Green Chemistry, Год журнала: 2022, Номер 25(1), С. 431 - 438
Опубликована: Ноя. 25, 2022
Herein, a yeast cell, with neither photosynthetic properties nor hydrogen production abilities, is endowed efficient solar-to-chemical via in situ biosynthesized intracellular nanodots triggering enzyme-catalyzed reactions.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(10), С. 5304 - 5304
Опубликована: Май 10, 2022
Harnessing enzymes which possess several catalytic activities is a topic where intense research has been carried out, mainly coupled with the development of cascade reactions. This review tries to cover different possibilities reach this goal: promiscuous activities, fusion enzymes, + metal catalysts (including nanoparticles or site-directed attached organometallic catalyst), bearing non-canonical amino acids catalysts, design second biological but artificial active center (plurizymes) by coupling enzyme modelling and directed mutagenesis plurizymes that have site modified in both just one an irreversible inhibitor catalyst. Some examples reactions catalyzed are also described. Finally, some foreseen problems use these multi-activity described (mainly related balance necessary many instances, operational stabilities activities). The new (e.g., plurizymes) seems be unarguable interest, as may link non-biological establish combo-catalysis routes.
Язык: Английский
Процитировано
22
Results in Chemistry, Год журнала: 2023, Номер 6, С. 101172 - 101172
Опубликована: Окт. 18, 2023
Nanocomposites play vital role as catalyst during organic reactions because of high aspect ratio and greater surface area nanostructured materials. The strong interfacial interaction reactant with the nanocomposites reaction gives an enhancement in rate yield product. present review reveals a critical analysis regarding function transition metal based catalytic action various reactions. Catalytic combination other carbon nanomaterials, polymeric materials well metals or oxides are extensively elaborated this review. change yields, duration reaction, atom economy, effect solvent along selectivity monitored by nanocomposites. Reduction, oxidation, epoxidation, hydrogenation, halogenation coupling appreciably reviewed considering these different nanocatalysts known name chemistry is also studied. Hence, explores new methods using catalysts following principle green replacing traditional reagents synthesis.
Язык: Английский
Процитировано
12
Enzyme and Microbial Technology, Год журнала: 2024, Номер 180, С. 110483 - 110483
Опубликована: Июль 17, 2024
Язык: Английский
Процитировано
5
European Journal of Organic Chemistry, Год журнала: 2022, Номер 26(3)
Опубликована: Сен. 9, 2022
Abstract A Deep Eutectic Solvent, choline chloride/glycerol (1 : 2 mol −1 ), proved to be an effective and sustainable reaction medium promote telescoped, one‐pot Mizoroki‐Heck cross‐coupling/reduction processes between 2,3‐dihydrofuran or 3,4‐dihydro‐2 H ‐pyran several (hetero)aryl halides easily access valuable 2‐(hetero)aryl tetrahydrofuran (THF) tetrahydropyran derivatives in up 95 % yield. Notably, the whole transformation takes place under aerobic conditions, absence of additional ligands, with a good substrate scope. The practicability method is also exemplified by synthesis two key THF derivatives, which are side chains pharmacologically relevant inhibitors Kv1.2 channel.
Язык: Английский
Процитировано
17
Angewandte Chemie, Год журнала: 2023, Номер 135(18)
Опубликована: Фев. 6, 2023
Abstract The combination of catalytic methods provides multiple advantages in organic synthesis, allowing access to diverse molecules a straightforward manner. Merging metal and enzyme catalysis is currently receiving great attention due the possibility assemble C−C coupling, olefin metathesis, hydration other reactions with exquisite stereospecificity displayed by enzymes. Thus, this minireview organized based on action species (Pd, Ru, Au, Ir, Fe…) different Special will be paid design sequential processes concurrent cascades, presenting solutions such as use surfactants or compartmentalization strategies for those cases where incompatibilities could hamper overall process.
