ACS Materials Letters,
Год журнала:
2024,
Номер
6(4), С. 1112 - 1119
Опубликована: Фев. 26, 2024
Metal
ion-carbon
based
nanomaterials
served
as
nanozymes
to
mimic
the
biocatalytic
performance
of
natural
enzymes.
However,
there
are
still
challenges
in
constructing
carbon
dots
(CDs)–metal
with
same
coordination
structure
on
chemistry
and
revealing
effect
metal
ion
species
enzyme-mimicking
catalyzed
activities.
Herein,
EDTA-functionalized
dots–metal
(CDsEDTA-Me)
different
ions
(Fe3+,
Cu2+,
Co2+)
structures
synthesized
chemistry.
Species
CDsEDTA-Me
determines
CDsEDTA-Fe,
CDsEDTA-Cu,
CDsEDTA-Co
display
significant
peroxidase
(POD)-mimicking,
superoxide
dismutase
(SOD)-mimicking
activities,
hydroxyl
radical
(•OH)
scavenging
ability,
respectively.
Compared
horseradish
peroxidase,
affinity
CDsEDTA-Fe
H2O2
is
improved
by
47
times.
The
Vm
value
TMB
substrate
1.19
×
10–7
M
s–1.
POD-mimicking
activity
increases
linearly
increase
stability
constants
CDsEDTA-Me,
which
indicates
that
can
be
predicted
CDsEDTA-Me.
provides
a
strategy
for
construction
CDs-metal
rational
improvement
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Фев. 11, 2023
Nanozymes,
a
class
of
nanomaterials
mimicking
the
function
enzymes,
have
aroused
much
attention
as
candidate
in
diverse
fields
with
arbitrarily
tunable
features
owing
to
diversity
crystalline
nanostructures,
composition,
and
surface
configurations.
However,
uncertainty
their
active
sites
lower
intrinsic
deficiencies
nanomaterial-initiated
catalysis
compared
natural
enzymes
promote
pursuing
alternatives
by
imitating
biological
centers.
Single-atom
nanozymes
(SAzymes)
maximize
atom
utilization
well-defined
structure,
providing
an
important
bridge
investigate
mechanism
relationship
between
structure
catalytic
activity.
They
risen
new
burgeoning
alternative
enzyme
from
vitro
bioanalytical
tool
vivo
therapy
flexible
atomic
engineering
structure.
Here,
focus
is
mainly
on
three
parts.
First,
detailed
overview
single-atom
catalyst
synthesis
strategies
including
bottom-up
top-down
approaches
given.
Then,
according
structural
feature
nanocatalysts,
influence
factors
such
central
metal
atom,
coordination
number,
heteroatom
doping,
metal-support
interaction
are
discussed
representative
applications
(including
antibacterial/antiviral
performance,
cancer
therapy,
biosensing)
highlighted.
In
end,
future
perspective
challenge
facing
demonstrated.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
As
a
powerful
tool,
nanozyme
catalysts
broaden
the
avenues
to
implement
bio‐inspired
solutions
for
addressing
many
important
concerns,
covering
energy,
healthcare,
environment,
and
more.
Recent
endeavors,
characterized
by
atomic
precision,
have
enabled
extensive
exploration
of
single‐atom
nanozymes
(SAzymes)
with
high
catalytic
activity,
superior
substrate
selectivity,
integrated
multifunctionalities,
thus
becoming
an
emerging
field
that
bridges
nanotechnology
biology.
This
review
provides
brief
outline
progress
summarizes
latest
research
advances
regarding
SAzymes
in
biomedical
therapeutics,
mainly
including
tumor
therapy,
wound
antibacterial
tissue
anti‐inflammatory
focus
on
their
prototypical
synthesis
therapeutic
mechanisms.
Finally,
current
challenges
future
perspectives
engineering
advanced
are
also
discussed
outlooked.
It
is
anticipated
this
area
shall
provide
useful
guidance
therapy.
Abstract
On
accounts
of
the
advantages
inherent
high
stability,
ease
preparation
and
superior
catalytic
activities,
nanozymes
have
attracted
tremendous
potential
in
diverse
biomedical
applications
as
alternatives
to
natural
enzymes.
Optimizing
activity
is
significant
for
widening
boosting
into
practical
level.
As
research
regulation
strategies
boosting,
it
essential
timely
review,
summarize,
analyze
advances
structure–activity
relationships
further
inspiring
ingenious
this
prosperous
area.
