Viral
nanoparticles
(VNPs)
have
emerged
as
crucial
tools
in
the
field
of
biomedicine.
Leveraging
their
biological
and
physicochemical
properties,
VNPs
exhibit
significant
advantages
prevention,
diagnosis,
treatment
human
diseases.
Through
techniques
such
chemical
bioconjugation,
infusion,
genetic
engineering,
encapsulation,
these
been
endowed
with
multifunctional
capabilities,
including
display
functional
peptides
or
proteins,
encapsulation
therapeutic
drugs
inorganic
particles,
integration
imaging
agents,
conjugation
bioactive
molecules.
This
review
provides
an
in-depth
analysis
biomedicine,
elucidating
diverse
types,
distinctive
features,
production
methods,
complex
design
principles
behind
VNPs.
It
highlights
recent
innovative
research
various
applications,
covering
roles
imaging,
drug
delivery,
therapeutics,
gene
vaccines,
immunotherapy,
tissue
regeneration.
Additionally,
assessment
safety
biocompatibility
discusses
challenges
future
opportunities
field,
underscoring
vast
potential
evolving
nature
VNP
research.
ACS Nano,
Год журнала:
2024,
Номер
18(26), С. 16752 - 16765
Опубликована: Июнь 20, 2024
Although
lateral
flow
immunochromatographic
assay
(LFIA)
is
an
effective
point-of-care
testing
technology,
it
still
cannot
achieve
broad-spectrum
and
ultrasensitive
detection
of
viruses.
Herein,
we
propose
a
multiplex
LFIA
platform
using
two-dimensional
graphene
oxide
(GO)-based
magnetic
fluorescent
nanofilm
(GF@DQD)
as
multifunctional
probe
4-aminophenylboronic
acid
(APBA)
recognition
molecule
for
viral
glycoprotein
detection.
GF@DQD-APBA
with
enhanced
magnetic/fluorescence
properties
universal
capture
ability
multiple
viruses
was
easily
prepared
through
the
electrostatic
adsorption
one
layer
density-controlled
Fe3O4
nanoparticles
(NPs)
thousands
small
CdSe/ZnS-MPA
quantum
dots
(QDs)
on
monolayer
GO
sheet
followed
by
chemical
coupling
APBA
QD
surface.
The
enabled
specific
determination
different
target
test
strip
arbitrary
combination
antibody-modified
strip,
thus
greatly
improving
efficiency
reducing
cost
difficulty
proposed
technique
can
simultaneously
sensitively
diagnose
three
newly
emerged
within
20
min
limits
down
to
pg/mL
level.
excellent
practicability
GF@DQD-APBA-LFIA
also
demonstrated
in
34
clinical
specimens
positive
SARS-CoV-2,
revealing
its
potential
epidemic
control
on-site
Chemical Reviews,
Год журнала:
2024,
Номер
124(20), С. 11242 - 11347
Опубликована: Окт. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
Food Safety and Health,
Год журнала:
2024,
Номер
2(1), С. 72 - 95
Опубликована: Янв. 1, 2024
Abstract
Food
contaminants
have
consistently
posed
a
serious
threat
to
human
health
and
caused
various
food
safety
problems.
The
most
common
techniques
currently
used
for
the
detection
of
contaminants,
include
instrumental
immunoassay
methods;
however,
these
traditional
methods
shown
some
limitations
when
applied
analysis
contaminants.
Therefore,
in
recent
years,
more
researchers
been
devoted
development
rapid,
reliable,
sensitive,
suitable
matrices.
In
this
review,
we
first
classify
analytical
proposed
years
into
colorimetric
methods,
fluorescence
photoelectrochemical
electrochemical
nucleic
acid
amplification
other
illustrate
their
principles.
addition,
paper
highlights
strategies
research
advances
each
method
through
typical
application
examples.
Finally,
future
perspectives
are
presented.
We
hope
that
review
will
provide
with
valuable
insights
guide
sensitive
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
