Environmental Chemistry Letters, Год журнала: 2024, Номер 22(6), С. 2753 - 2775
Опубликована: Окт. 4, 2024
Язык: Английский
Analytica Chimica Acta, Год журнала: 2024, Номер 1323, С. 342889 - 342889
Опубликована: Июнь 20, 2024
Separation analytical methods, including liquid chromatography (LC) and capillary electrophoresis (CE), in combination with an appropriate detection technique, are dominant powerful approaches preferred the analysis of pharmaceutical biomedical samples. Recent trends methods focused on activities that push them to field greenness sustainability. New based implementation greener solvents, non-hazardous chemicals, reagents have grown exponentially. Similarly, recent pushed strategies miniaturization, reduction wastes, avoiding derivatization procedures, or energy consumption. However, real method can be evaluated only according objective sufficient metric offering complex results taking into account all twelve rules green chemistry (SIGNIFICANCE mnemonic system). This review provides extensive overview papers published area development LC CE over last 5 years (2019-2023). The main focus is situated metrics used for evaluation applied determination bioactive agents. It critically evaluates compares demands applicability quality control clinical environment requirements (GAC). Greenness practicality summarized re-evaluated newly use tools, i.e., Analytical GREEnness (AGREE), Green Procedure Index (GAPI), Blue Applicability Grade (BAGI), Sample Preparation Metric Sustainability (SPMS). Moreover, general conclusions future perspectives greening procedures systems presented. paper should provide comprehensive information chemists, biochemists, it also represent a valuable source clinicians, laboratories interested greenness, practicality,
Язык: Английский
Процитировано
11
Journal of Separation Science, Год журнала: 2024, Номер 47(19)
Опубликована: Окт. 1, 2024
The increasing awareness of environmental issues and the transition to green analytical chemistry (GAC) have gained popularity among academia industry in recent years. One principles GAC is reduction replacement toxic solvents with more sustainable environmentally friendly ones. This review gives an overview advances applying as alternative traditional organic for peptide protein purification analysis by liquid chromatography (LC) capillary electrophoresis (CE) methods. feasibility using greener LC CE methods demonstrated through several application examples; however, there still plenty room new developments fully realize their potential address existing challenges. Thanks tunable properties designer solvents, such ionic liquids deep eutectic almost infinite possible mixtures components production, it that some could potentially surpass harmful future. Therefore, future research should focus mainly on developing solvent combinations enhancing instruments be able effectively work solvents.
Язык: Английский
Процитировано
5
Green Analytical Chemistry, Год журнала: 2024, Номер 8, С. 100094 - 100094
Опубликована: Янв. 11, 2024
A novel chiral monolithic nano-column was developed for the enantioseparation of drugs by nano-liquid chromatography (nano-LC). The capillary with 50 µm i.d. first prepared an in-situ polymerization using butyl methacrylate (BuMA), ethylene dimethacrylate (EDMA) and NFMoc-Lysine modified GO nanoparticles. final stationary phase characterized FT-IR spectra synthesized structures, scanning electron microscopy (SEM) chromatographic analyses. After characterization, column investigated separation pharmaceutical racemates, including anti-inflammatory (e.g., ketoprofen, ibuprofen, naproxen, etodolac flurbiprofen) β-blockers (e.g. propranolol, metoprolol atenolol). It demonstrated that nanoparticles incorporated monolith could be successfully while this allowed sensitive drugs. mostly achieved via formation π-π interactions as well hydrophilic between enantiomers
Язык: Английский
Процитировано
3
Green Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 100226 - 100226
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Egyptian Journal of Forensic Sciences, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 26, 2025
Abstract Background Body fluids (BFs) are highly important in forensically relevant scenarios. Historically, conventional techniques have been used for their identification and detection purposes. However, there is no technology available that can detect a mixture of body one go. Main There need an advanced confirmatory technique reliably all types even trace forms, whether pure form or form. The discussed spectroscopic include raman spectroscopy, fourier transform infrared (FTIR), mass spectroscopy (MS), nuclear magnetic resonance (NMR). Conclusions These reviewed proven to be advanced, confirmatory, mostly non-destructive, sensitive, reliable, reproducible fluid when combined with statistical analysis reference databases. 1 H NMR emerging versatile wide-ranging forensic applications. progressive research related these revolutionize the field forensics.
Язык: Английский
Процитировано
0
Green Analytical Chemistry, Год журнала: 2024, Номер 10, С. 100131 - 100131
Опубликована: Июль 27, 2024
Nano-scale separation techniques (NSTs) offer significant advantages in relation to drug analysis a wide range of samples. NSTs, including low flow rate LC systems or capillary chip based electrophoresis/electrochromatography systems, have become the primary tool for advanced analysis, and indispensable technology sensitive selective analysis. In recent decades, advances been achieved using NSTs this review, sample preparation strategies, new applications contribution toward forensic science were reported. addition, some selected with without mass spectrometry (e.g., resolution/high resolution -MS) are summarized.
Язык: Английский
Процитировано
1
Environmental Chemistry Letters, Год журнала: 2024, Номер 22(6), С. 2753 - 2775
Опубликована: Окт. 4, 2024
Язык: Английский
Процитировано
1