Strategies to Improve the Output Performance of Triboelectric Nanogenerators

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Фев. 8, 2024

Abstract Triboelectric nanogenerators (TENGs) can collect and convert random mechanical energy into electric energy, with remarkable advantages including broadly available materials, straightforward preparation, multiple applications. Over the years, researchers have made substantial advancements in theoretical practical aspects of TENG. Nevertheless, pivotal challenge realizing full applications TENG lies ensuring that generated output meets specific application requirements. Consequently, research is dedicated to exploring methods mechanisms for enhancing performance devices. This review aims comprehensively examine influencing factors corresponding improvement strategies based on contact electrification mechanism operational principles underlie technology. primarily delves five key areas improvement: materials selection, surface modification, component adjustments, structural optimization, electrode enhancements. These are crucial tailoring devices meet desired metrics various

Язык: Английский

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An affordable label-free ultrasensitive immunosensor based on gold nanoparticles deposited on glassy carbon electrode for the transferrin receptor detection

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 133083 - 133083

Опубликована: Июнь 12, 2024

Язык: Английский

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A Versatile Electrochemical Biosensor for the Detection of Circulating MicroRNA toward Non‐Small Cell Lung Cancer Diagnosis

Small, Год журнала: 2022, Номер 18(22)

Опубликована: Март 25, 2022

Abstract Circulating microRNAs (miRNAs) can be used as noninvasive biomarkers and are also found circulating in body fluids such blood. Dysregulated miRNA expression is associated with many diseases, including non‐small cell lung cancer (NSCLC), the assay helpful diagnosis, prognosis, monitoring. In this work, a versatile electrochemical biosensing system developed for detection by DNAzyme‐cleavage cycling amplification hybridization chain reaction (HCR) amplification. With cleavage Mn 2+ targeted DNAzyme, DNA‐walker move along predesigned DNA tracks contribute to transduction enhancement of signals. For process, formation multiple G‐quadruplex‐incorporated long double‐stranded (dsDNA/G‐quadruplex) structures triggered through HCR The introduction G‐quadruplex allows sensitive measurement down 5.68 fM good specificity. Furthermore, profiling NSCLC cohort, designed strategy shows high efficiency (area under curve (AUC) 0.879 using receiver operating characteristic (ROC) analysis) sensitivity 80.0% early diagnosis (stage I). discrimination benign disease, displays an AUC 0.907, superior six clinically‐acceptable protein tumor markers. Therefore, platform holds promise clinical application toward prognosis.

Язык: Английский

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Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Small, Год журнала: 2023, Номер 19(20)

Опубликована: Фев. 17, 2023

Abstract Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their rich biological fingerprints and high level of stability. However, the accurate detection exosomes with specific surface receptors is limited clinical application. Herein, an exosome enrichment platform on a 3D porous sponge microfluidic chip constructed capture efficiency this ≈90%. Also, deep mass spectrometry analysis followed by multi‐level expression screenings revealed CRC‐specific membrane protein (SORL1). A method SORL1 quantum dot labeling further designed ensemble classification system established extracting features from 64‐patched fluorescence images. Importantly, area under curve (AUC) using 0.99, which significantly higher ( p < 0.001) than that conventional biomarker (carcinoembryonic antigen (CEA), AUC 0.71). The above showed similar diagnostic performance, dealing early‐stage CRC, young CEA‐negative CRC patients.

Язык: Английский

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Dual-mode biosensor platform based on synergistic effects of dual-functional hybrid nanomaterials

Talanta, Год журнала: 2023, Номер 260, С. 124584 - 124584

Опубликована: Апрель 28, 2023

Язык: Английский

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Host–Guest Self‐Assembled Interfacial Nanoarrays for Precise Metabolic Profiling

Small, Год журнала: 2023, Номер 19(51)

