics, reactor geometry materials, well heating/cooling methods. also provide comprehensive list commercially available devices conclude projections discussion regarding current obstacles need addressed order progress further field.

Язык: Английский

Процитировано

16

Microfluidics for COVID-19: From Current Work to Future Perspective DOI Creative Commons
Qi Li, Xingchen Zhou, Qian Wang

и другие.

Biosensors, Год журнала: 2023, Номер 13(2), С. 163 - 163

Опубликована: Янв. 20, 2023

Spread of coronavirus disease 2019 (COVID-19) has significantly impacted the public health and economic sectors. It is urgently necessary to develop rapid, convenient, cost-effective point-of-care testing (POCT) technologies for early diagnosis control plague’s transmission. Developing POCT methods related devices critical achieving diagnosis. With advantages miniaturization, high throughput, small sample requirements, low actual consumption, microfluidics an essential technology development devices. In this review, according different driving forces fluid, we introduce common based on microfluidic market, including paper-based microfluidic, centrifugal optical digital platforms. Furthermore, various microfluidic-based assays diagnosing COVID-19 are summarized, immunoassays, such as ELISA, molecular assays, PCR. Finally, challenges future perspectives device design presented. The ultimate goals paper provide new insights directions diagnostics while expecting contribute COVID-19.

Язык: Английский

Процитировано

15

Advances in Simple, Rapid, and Contamination-Free Instantaneous Nucleic Acid Devices for Pathogen Detection DOI Creative Commons
Yue Wang, Chengming Wang, Zepeng Zhou

и другие.

Biosensors, Год журнала: 2023, Номер 13(7), С. 732 - 732

Опубликована: Июль 14, 2023

Pathogenic pathogens invade the human body through various pathways, causing damage to host cells, tissues, and their functions, ultimately leading development of diseases posing a threat health. The rapid accurate detection pathogenic in humans is crucial pressing. Nucleic acid offers advantages such as higher sensitivity, accuracy, specificity compared antibody antigen methods. However, conventional nucleic testing time-consuming, labor-intensive, requires sophisticated equipment specialized medical personnel. Therefore, this review focuses on advanced systems that aim address issues time, portability, degree automation, cross-contamination. These include extraction-free testing, fully automated extraction, amplification, detection, well enclosed commercial equipment. Additionally, biochemical methods used for are briefly described. We hope will inspire further research more suitable reagents devices rapid, point-of-care diagnostics.

Язык: Английский

Процитировано

15

Thermoelectric Materials and Devices for Advanced Biomedical Applications DOI

Shiyu Jia,

Huangshui Ma,

Shaojingya Gao

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 11, 2024

Abstract Thermoelectrics (TEs), enabling the direct conversion between heat and electrical energy, have demonstrated extensive application potential in biomedical fields. Herein, mechanism of TE effect, recent developments materials, biocompatibility assessment materials are provided. In addition to fundamentals TEs, a timely comprehensive review progress advanced their applications is presented, including wearable power generation, personal thermal management, biosensing. addition, new‐emerged medical wound healing, disease treatment, antimicrobial therapy, anti‐cancer therapy thoroughly reviewed. Finally, main challenges future possibilities outlined for TEs fields, as well material selection criteria specific scenarios. Together, these advancements can provide innovative insights into development broader

Язык: Английский

Процитировано

6