Integrating machine learning and biosensors in microfluidic devices: A review

Biosensors and Bioelectronics, Год журнала: 2024, Номер 263, С. 116632 - 116632

Опубликована: Авг. 3, 2024

Microfluidic devices are increasingly widespread in the literature, being applied to numerous exciting applications, from chemical research Point-of-Care devices, passing through drug development and clinical scenarios. Setting up these microenvironments, however, introduces necessity of locally controlling variables involved phenomena under investigation. For this reason, literature has deeply explored possibility introducing sensing elements investigate physical quantities biochemical concentration inside microfluidic devices. Biosensors, particularly, well known for their high accuracy, selectivity, responsiveness. However, signals could be challenging interpret must carefully analysed carry out correct information. In addition, proper data analysis been demonstrated even increase biosensors' mentioned qualities. To regard, machine learning algorithms undoubtedly among most suitable approaches undertake job, automatically highlighting biosensor signals' characteristics at best. Interestingly, it was also benefit themselves, a new paradigm that is starting name "intelligent microfluidics", ideally closing benefic interaction disciplines. This review aims demonstrate advantages triad microfluidics-biosensors-machine learning, which still little used but great perspective. After briefly describing single entities, different sections will benefits dual interactions, applications where reviewed employed.

Язык: Английский

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Sensitive and selective detection of heavy metal ions and organic pollutants with graphene-integrated sensing platforms

Nanoscale, Год журнала: 2024, Номер 16(30), С. 14195 - 14212

Опубликована: Янв. 1, 2024

Graphene based sensing platforms offer effective and selective detection of heavy metal ions organic pollutants in the environment.

Язык: Английский

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Engineering Group VI Transition Metal Dichalcogenides for Designing Various Sensors

Advanced Materials Technologies, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Abstract Recent advancements in sensor technology are driven by progress materials science and increasing demands from applications such as health diagnostics. Particularly, with the push nanotechnology biocompatible materials, has made significant progress. Sensor have been greatly enhanced unique properties of transition metal dichalcogenides (TMDs). These high‐performance sensors not only improve accuracy measurements but also provide robust support for real‐time data analysis. To further demonstrate latest technology, this paper specifically introduces recent researches based on WS 2 , MoS their composites. Herein, structures TMDs systematically described, highlighting strong potential advancing development. Then, Group VI various domains, including humidity sensors, temperature gas biosensors, image strain is discussed. Through detailed analysis function performance these areas, aims to emphasize advantages materials. The summarized, a glimpse into what future holds using offered.

Язык: Английский

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Theranostic applications of graphene-based materials in lung cancer: A review

FlatChem, Год журнала: 2025, Номер unknown, С. 100871 - 100871

Опубликована: Апрель 1, 2025

Язык: Английский

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Field effect transistor biosensors for healthcare monitoring

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Abstract The burgeoning demand for healthcare monitoring has brought field effect transistor (FET) biosensors into the spotlight as a highly efficient detection technology. FET offer inherent advantages including high sensitivity, rapid response times, operational simplicity, integrability, and label‐free detection. These characteristics render them particularly well‐suited detecting diverse array of physiological parameters biomarkers, thereby furnishing real‐time data crucial personalized medicine disease prevention. This review aims to elucidate recent advancements in within realm management encompassing several facets. Initially, this systematically analyzes device architecture, sensing mechanisms, performance evaluation methods gain an in‐depth understanding their principles features. Subsequently, it focuses on application health‐related biomarkers nucleic acids, proteins, exosomes, viruses, etc. Lastly, presents engineered medical sensor prototypes predicated biosensors, such point‐of‐care testing devices, wearable sensors, implantable underscoring practical utility potential health management. In addition, addresses critical issues prospects using monitoring, aiming provide some references insights research innovation field.

Язык: Английский

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Advances in 2D materials for wearable biomonitoring

Materials Science and Engineering R Reports, Год журнала: 2025, Номер 164, С. 100971 - 100971

Опубликована: Март 12, 2025

Язык: Английский

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Molybdenum Disulfide Nanocomposites for Cancer Diagnosis and Therapeutics: Biosensors, Bioimaging, and Phototherapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

Abstract Molybdenum disulfide (MoS₂) nanomaterials have attracted significant interest in cancer diagnosis and therapy due to their unique physicochemical properties. Due its extensive surface area adaptable structure, MoS₂ may engage with pharmaceuticals biomolecules via covalent non‐covalent interactions. This versatility enhances the sensitivity of identifying specific biomarkers, colloidal stability, tumor‐targeting capabilities. In near‐infrared (NIR) spectrum, exhibits strong optical absorption efficient photothermal conversion, making it suitable for NIR‐driven phototherapy regulated medication release. Functionalized nanocomposites react differently tumor microenvironment, which improves treatment effectiveness by increasing drug accumulation at sites decreasing off‐target effects on healthy tissues. Recent developments MoS₂‐based detection are reviewed this study, particular attention paid uses therapy, photodynamic biosensing, bioimaging. Additionally, looks difficulties potential applications cancer.

Язык: Английский

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Key Aspects of Biosensing for Instant Screening Tests

Biosensors and Bioelectronics X, Год журнала: 2024, Номер 20, С. 100529 - 100529

Опубликована: Авг. 13, 2024

Язык: Английский

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Wrinkled PDMS-Based Graphene Field Effect Transistor Biosensor

ACS Applied Electronic Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Real-time cell proliferation assays, incorporating fluorescent dyes into cells and bulky optical imaging systems, are the gold standard for cellular analysis at single-cell level. As components of a simplified miniaturized system, conventional field-effect transistor (FET)-based platform allows label-free detection biomolecules by measuring their inherent charge carriers. In this study, we developed winkled graphene-based FET (G-FET) to evaluate process with directional characteristics myoblast alignment, compared approach. Various uniaxially wrinkled structures highly uniform regular patterns were obtained over millimeter scale channel tuning fabrication parameters on G-FET through facile fabrication. result, it showed that enhanced electrical signals during growth from in vitro culture flat device, giving guidance orientations sensing capability proliferation. The improvement sensitivity was verified various concentrations ion. Through detection, our will support bringing complex lab-based diagnostic assays small-footprint devices efficient directionality.

Язык: Английский

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Amplification‐free sub-femtomolar monitoring of SARS-CoV-2-RNA in serum samples using cDNA-modified MoS2 field-effect transistor

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 111955 - 111955

Опубликована: Окт. 1, 2024

Язык: Английский

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