Single‐Atomic Iron Doped Carbon Dots with Both Photoluminescence and Oxidase‐Like Activity

Small, Год журнала: 2022, Номер 18(37)

Опубликована: Авг. 19, 2022

Abstract Multifunctional nanozymes can benefit biochemical analysis via expanding sensing modes and enhancing analytical performance, but designing multifunctional to realize the desired of targets is challenging. In this work, single‐atomic iron doped carbon dots (SA Fe‐CDs) are designed synthesized a facile in situ pyrolysis process. The small‐sized CDs not only maintain their tunable fluorescence, also serve as support for loading dispersed active sites. Monoatomic Fe offers SA Fe‐CDs exceptional oxidase‐mimetic activity catalyze 3,3′,5,5′‐tetramethylbenzidine (TMB) oxidation with fast response ( V max = 10.4 nM s ‐1 ) strong affinity K m 168 µM). Meanwhile, photoluminescence quenched by product TMB due inner filter effect. Phosphate ions (Pi) suppress oxidase‐mimicking restore interacting Based on principle, dual‐mode colorimetric fluorescence assay Pi high sensitivity, selectivity, rapid established. This work paves path develop enzyme‐like catalysts, simple efficient method phosphate monitoring, which will inspire exploration multi‐mode strategies based nanozyme catalysis.

Язык: Английский

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Recent advances in the development and analytical applications of oxidase-like nanozymes

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 166, С. 117220 - 117220

Опубликована: Авг. 3, 2023

Язык: Английский

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Facile molecular imprinting on magnetic nanozyme surface for highly selective colorimetric detection of tetracycline

Sensors and Actuators B Chemical, Год журнала: 2022, Номер 370, С. 132451 - 132451

Опубликована: Июль 30, 2022

Язык: Английский

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Bimetal Biomimetic Engineering Utilizing Metal–Organic Frameworks for Superoxide Dismutase Mimic

ACS Materials Letters, Год журнала: 2022, Номер 4(4), С. 751 - 757

Опубликована: Март 23, 2022

In the past decade, scientists sought to engineer nanomaterials with natural enzymes-like biological function, and searched for newfangled applications. Herein, we show first example of utilizing a bimetal metal–organic framework (MOF-818) platform mimicking Cu/Zn-superoxide dismutase (Cu/Zn-SOD), an important antioxidant enzyme that specifically scavenges superoxide anions. Experimental data theoretical calculations reveal high Cu/Zn-SOD-like activity MOF-818 results from synergistic catalysis, which is analogous Cu/Zn-SOD. Such biomimetic process allows much higher SOD-like activity, compared reported monometallic MOFs mimics. Moreover, displays excellent stability against heating, organic solvents, denaturant treatments, should inactivate enzymes. Based on catalytic mechanism, also construct MOF-818-based colorimetric sensing phosphorylated peptides proteins detection. This work provides new insight engineering, may expedite scale-up applications nanozymes in various fields.

Язык: Английский

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Oxidase-like Nanozyme Activity of Manganese Metal–Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of l-Cysteine

ACS Applied Nano Materials, Год журнала: 2023, Номер 6(9), С. 8036 - 8045

Опубликована: Май 3, 2023

The utilization of ultrathin Mn-metal–organic framework (Mn-UMOF) nanosheets for oxidase-like nanozyme activity has been demonstrated. Mn-UMOF exhibited superior to oxidize chromogenic TMB and ABTS than the bulk Mn-BMOF. Based on this fact, a platform colorimetric sensing l-cysteine (l-cys) established over detection other amino acids natural compounds such as urea glucose. In addition, capability catalyzing oxidation amplex red fluorescent first oxidized product, which used develop fluorescence turn-off sensor selective l-cys.

Язык: Английский

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Nanozymes: powerful catalytic materials for environmental pollutant detection and degradation

Environmental Science Nano, Год журнала: 2024, Номер 11(3), С. 766 - 796

Опубликована: Янв. 1, 2024

Here we made a critical review on nanozyme-involved detection and degradation of environmental pollutants, the research progress achieved in last five years was emphatically concluded.

Язык: Английский

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Application of Nanozymes in Environmental Monitoring, Management, and Protection

Biosensors, Год журнала: 2023, Номер 13(3), С. 314 - 314

Опубликована: Фев. 24, 2023

Nanozymes are nanomaterials with enzyme-like activity, possessing the unique properties of and natural catalytic functions. catalytically active, stable, tunable, recyclable, versatile. Therefore, increasing attention has been paid in fields environmental science life sciences. In this review, we focused on most recent applications nanozymes for monitoring, management, protection. We firstly introduce tuning activity according to some crucial factors such as size shape, composition doping, surface coating. Then, application introduced detail. can not only be used detect inorganic ions, molecules, organics, foodborne pathogenic bacteria but also involved degradation phenolic compounds, dyes, antibiotics. The capability was reported assisting air purification, constructing biofuel cells, marine antibacterial fouling removal. Finally, current challenges future trends toward proposed discussed.

Язык: Английский

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Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 6, 2024

Abstract The quest for effective and reliable methods of delivering medications, with the aim improving delivery therapeutic agent to intended location, has presented a demanding yet captivating field in biomedical research. concept smart drug systems is an evolving approach, serving as model directing drugs specific targets or sites. These have been developed specifically target regulate administration substances diverse array chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel rheumatoid arthritis, different cancers. Nevertheless, numerous comprehensive clinical trials are still required ascertain both immediate enduring impacts such nanosystems on human subjects. This review delves into benefits vehicles, aiming enhance comprehension their applicability addressing present medical requirements. Additionally, it touches upon current applications these stimuli‐reactive biomedicine outlines future development prospects.

Язык: Английский

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Metal–organic framework-engineered enzyme/nanozyme composites: Preparation, functionality, and sensing mechanisms

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153884 - 153884

Опубликована: Июль 9, 2024

Язык: Английский

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Self-Assembled Integrated Nanozyme Cascade Biosensor with Dual Catalytic Activity for Portable Urease Analysis

Analytical Chemistry, Год журнала: 2024, Номер 96(3), С. 1284 - 1292

Опубликована: Янв. 9, 2024

In this work, a novel nanozyme (Cu@Zr) with all-in-one dual enzyme and fluorescence properties is designed by simple self-assembly. A cascade sensor disodium phenyl phosphate (PPDS) as substrate was first established exploiting the enzymatic activities of phosphatase laccase. Specifically, cleaves P–O bond PPDS to produce colorless phenol, which then oxidized laccase complexed chromogenic agent 4-aminoantipyrine (4-AP) red quinoneimine (QI). Strikingly, NH3 produced urease hydrolysis urea can interact Cu@Zr, accelerating electron transfer rate ultimately leading significantly improved performance reaction. Moreover, at 440 nm Cu@Zr further quenched inner filter effect (IFE) QI. Thus, colorimetric dual-mode strategy for sensitive analysis LODs 3.56 1.83 U/L proposed sensor. Notably, portable swab loaded also prepared in situ detection aid smartphone RGB readout. It provides potentially viable analytical avenue environmental biological analysis.

Язык: Английский

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