Ultrasound-Assisted Extraction, Identification, and Quantification of Antioxidants from ‘Jinfeng’ Kiwifruit

Foods, Год журнала: 2022, Номер 11(6), С. 827 - 827

Опубликована: Март 14, 2022

Kiwifruit (Actinidia chinensis) is a nutrient-dense fruit abundant in vitamin C and phenolic compounds, it exhibits strong antioxidant capacity. However, the antioxidants ‘Jinfeng’ kiwifruit have seldom been extracted analyzed, conditions for extraction of by ultrasound-assisted (UAE) investigated. In this study, response surface methodology (RSM) was used to optimize UAE extract from kiwifruit. addition, capacity, contents total phenolics flavonoids, ascorbic acid, profiles were also analyzed. The results showed that optimal included 68% ethanol, liquid/solid ratio at 20 mL/g, time 30 min, temperature 42 °C, ultrasonic power 420 W. Under these conditions, ABTS value 70.38 ± 1.38 μM TE/g DW, which 18.5% higher than obtained conventional solvent extraction. flavonoid 15.50 0.08 mg GAE/g DW 5.10 0.09 CE/g respectively. Moreover, compounds tentatively identified UPLC–MS/MS, content main such as procyanidin B2, neochlorogenic epicatechin, determined HPLC–DAD. This research revealed phytochemicals kiwifruit, can be good dietary source natural with potential health functions.

Язык: Английский

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Antitumor Effects of Cannabinoids in Human Pancreatic Ductal Adenocarcinoma Cell Line (Capan-2)-Derived Xenograft Mouse Model

Frontiers in Veterinary Science, Год журнала: 2022, Номер 9

Опубликована: Июль 22, 2022

Pancreatic cancer is considered a rare type of cancer, but the mortality rate high. Cannabinoids extracted from cannabis plant have been interested as an alternative treatment in patients. Only few studies are available on antitumor effects cannabinoids pancreatic cancer. Therefore, this study aims to evaluate xenografted mouse model.Twenty-five nude mice were subcutaneously transplanted with human ductal adenocarcinoma cell line (Capan-2). All randomly assigned into 5 groups including negative control (gavage sesame oil), positive (5 mg/kg 5-fluorouracil intraperitoneal administration), and that daily received THC:CBD, 1:6 at 1, 5, or 10 body weight for 30 days, respectively. Xenograft tumors internal organs collected histopathological examination immunohistochemistry.The average tumor volume was increased all no significant difference. The apoptotic cells caspase-3 significantly cannabinoid compared group. expression score proliferating nuclear antigen decreased group.Cannabinoids effect Capan-2-derived xenograft model though induce apoptosis inhibit proliferation dose-dependent manner.

Язык: Английский

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Extraction, purification, structural features and biological activities of longan fruit pulp (Longyan) polysaccharides: A review

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Июль 25, 2022

Dimocarpus longan Lour . (also called as longan) is a subtropical and tropical evergreen tree belonging to the Sapindaceae family widely distributed in China, Southeast Asia South Asia. The pulp of fruit time-honored traditional medicinal edible raw material China some Asian countries. With advancement food therapy modern medicine, an expected usher its rapid development functional nutrient. As one main constituents pulp, polysaccharides (LPs) play indispensable role pulp-based utilization. This review aims outline extraction purification methods, structural characteristics biological activities (such immunoregulatory, anti-tumor, prebiotic, anti-oxidant, anti-inflammatory inhibition AChE activity) LPs. Besides, structure-activity relationship, application prospect patent LPs were analyzed summarized. Through systematic summary, this attempts provide theoretical basis for further research LPs, promote industrial class polysaccharides.

Язык: Английский

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Recent Research on Cannabis sativa L.: Phytochemistry, New Matrices, Cultivation Techniques, and Recent Updates on Its Brain-Related Effects (2018–2023)

Molecules, Год журнала: 2023, Номер 28(8), С. 3387 - 3387

Опубликована: Апрель 12, 2023

Cannabis sativa L. is a plant that humankind has been using for millennia. The basis of its widespread utilization adaptability to so many different climatic conditions, with easy cultivability in numerous diverse environments. Because variegate phytochemistry, C. used sectors, although the discovery presence several psychotropic substances (e.g., Δ9-tetrahydrocannabinol, THC) caused drastic reduction cultivation and use together official ban from pharmacopeias. Fortunately, varieties low content THC as well biotechnological development new clones rich phytochemical components endorsed peculiar important bioactivities demanded reassessment these species, study which are currently experiencing developments. In this review we focus our attention on matrices, suitable agronomic techniques, biological activities developed five last years.

Язык: Английский

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Uncovering the metabolite complexity and variability of cultivated hemp (Cannabis sativa L.): A first phytochemical diversity mapping in Greece

Phytochemistry, Год журнала: 2024, Номер 222, С. 114076 - 114076

Опубликована: Апрель 1, 2024

Язык: Английский

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