Опубликована: Янв. 26, 2023

Abstract Accurate and rapid metabolic profiling of cerebrospinal fluid (CSF) is urgently needed but remains challenging for clinical diagnosis central nervous system diseases biomarker discovery. Matrix‐assisted laser desorption ionization mass spectrometry (MALDI‐MS) holds promise analysis. Its low signal reproducibility, however, severely restricts acquisition quantitative MS data in practice. Herein, a multifunctional self‐assembled AuNPs array (MSANA)‐based LDI‐MS platform direct amino acids analysis patient CSF samples developed. MSANA featuring highly ordered closely packed two‐dimensional nanostructure permits capture aromatic by with high selectivity micromolar sensitivity. Meanwhile, the MSANA‐based exhibits excellent reproducibility (RSD < 10%), largely outperforming matrix spotting approach widely used now 44%). The successfully (1 µL) within minutes discrimination medulloblastoma patients from non‐tumor controls. Taken together, shows potential values toward large‐scale diagnostics pathogenic mechanism study.

Язык: Английский

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Moving toward smart biomedical sensing

Biosensors and Bioelectronics, Год журнала: 2022, Номер 223, С. 115009 - 115009

Опубликована: Дек. 15, 2022

Язык: Английский

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Integrating Paper‐Based Microfluidics and Lateral Flow Strip into Nucleic Acid Amplification Device toward Rapid, Low‐Cost, and Visual Diagnosis of Multiple Mycobacteria

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Март 11, 2024

Abstract Efficient diagnosis of mycobacterial infections can effectively manage and prevent the transmission infectious diseases. Unfortunately, existing diagnostic strategies are challenged by long assay times, high costs, highly specialized expertise to distinguish between pulmonary tuberculosis (PTB) nontuberculous diseases (NTM‐PDs). Herein, in this study, an optimized 3D paper‐based analytical device (µPAD) is incorporated with a closed lateral flow (LF) strip into loop‐mediated isothermal amplification (LAMP) (3D‐µPAD‐LF‐LAMP) for rapid, low‐cost, visual detection pathogenic mycobacteria. The platform's microfluidic feature enhanced nucleic acid amplification, thereby reducing costs time as compared boiling, easyMAG, QIAGEN techniques. Moreover, LF unit specifically designed minimize aerosol contamination user‐friendly readout. 3D‐µPAD‐LF‐LAMP assessed using standard strains, demonstrating limit (LOD) down 10 fg reaction −1 . In cohort 815 patients, displays significantly better sensitivity, specificity, negative predictive value (NPV), positive (PPV), accuracy than conventional bacterial culture Xpert Collectively, demonstrates accessibility, efficiency, practicality multiple mycobacteria, which be applied across diverse clinical settings, ultimately improving public health outcomes.

Язык: Английский

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Advances and challenges of signal readout systems in CRISPR-based biosensors for point-of-care testing of nucleic acid

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117856 - 117856

Опубликована: Июль 9, 2024

Язык: Английский

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AuNPs/CNC Nanocomposite with A “Dual Dispersion” Effect for LDI‐TOF MS Analysis of Intact Proteins in NSCLC Serum Exosomes

Advanced Science, Год журнала: 2024, Номер 11(12)

Опубликована: Янв. 15, 2024

Abstract Detecting exosomal markers using laser desorption/ionization time‐of‐flight mass spectrometry (LDI‐TOF MS) is a novel approach for examining liquid biopsies of non‐small cell lung cancer (NSCLC) samples. However, LDI‐TOF MS limited by low sensitivity and poor reproducibility when analyzing intact proteins directly. In this report, gold nanoparticles/cellulose nanocrystals (AuNPs/CNC) introduced as the matrix direct analysis in NSCLC serum exosomes. AuNPs/CNC with “dual dispersion” effects dispersed stabilized AuNPs improved ion inhibition caused protein aggregation. These features increased signal‐to‐noise ratio [M+H] + peaks two orders magnitude lowered detection limit to 0.01 mg mL –1 . The coefficient variation or without measured 10.2% 32.5%, respectively. excellent yielded linear relationship ( y = 15.41 x – 7.983, R 2 0.989) over concentration range 20 Finally, AuNPs/CNC‐assisted provides clinically relevant fingerprint information serum, characteristic S100 calcium‐binding A10, Urokinase plasminogen activator surface receptor, Plasma protease C1 inhibitor, Tyrosine‐protein kinase Fgr Mannose‐binding lectin associated serine represented predictive biomarkers risk.

Язык: Английский

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