Herein,
methods
recent
5
years
are
systematically
summarized,
including
size
morphology,
doping,
vacancy,
surface
modification,
hybridization,
followed
by
a
discussion
latest
consisting
biosensing,
antibacterial,
tumor
therapy.
Finally,
challenges
opportunities
rapidly
developing
field
presented
more
infant
yet
promising
Environmental Science Nano,
Год журнала:
2024,
Номер
11(3), С. 766 - 796
Опубликована: Янв. 1, 2024
Here
we
made
a
critical
review
on
nanozyme-involved
detection
and
degradation
of
environmental
pollutants,
the
research
progress
achieved
in
last
five
years
was
emphatically
concluded.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 7, 2024
Single-atom
nanozymes
(SAzymes)
showcase
not
only
uniformly
dispersed
active
sites
but
also
meticulously
engineered
coordination
structures.
These
intricate
architectures
bestow
upon
them
an
exceptional
catalytic
prowess,
thereby
captivating
numerous
minds
and
heralding
a
new
era
of
possibilities
in
the
biomedical
landscape.
Tuning
microstructure
SAzymes
on
atomic
scale
is
key
factor
designing
targeted
with
desirable
functions.
This
review
first
discusses
summarizes
three
strategies
for
their
impact
reactivity
biocatalysis.
The
effects
choices
carrier,
different
synthesis
methods,
modulation
first/second
shell,
type
number
metal
centers
enzyme-like
activity
are
unraveled.
Next,
attempt
made
to
summarize
biological
applications
tumor
therapy,
biosensing,
antimicrobial,
anti-inflammatory,
other
from
mechanisms.
Finally,
how
designed
regulated
further
realization
diverse
reviewed
prospected.
It
envisaged
that
comprehensive
presented
within
this
exegesis
will
furnish
novel
perspectives
profound
revelations
regarding
SAzymes.
Analytica Chimica Acta,
Год журнала:
2023,
Номер
1284, С. 341874 - 341874
Опубликована: Окт. 9, 2023
Carbon
nanoparticles
(CDs)
have
recently
drawn
a
great
attention
in
(bio)chemical
analysis,
sensing
and
bioimaging
owing
to
their
photostability,
water
stability,
minimal
toxicity,
biocompatibility
ease
of
surface
functionalization.
While
the
vast
majority
CDs
applications
rely
on
exploiting
fluorescent
properties,
doping
such
nanomaterials
with
various
elements
has
received
increasing
as
an
effective
approach
modify
optoelectronic
characteristics,
introducing
novel
improved
optical
features
phosphorescence,
upconversion
luminescence
or
multimodal
imaging
capabilities.
This
review
article
focuses
recent
advances
synthesis
heteroatom-doped
CDs,
exhibiting
distinctive
high
value
for
imaging,
well
functionalization
schemes
developed
guided
analyte
labeling.
Relevant
chemical
sensing,
disease
therapy
are
here
presented.
A
final
section
intends
provide
overview
towards
future
developments
emerging
light-emitting
design
devices
strategies
(bio)analytical
chemistry.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 13, 2024
Abstract
As
nanoscale
materials
with
the
function
of
catalyzing
substrates
through
enzymatic
kinetics,
nanozymes
are
regarded
as
potential
alternatives
to
natural
enzymes.
Compared
protein‐based
enzymes,
exhibit
attractive
characteristics
low
preparation
cost,
robust
activity,
flexible
performance
adjustment,
and
versatile
functionalization.
These
advantages
endow
them
wide
use
from
biochemical
sensing
environmental
remediation
medical
theranostics.
Especially
in
biomedical
diagnosis,
feature
catalytic
signal
amplification
provided
by
makes
emerging
labels
for
detection
biomarkers
diseases,
rapid
developments
observed
recent
years.
To
provide
a
comprehensive
overview
progress
made
this
dynamic
field,
here
an
diagnosis
enabled
is
provided.
This
review
first
summarizes
synthesis
nanozyme
then
discusses
main
strategies
applied
enhance
their
activity
specificity.
Subsequently,
representative
utilization
combined
biological
elements
disease
reviewed,
including
related
metabolic,
cardiovascular,
nervous,
digestive
diseases
well
cancers.
Finally,
some
development
trends
nanozyme‐enabled
highlighted,
corresponding
challenges
also
pointed
out,
aiming
inspire
future
efforts
further
advance
promising
field.
