Advancements in Understanding the Hide-and-Seek Strategy of Hibernating Breast Cancer Cells and Their Implications in Oncology from a Broader Perspective: A Comprehensive Overview DOI Creative Commons

Aiman Al-Ruwishan,

Bushra Amer,

Ahmed F. Salem

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8340 - 8367

Published: Aug. 1, 2024

Despite recent advancements in technology, breast cancer still poses a significant threat, often resulting fatal consequences. While early detection and treatments have shown some promise, many patients continue to struggle with the persistent fear of disease returning. This is valid, as cells can lay dormant for years before remerging, evading traditional like game hide seek. The biology these presents crucial yet poorly understood challenge clinical settings. In this review, we aim explore mysterious world their impact on patient outcomes prognosis. We shed light elusive role G9a enzyme other epigenetic factors recurrence, highlighting its potential target eliminating preventing relapse. Through comprehensive not only emphasise urgency unravelling dynamics improve advance personalised oncology but also provide guide fellow researchers. By clearly outlining research gaps surrounding from molecular perspective, inspire further exploration critical area, ultimately leading improved care treatment strategies.

Language: Английский

Metabolic communication in the tumour–immune microenvironment DOI
Kung‐Chi Kao,

Stefania Vilbois,

Chin‐Hsien Tsai

et al.

Nature Cell Biology, Journal Year: 2022, Volume and Issue: 24(11), P. 1574 - 1583

Published: Oct. 13, 2022

Language: Английский

Citations

178
Update on Epithelial-Mesenchymal Plasticity in Cancer Progression DOI Creative Commons
Rosa Fontana, Aida Mestre‐Farrera, Jing Yang

et al.

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2023, Volume and Issue: 19(1), P. 133 - 156

Published: Sept. 27, 2023

Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose their characteristics and acquire mesenchymal traits to promote cell movement. This program aberrantly activated in human cancers endows tumor with increased abilities initiation, migration, invasion, metastasis, therapy resistance. The EMT tumors rarely binary often leads series of gradual or intermediate epithelial-mesenchymal states. Functionally, plasticity (EMP) improves the fitness cancer during progression response therapies. Here, we discuss most recent advances our understanding diverse roles EMP progression, resistance address major clinical challenges due EMP-driven phenotypic heterogeneity cancer. Uncovering novel molecular markers key regulators will aid development new therapeutic strategies prevent recurrence overcome

Language: Английский

Citations

52
Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
Dissecting metastasis using preclinical models and methods DOI

Jess D. Hebert,

Joel W. Neal, Monte M. Winslow

et al.

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(6), P. 391 - 407

Published: May 3, 2023

Language: Английский

Citations

41
The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence DOI
Bashar A. Alhasan, А. В. Морозов, Irina V. Guzhova

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(4), P. 189119 - 189119

Published: May 16, 2024

Language: Английский

Citations

7
The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis DOI Creative Commons

Pei Yu,

Yubao Han,

Lulu Meng

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 25, 2024

Abstract Triple-negative breast cancer (TNBC) stands as the subtype with highest recurrence and mortality rates, lungs being common site of metastasis. The pulmonary microenvironment plays a pivotal role in colonization disseminated tumor cells. Herein, this study highlights crucial exosomal LAP-TGF-β1, principal form TGF-β1, reshaping vascular niche, thereby facilitating TNBC lung Although various strategies have been developed to block TGF-β signaling advanced clinically, their significant side effects limited therapeutic application. This demonstrates that metastatic sites, LAP-TGF-β1 within exosomes can remarkably reconfigure niche at lower doses, bolstering extravasation cells lungs. Mechanistically, under aegis acetyltransferase TIP60, non-canonical KFERQ-like sequence undergoes acetylation K304 site, promoting its interaction HSP90A subsequent transport into exosomes. Concurrent inhibition both TIP60 significantly diminishes burden presenting promising avenue for not only offers fresh insights molecular underpinnings metastasis but also lays foundation innovative strategies.

Language: Английский

Citations

5
Dynamic links between mechanical forces and metabolism shape the tumor milieu DOI Creative Commons
Rebecca Bertolio, Francesco Napoletano, Giannino Del Sal

et al.

Current Opinion in Cell Biology, Journal Year: 2023, Volume and Issue: 84, P. 102218 - 102218

Published: Aug. 17, 2023

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all physiopathological processes tissues, mechanical forces impact structure and membranes, enzymes, organelles regulators gene programs, thus regulating cell metabolism. turn, pathways feedback impacts physical properties tissues. Hence, metabolism tissue mechanics are dynamically intertwined continuously interact. Cancer is akin to an ecosystem, comprising tumor cells various subpopulations stromal embedded in altered extracellular matrix. The progression cancer, from initiation advanced stage metastasis, driven by genetic mutations crucially influenced alterations microenvironment. These also play a pivotal role cancer evasion immune surveillance developing resistance treatments. Here, we highlight emerging evidence showing that mechano-metabolic circuits regulate multiple crucial for discuss potential approaches improve therapeutic treatments interfering with these circuits.

Language: Английский

Citations

12
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer DOI Creative Commons
Bin Luo, Zujun Que,

Xinyi Lu

et al.

Biological Procedures Online, Journal Year: 2023, Volume and Issue: 25(1)

Published: Nov. 13, 2023

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary have higher survival rates than those Thus, it is imperative discover biomarkers the early detection NSCLC and timely prediction tumor metastasis improve patient outcomes.

Language: Английский

Citations

11
Dormant Tumor Cells: Current Opportunities and Challenges in Clinical Practice DOI Creative Commons

Emma Boydell,

Maxime Borgeaud, Petros Tsantoulis

et al.

Onco, Journal Year: 2025, Volume and Issue: 5(1), P. 3 - 3

Published: Jan. 10, 2025

Tumor dormancy plays a pivotal role in cancer relapse. Dormant tumor cells have been identified distant sites, even early-stage tumors, and are associated with worse outcomes. This review explores the current understanding of molecular cellular mechanisms behind dormancy, including immune system microenvironment. Targeting dormant could be therapeutic strategy to offer long-term remission potentially cure cancer. Unfortunately, translation this knowledge clinical practice is lacking. We assess feasibility detecting measuring practice, give an overview potential targets, both terms maintaining state, eradicating population.

Language: Английский

Citations

0
Exosome tropism and various pathways in lung cancer metastasis DOI Creative Commons
Hui Chen, Lin Liu, Gang Xing

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Lung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize various organs, thereby amplifying detrimental impact fatality. The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication regulating functions due their specificity stability. Extensive research elucidated production exosomes contexts. Multitude evidence demonstrates strong association between exosomes. Additionally, concept pre-metastatic niche crucial metastatic process facilitated This review emphasizes role on disease’s development progression other tissues. Furthermore, it explores potential as biomarkers for metastasis, offering significant insights future clinical advancements.

Language: Английский

Citations

0