Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162115 - 162115
Опубликована: Март 1, 2025
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150612 - 150612
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
63
Coordination Chemistry Reviews, Год журнала: 2024, Номер 520, С. 216166 - 216166
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
34
Biosensors and Bioelectronics, Год журнала: 2024, Номер 255, С. 116271 - 116271
Опубликована: Апрель 3, 2024
Язык: Английский
Процитировано
33
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 242, С. 114093 - 114093
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
27
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 13, 2024
Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.
Язык: Английский
Процитировано
23
Small Structures, Год журнала: 2024, Номер 5(6)
Опубликована: Март 25, 2024
Traditional antibacterial agents are often observed to be ineffective because bacteria evolved strains with greater antibiotic resistance. Here, vigorous chitosan‐stabilized PtAu nanoparticles (CSPA) multienzyme‐like activity successfully fabricated, which serve an effective artificial nanozyme enhance for mixed bacterial infection wound treatment. Ultrasmall size CSPA exhibits excellent hydrophilicity and biocompatibility, possesses strong oxidase‐ peroxidase‐like generating a substantial amount of ROS (, 1 O 2 , ·OH) cause oxidative damage bacteria, also demonstrates nicotinamide adenine dinucleotide dehydrogenase‐like disrupting the respiratory chains, subsequently impedes adenosine triphosphate production. favorable broad‐spectrum at very low concentrations, prevents resistance, completely inhibits biofilm formation. Antibacterial Mechanism by transcriptomics is further revealed that can induce stress, hinder energy metabolism, disrupt synthesis function cell walls membranes. In vivo, population site promotes healing in rats. This study introduces novel approach, providing important insight into mechanism nanozymes promoting advancement nanocatalytic materials biomedical applications.
Язык: Английский
Процитировано
20
ACS Nano, Год журнала: 2024, Номер 18(20), С. 12639 - 12671
Опубликована: Май 8, 2024
Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.
Язык: Английский
Процитировано
19
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Abstract Nanozymes with atomically dispersed metal sites (ADzymes), especially single‐atom nanozymes, have attracted widespread attention in recent years due to their unique advantages mimicking the active of natural enzymes. These nanozymes not only maximize exposure catalytic but also possess superior activity performance, achieving challenging reactions. position ADzymes as highly promising candidates field sensing and biosensing. This review summarizes classification properties ADzymes, systematically highlighting some typical regulation strategies involving central metal, coordination environment, etc., achieve catalytical activity, specificity, multifunctionality. Then, we present advances different fields, including colorimetry, fluorescence, electrochemistry, chemiluminescence, photoelectrochemistry, electrochemiluminescence. Taking advantage resultant show great potential goal sensitivity, selectivity accuracy for detection various targets. Specifically, underlying mechanisms terms signal amplification were discussed detail. Finally, current challenges perspectives on development advanced are discussed.
Язык: Английский
Процитировано
3
Chemosphere, Год журнала: 2023, Номер 346, С. 140557 - 140557
Опубликована: Окт. 28, 2023
Язык: Английский
Процитировано
25
Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134323 - 134323
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
18