Coronavirus spike protein-based vaccines. Vaccine delivery systems DOI Creative Commons
Akmal M. Asrorov, Mirzakamol S. Ayubov, Bin Tu

и другие.

Medicine in Drug Discovery, Год журнала: 2024, Номер unknown, С. 100198 - 100198

Опубликована: Сен. 1, 2024

Язык: Английский

A phase I study of the safety, reactogenicity and immunogenicity of two quadrivalent seasonal influenza vaccines (Fluzone® or Flublok®) with or without one of two adjuvants (AF03 or Advax-CpG55.2) in healthy adults 18–45 years of age DOI
Theresa Hegmann, Emmanuel B. Walter, Michael J. Smith

и другие.

Vaccine, Год журнала: 2025, Номер 54, С. 126991 - 126991

Опубликована: Март 18, 2025

Язык: Английский

Процитировано

0
Advax-CpG55.2-adjuvanted monovalent or trivalent SARS-CoV-2 recombinant spike protein vaccine protects hamsters against heterologous infection with Beta or Delta variants DOI Creative Commons
Yoshikazu Honda‐Okubo, Richard A. Bowen,

Mckinzee Barker

и другие.

Vaccine, Год журнала: 2023, Номер 41(48), С. 7116 - 7128

Опубликована: Окт. 19, 2023

Язык: Английский

Процитировано

8
Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines DOI Creative Commons
Pedro L. Sánchez, Greiciely O. André, Anna Antipov

и другие.

Vaccines, Год журнала: 2024, Номер 12(5), С. 455 - 455

Опубликована: Апрель 24, 2024

Adjuvants enhance immune responses stimulated by vaccines. To date, many seasonal influenza vaccines are not formulated with an adjuvant. In the present study, adjuvant Advax-SM™ was combined next generation, broadly reactive hemagglutinin (HA) that were designed using a computationally optimized antigen (COBRA) methodology. is novel comprising inulin polysaccharide and CpG55.2, TLR9 agonist. COBRA HA or comparator squalene emulsion (SE) administered to mice intramuscularly. Mice vaccinated adjuvanted had increased serum levels of anti-influenza IgG IgA, high hemagglutination inhibition activity against panel H1N1 H3N2 viruses, antibody secreting cells isolated from spleens. plus immunized protected both morbidity mortality following viral challenge and, at postmortem, no detectable lung titers inflammation. Overall, Advax-SM™-adjuvanted formulation provided effective protection drifted viruses.

Язык: Английский

Процитировано

2
Comparative immunogenicity and safety of SpikoGen®, a recombinant SARS-CoV-2 spike protein vaccine in children and young adults: An immuno-bridging clinical trial DOI
Payam Tabarsi, Setareh Mamishi, Nassim Anjidani

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 127, С. 111436 - 111436

Опубликована: Дек. 25, 2023

Язык: Английский

Процитировано

5
Coronavirus spike protein-based vaccines. Vaccine delivery systems DOI Creative Commons
Akmal M. Asrorov, Mirzakamol S. Ayubov, Bin Tu

и другие.

Medicine in Drug Discovery, Год журнала: 2024, Номер unknown, С. 100198 - 100198

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0