Food Chemistry, Год журнала: 2025, Номер 485, С. 144459 - 144459
Опубликована: Апрель 25, 2025
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(38)
Опубликована: Авг. 9, 2024
Dual-mode readout platforms with colorimetric and electrochemiluminescence (ECL) signal enhancement are proposed for the ultrasensitive flexible detection of monkeypox virus (MPXV) in different scenes. A new nanotag, Ru@U6-Ru/Pt NPs is constructed dual-mode by integrating double-layered ECL luminophores nanozyme using Zr-MOF (UiO-66-NH
Язык: Английский
Процитировано
44
Critical Reviews in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 25
Опубликована: Сен. 17, 2024
This comprehensive review delves into the advancements and challenges in biosensing, with a strong emphasis on transformative potential of CRISPR technology for early rapid detection infectious diseases. It underscores versatility CRISPR/Cas systems, highlighting their ability to detect both nucleic acids non-nucleic acid targets, seamless integration isothermal amplification techniques. The provides thorough examination latest developments CRISPR-based biosensors, detailing unique properties such as high specificity programmability, which make them particularly effective detecting disease-associated acids. While focuses due its critical role diagnosing diseases, it also explores broader applications thereby acknowledging technology's potential. Additionally, identifies existing challenges, need improved signal real-world applicability, offers future perspectives aimed at overcoming these hurdles. ultimate goal is advance development highly sensitive specific biosensors that can be used widely improving human health, point-of-care settings resource-limited environments.
Язык: Английский
Процитировано
15
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Дек. 2, 2024
ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.
Язык: Английский
Процитировано
13
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(10)
Опубликована: Окт. 1, 2024
ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.
Язык: Английский
Процитировано
12
Materials Today Sustainability, Год журнала: 2024, Номер unknown, С. 101068 - 101068
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
11
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160553 - 160553
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(2)
Опубликована: Фев. 1, 2025
ABSTRACT The integration of MXenes into electrospun fibers represents a significant leap forward in advancing biomedical applications. This review delves the synergistic combination and fibers, highlighting their multifaceted capabilities tissue engineering, drug delivery, antimicrobial activity, cancer therapy, biosensing. Exceptional properties MXene, including electrical conductivity, hydrophilicity, mechanical robustness, surface tunability, offer unique advantages when incorporated nanofibrous scaffolds. By enhancing strength, promoting cellular interactions, enabling targeted therapeutic functions, MXene‐based demonstrate immense potential addressing critical challenges biomedicine. provides comprehensive overview recent advances MXene synthesis, incorporation matrices, applications, while also identifying future directions this emerging field.
Язык: Английский
Процитировано
2
Digital Health, Год журнала: 2025, Номер 11
Опубликована: Янв. 1, 2025
To develop an enhanced deep learning model, MRpoxNet, based on a modified ResNet50 architecture for the early detection of monkeypox from digital skin lesion images, ensuring high diagnostic accuracy and clinical reliability. The study utilized Kaggle MSID dataset, initially comprising 1156 augmented to 6116 images across three classes: monkeypox, non-monkeypox, normal skin. MRpoxNet was developed by extending 177 182 layers, incorporating additional convolutional, ReLU, dropout, batch normalization layers. Performance evaluated using metrics such as accuracy, precision, recall, F1 score, sensitivity, specificity. Comparative analyses were conducted against established models like ResNet50, AlexNet, VGG16, GoogleNet. achieved 98.1%, outperforming baseline in all key metrics. demonstrated superior robustness distinguishing lesions other conditions, highlighting its potential reliable application. provides robust efficient solution detection. Its performance suggests readiness integration into workflows, with future enhancements aimed at dataset expansion multimodal adaptability diverse scenarios.
Язык: Английский
Процитировано
1
Coordination Chemistry Reviews, Год журнала: 2024, Номер 523, С. 216294 - 216294
Опубликована: Окт. 29, 2024
Язык: Английский
Процитировано
7
Small Structures, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
To effectively address crisis emergence of new virus such as monkeypox, a collective and collaborative effort between scientists, engineers, innovators, artists from all ages, regions, diverse fields is required. This review explores holistic approach to addressing the monkeypox by integrating nanobiosensors, artificial intelligence, visual arts, humanities, social sciences. Traditional diagnostic methods are often limited time, accessibility, accuracy, but advancement point‐of‐care smart nanobiosensors offers promising shift toward rapid, precise, accessible diagnostics. They enhance ability screen, diagnose, monitor infections efficiently, contributing better disease management. Beyond technological innovation, essential role sciences in fostering public engagement, understanding, acceptance tools emphasized. Visual arts can illustrate scientific concepts, making them more relatable, while storytelling through various media reduce stigma promote preventive measures. Social provide insights into cultural attitudes, behaviors, health challenges, ensuring that solutions integrated communities. By combining these disciplines, this presents comprehensive framework for resilient global system aligns with One Health principles, emphasizing interconnectedness human, animal, environmental health.
Язык: Английский
Процитировано
1