Microchimica Acta, Год журнала: 2024, Номер 191(11)
Опубликована: Окт. 7, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(38)
Опубликована: Авг. 9, 2024
Dual-mode readout platforms with colorimetric and electrochemiluminescence (ECL) signal enhancement are proposed for the ultrasensitive flexible detection of monkeypox virus (MPXV) in different scenes. A new nanotag, Ru@U6-Ru/Pt NPs is constructed dual-mode by integrating double-layered ECL luminophores nanozyme using Zr-MOF (UiO-66-NH
Язык: Английский
Процитировано
38
iLABMED, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
ABSTRACT The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid accurate detection complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, treatment management. Advances novel biomaterials have led to device integration into wearable implantable systems point‐of‐care testing. Here, we review recent advances clinical detecting nucleic acids, proteins, metabolites, pathogens, cellular components. We outline the prospects devices based on analysis biofluids such as sweat discuss remaining challenges facing application biosensors.
Язык: Английский
Процитировано
0
Biosensors, Год журнала: 2025, Номер 15(4), С. 222 - 222
Опубликована: Март 31, 2025
The growing demand for real-time, non-invasive, and cost-effective health monitoring has driven significant advancements in portable point-of-care testing (POCT) devices. Among these, optical biosensors have emerged as promising tools the detection of critical biomarkers such uric acid (UA) blood glucose. Different transduction methods, like fluorescence, surface plasmon resonance (SPR), colorimetric approaches, are talked about, with a focus on how sensitive, specific, they are. Despite considerable advancements, several challenges persist, including sensor stability, miniaturization, interference effects, need calibration-free operation. This review also explores issues related to cost-effectiveness, data integration, wireless connectivity remote monitoring. further examines regulatory considerations commercialization aspects biosensors, addressing gap between research developments clinical implementation. Future perspectives emphasize integration artificial intelligence (AI) healthcare improved diagnostics, alongside development wearable implantable continuous Innovative potential change way people manage their by quickly accurately measuring glucose levels. is especially true decentralized solutions grows. By critically evaluating existing work exploring limitations opportunities field, this will help guide more efficient, accessible, reliable POCT devices that can improve patient outcomes quality life.
Язык: Английский
Процитировано
0
Food and Bioprocess Technology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Micromachines, Год журнала: 2024, Номер 15(9), С. 1116 - 1116
Опубликована: Авг. 31, 2024
Alpha-fetoprotein (AFP) is a key marker for early cancer detection and assessment. However, the current methods struggle to balance accuracy with need decentralized medical treatment. To address this issue, new AFP analysis platform utilizing digital image colorimetry has been developed. Functionalized gold nanoparticles act as colorimetric agents, changing from purple-red light gray-blue when exposed different concentrations. A smartphone app captures these color changes calculates concentration in sample. improve accuracy, hardware device ensures uniform illumination. Testing confirmed that system can quantitatively analyze using colorimetry. The limit of reached 0.083 ng/mL, average 90.81%. This innovative method enhances testing by offering portability, precision, low cost, making it particularly suitable resource-limited areas.
Язык: Английский
Процитировано
3
Microchimica Acta, Год журнала: 2024, Номер 191(11)
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
1
Microchimica Acta, Год журнала: 2024, Номер 191(11)
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
1
Analytical Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Pressure-based signal transduction is of promise in developing microfluidic immunoassays such as volumetric bar-chart chips (V-chips), but new working principles are required to further simplify the methods point-of-care testing (POCT). Herein, we developed immunosyringe sensors and integrated them with for simple prick-and-read prostate specific antigen (PSA) a model target. Disposable syringes served host construction sandwich-type immuno-recognition system. Platinum nanoparticles (Pt NPs) peroxidase-mimicking detection probe catalyzed decomposition H2O2 produce O2 syringe cylinders, enabling pressure-driven automatic injection liquids from syringes. The event was thereby converted into quantitative autoinjection behavior syringes, namely, sensors. By simply pricking chips, visually quantitatively read immunoassay signals distance channels chips. showed limit (LOD) 0.41 ng/mL PSA satisfactory accuracy clinical serum samples. Owing integration sensors, this method, comparison conventional V-chips, works simpler manner without complex chip configurations specialized operations (e.g., on-chip loading microvolume reagents sealing treatments). Therefore, shows great potential POCT applications.
Язык: Английский
Процитировано
1
Microchimica Acta, Год журнала: 2024, Номер 191(11)
Опубликована: Окт. 7, 2024
Язык: Английский
Процитировано
0