Язык: Английский
Процитировано
10
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(24)
Опубликована: Янв. 13, 2024
Combining chemo- and biocatalysis enables the design of novel economic sustainable one-pot processes for preparation industrial chemicals, preferably proceeding in water. While a range proofs-of-concept compatibility such catalysts from these two different "worlds catalysis" have recently been demonstrated, merging noncompatible biocatalysts joint applications within one reactor remained challenge. A conceptual solution is compartmentalization catalytic moieties by heterogenization critical catalyst components, thus "shielding" them complementary catalyst, substrate or reagent. Exemplified process consisting metal-catalyzed Wacker oxidation enzymatic reduction as individual reactions steps, we demonstrate that making use 3D printing heterogeneous materials containing Cu metal component can overcome incompatibility hurdles. The application 3D-printed Cu-ceramic device allows an efficient combination with enzyme desired two-step transformation styrene into chiral alcohol product high overall conversion excellent enantioselectivity. This concept based on heterogenized represents scalable methodology opens up numerous perspectives to be used general tool also other related chemoenzymatic research challenges.
Язык: Английский
Процитировано
4
Advanced Synthesis & Catalysis, Год журнала: 2022, Номер 364(22), С. 3856 - 3866
Опубликована: Окт. 3, 2022
Abstract The compatibility between gold(I) catalysts and amine transaminases has been explored to transform racemic propargylic alcohols into enantioenriched allylic amines in a straightforward selective manner. synthetic approach consists of gold(I)‐catalysed Meyer‐Schuster rearrangement series 2‐arylpent‐3‐yn‐2‐ols subsequent stereoselective enzyme‐catalysed transamination the resulting α,β‐unsaturated prochiral ketones. design cascade processes involving sequential or concurrent approaches studied our search for ideal reaction conditions produce desired amines. Thus, N‐heterocyclic carbene complex [1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene]‐[bis(trifluoromethanesulfonyl)‐imide]gold(I) ([Au(IPr)(NTf 2 )] ( A ) aqueous medium was found be an catalyst, while selective, made‐in‐house commercial permitted asymmetric synthesis both E )‐4‐arylpent‐3‐en‐2‐amine enantiomers good isolated yields (53–84%) excellent stereoselectivities (97 >99% enantiomeric excess). magnified image
Язык: Английский
Процитировано
16
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(9), С. 2579 - 2584
Опубликована: Янв. 1, 2024
A protocol for iodine( iii )-mediated oxidative chlorination, bromination and iodination of chromone derivatives has been developed using alkyl halide solvents such as CHCl 3 , CH 2 Br I the halogen source.
Язык: Английский
Процитировано
3
ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 22, 2024
Direct conversion of inexpensive fructose into value-added furanic chemicals via chemobiocatalytic cascades is a highly attractive yet challenging task due to the incompatibility issues between chemo- and biocatalysts. Among issues, solvent crucial make two worlds catalysts work well in one pot. In this work, we present an enzyme-friendly natural deep eutectic (NADES)-based medium for one-pot valorization valuable furanics 5-hydroxymethylfurfural (HMF). HMF was obtained with approximately 40% yield 64% selectivity within 1.5 h under 150 °C 15 wt % NADES (choline chloride/oxalic acid, 1:1, mol/mol) aqueous solution. significantly improved 91% by applying vol methyl isobutyl ketone/NADES biphasic medium. A NADES/unreacted recycle process designed improve both overall (77%) (72%). The NADES-based benign toward various biocatalysts such as alcohol aldehyde dehydrogenases, acyltransferase, ω-transaminase, evidenced good yields (86–97%) desired products subsequent biotransformations. Specifically, 2,5-bis(hydroxymethyl)furan from 41% isolated gram-scale synthesis. This may lay foundation sustainable manufacture high-value biomass.
Язык: Английский
Процитировано
3
ACS Catalysis, Год журнала: 2025, Номер unknown, С. 2484 - 2491
Опубликована: Янв. 27, 2025
Au(I)-catalyzed hydration of aliphatic terminal alkynes is followed by transaminase-catalyzed reductive amination, leading to enantioenriched chiral amines. The approach features a one-pot reaction with no particular need for compartmentalization strategy. Final functionalization performed in situ leads variety amines, pyrroles, and 1-pyrrolines obtained high enantioselectivities. method demonstrates applicability the synthesis bioactive drugs such as clobenzorex (43% yield, 3 steps, 96% ee) precursor lisdexamfetamine (34% dr 98:2).
Язык: Английский
Процитировано
0