International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138549 - 138549
Опубликована: Дек. 9, 2024
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(27)
Опубликована: Июнь 2, 2024
Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.
Язык: Английский
Процитировано
31
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101502 - 101502
Опубликована: Янв. 19, 2025
DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These facilitate the formation of spatial structures through bulk hydrogel fabricating, microsphere formatting, 3D printing. Furthermore, microenvironment can be finely tuned by leveraging degradation products, nanostructure, targeting, delivery capabilities inherent materials. In this review, we underscore advantages hydrogels, detailing composition, gelation techniques, structure optimization. We then delineate three critical elements in promotion using hydrogels: (i) osteogenesis driven phosphate ions, plasmids, oligodeoxynucleotides (ODNs) that enhance mineralization promote gene protein expression; (ii) vascularization facilitated tetrahedral DNA nanostructures (TDNs) aptamers, which boosts expression targeted release; (iii) immunomodulation achieved loaded factors, TDNs, bound ions stimulate macrophage polarization exhibit antibacterial properties. With these properties, used construct organoids, providing an innovative tool disease modeling therapeutic applications tissue engineering. Finally, discuss current challenges future prospects, emphasizing potential impacts regenerative medicine.
Язык: Английский
Процитировано
5
Advanced Biology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
Abstract Deoxyribonucleic acid (DNA) nanotechnology has brought an unparalleled set of possibilities for self‐assembled structures emerging as independent branch synthetic biology. The field science uses the molecular properties DNA to build nanoparticles and nanodevices that have potential bring breakthroughs in medical science. On one hand, their biocompatibility, precision, ease, programmability make them ideal choice drug delivery healthcare. other, lack proper biodistribution profiles, stability inside system, enzymatic cleavage, immune recognition, translational barriers are some hurdles it faces. Many recent technological advancements progress tackle these challenges, while already been used. These tools technologies need be understood studied successful transition intelligent nanostructures (DNs) healthcare applications. This review thus, highlights challenges being faced by DNs Additionally, provides overview trends using devices disease detection remission finally talks about future scope opportunities effective from bench bedside.
Язык: Английский
Процитировано
2
Results in Engineering, Год журнала: 2024, Номер unknown, С. 103428 - 103428
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
8
Analytical Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
Current nucleic acid-responsive DNA hydrogels face significant challenges, such as the requirement for high target concentrations, frequent redesigns, and increased costs, which limit their practical applications in biosensing. To address these issues, we developed a novel biosensing platform integrating CRISPR/Cas12a system into an RCA-based hydrogel. The hydrogel used could preencapsulate diverse signal molecules comprising GelRed, methylene blue, gold nanoparticles, were released upon Cas12a-mediated cleavage. This design enabled customizable output, including fluorescence, electrochemistry, colorimetry, thereby ensuring platform's adaptability to various detection scenarios. Our was highly specific methicillin-resistant
Язык: Английский
Процитировано
6
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 29, 2024
Deoxyribonucleotide (DNA) is uniquely programmable and biocompatible, exhibits unique appeal as a biomaterial it can be precisely designed programmed to construct arbitrary shapes. DNA hydrogels are polymer networks comprising cross-linked strands. As present programmability, biocompatibility, stimulus responsiveness, they extensively explored in the field of biomedicine. In this study, we provide an overview recent advancements hydrogel technology. We outline different design philosophies methods preparation, discuss its special physicochemical characteristics, highlight various uses biomedical domains, such drug delivery, biosensing, tissue engineering, cell culture. Finally, current difficulties facing their potential future development.
Язык: Английский
Процитировано
5
Biosensors and Bioelectronics, Год журнала: 2024, Номер 267, С. 116803 - 116803
Опубликована: Сен. 19, 2024
Язык: Английский
Процитировано
3
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101486 - 101486
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
0
Food and Bioprocess Technology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
0