Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor Heterogeneity DOI Open Access
Yuntian Zhang

Опубликована: Окт. 23, 2023

Tumor heterogeneity is a major obstacle to achieving consistent outcomes in cancer therapy. Here, we present new perspective on tumor heterogeneity. The foundation for understanding lies recognizing that evolution process driven by cells responding survival challenges, and this cellular response precipitates the development of hallmark capabilities. We posit arises from cells’ continued capabilities, which ultimately leads increased molecular chaos. Therapeutic inhibition essential genes driving disease can disrupt evolution, leading cell death, phenomenon termed oncogene addiction. Drawing same idea respond introduce notion increasing primitiveness during its progress stems continuous need regeneration due sustained damage. To expand our concept heterogeneity, further explore redefining key based levels, propose potential treatment strategy advanced-stage cancers inducing aging-related deterioration. Taken together, notions explored herein pave way novel therapies betterment human health.

Язык: Английский

Metabolic communication in the tumour–immune microenvironment DOI
Kung‐Chi Kao,

Stefania Vilbois,

Chin‐Hsien Tsai

и другие.

Nature Cell Biology, Год журнала: 2022, Номер 24(11), С. 1574 - 1583

Опубликована: Окт. 13, 2022

Язык: Английский

Процитировано

191
Update on Epithelial-Mesenchymal Plasticity in Cancer Progression DOI Creative Commons
Rosa Fontana, Aida Mestre‐Farrera, Jing Yang

и другие.

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2023, Номер 19(1), С. 133 - 156

Опубликована: Сен. 27, 2023

Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose their characteristics and acquire mesenchymal traits to promote cell movement. This program aberrantly activated in human cancers endows tumor with increased abilities initiation, migration, invasion, metastasis, therapy resistance. The EMT tumors rarely binary often leads series of gradual or intermediate epithelial-mesenchymal states. Functionally, plasticity (EMP) improves the fitness cancer during progression response therapies. Here, we discuss most recent advances our understanding diverse roles EMP progression, resistance address major clinical challenges due EMP-driven phenotypic heterogeneity cancer. Uncovering novel molecular markers key regulators will aid development new therapeutic strategies prevent recurrence overcome

Язык: Английский

Процитировано

58
Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Язык: Английский

Процитировано

7
Dissecting metastasis using preclinical models and methods DOI

Jess D. Hebert,

Joel W. Neal, Monte M. Winslow

и другие.

Nature reviews. Cancer, Год журнала: 2023, Номер 23(6), С. 391 - 407

Опубликована: Май 3, 2023

Язык: Английский

Процитировано

43
The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence DOI
Bashar A. Alhasan, А. В. Морозов, Irina V. Guzhova

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(4), С. 189119 - 189119

Опубликована: Май 16, 2024

Язык: Английский

Процитировано

8
The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis DOI Creative Commons

Pei Yu,

Yubao Han,

Lulu Meng

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 25, 2024

Abstract Triple-negative breast cancer (TNBC) stands as the subtype with highest recurrence and mortality rates, lungs being common site of metastasis. The pulmonary microenvironment plays a pivotal role in colonization disseminated tumor cells. Herein, this study highlights crucial exosomal LAP-TGF-β1, principal form TGF-β1, reshaping vascular niche, thereby facilitating TNBC lung Although various strategies have been developed to block TGF-β signaling advanced clinically, their significant side effects limited therapeutic application. This demonstrates that metastatic sites, LAP-TGF-β1 within exosomes can remarkably reconfigure niche at lower doses, bolstering extravasation cells lungs. Mechanistically, under aegis acetyltransferase TIP60, non-canonical KFERQ-like sequence undergoes acetylation K304 site, promoting its interaction HSP90A subsequent transport into exosomes. Concurrent inhibition both TIP60 significantly diminishes burden presenting promising avenue for not only offers fresh insights molecular underpinnings metastasis but also lays foundation innovative strategies.

Язык: Английский

Процитировано

7
Dynamic links between mechanical forces and metabolism shape the tumor milieu DOI Creative Commons
Rebecca Bertolio, Francesco Napoletano, Giannino Del Sal

и другие.

Current Opinion in Cell Biology, Год журнала: 2023, Номер 84, С. 102218 - 102218

Опубликована: Авг. 17, 2023

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all physiopathological processes tissues, mechanical forces impact structure and membranes, enzymes, organelles regulators gene programs, thus regulating cell metabolism. turn, pathways feedback impacts physical properties tissues. Hence, metabolism tissue mechanics are dynamically intertwined continuously interact. Cancer is akin to an ecosystem, comprising tumor cells various subpopulations stromal embedded in altered extracellular matrix. The progression cancer, from initiation advanced stage metastasis, driven by genetic mutations crucially influenced alterations microenvironment. These also play a pivotal role cancer evasion immune surveillance developing resistance treatments. Here, we highlight emerging evidence showing that mechano-metabolic circuits regulate multiple crucial for discuss potential approaches improve therapeutic treatments interfering with these circuits.

Язык: Английский

Процитировано

12
Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR DOI Creative Commons
Harald Schuhwerk, Thomas Brabletz

Seminars in Cancer Biology, Год журнала: 2023, Номер 97, С. 86 - 103

Опубликована: Ноя. 28, 2023

Язык: Английский

Процитировано

12
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer DOI Creative Commons
Bin Luo, Zujun Que,

Xinyi Lu

и другие.

Biological Procedures Online, Год журнала: 2023, Номер 25(1)

Опубликована: Ноя. 13, 2023

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary have higher survival rates than those Thus, it is imperative discover biomarkers the early detection NSCLC and timely prediction tumor metastasis improve patient outcomes.

Язык: Английский

Процитировано

11
Tumor immune microenvironment-modulated nanostrategy for the treatment of lung cancer metastasis DOI Creative Commons
Lingling Zhu,

Juan Wu,

Honglin Gao

и другие.

Chinese Medical Journal, Год журнала: 2023, Номер unknown

Опубликована: Июль 10, 2023

Abstract As one of the most malignant tumors worldwide, lung cancer, fueled by metastasis, has shown rising mortality rates. However, effective clinical strategies aimed at preventing metastasis are lacking owing to its dynamic multi-step, complicated, and progressive nature. Immunotherapy promise in treating cancer reversing immunosuppressive network tumor microenvironment. drug resistance inevitably develops due inadequate delivery immunostimulants an uncontrolled immune response. Consequently, adverse effects occur, such as autoimmunity, from non-specific activation inflammation off-target organs. Nanocarriers that improve solubility, permeability, stability, bioavailability, well sustained, controlled, targeted can effectively overcome enhance therapeutic effect while reducing effects. In particular, nanomedicine-based immunotherapy be utilized target presenting a promising strategy for cancer. Nanotechnology boost classified based on metastatic cascade related microenvironment; breaking away primary tumors, circulating cell dissemination, premetastatic niche formation cause distant secondary site colonization. this review, we focus opportunities challenges integrating with nanoparticle formulation establish nanotechnology-based modulating microenvironment preclinical applications management patients We also discuss prospects emerging field translation potential these techniques.

Язык: Английский

Процитировано

9