Biotechnology Advances,
Год журнала:
2024,
Номер
unknown, С. 108492 - 108492
Опубликована: Дек. 1, 2024
The
prevalence
of
multidrug-resistant
(MDR)
ESKAPE
pathogens,
including
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
and
Pseudomonas
aeruginosa,
represents
a
critical
global
public
health
challenge.
In
response,
mRNA
vaccines
offer
an
adaptable
scalable
platform
for
immunotherapy
against
pathogens
by
encoding
specific
antigens
that
stimulate
B-cell-driven
antibody
production
CD8
Annals of Medicine,
Год журнала:
2025,
Номер
57(1)
Опубликована: Янв. 10, 2025
Background
The
incidence
of
invasive
infection
Klebsiella
pneumoniae
(Kp)
in
the
community
is
increasing
every
year,
and
high
disability
mortality
rates
associated
with
them
pose
great
challenges
clinical
practice.
This
study
aimed
to
explore
microbiological
characteristics
Kp
community.
Clinical Microbiology Reviews,
Год журнала:
2024,
Номер
37(3)
Опубликована: Авг. 9, 2024
SUMMARY
Healthcare-associated
infections
(HAIs)
represent
a
burden
for
public
health
with
high
prevalence
and
death
rates
associated
them.
Pathogens
potential
antimicrobial
resistance,
such
as
ESKAPE
pathogens
(
E
nterococcus
faecium,
S
taphylococcus
aureus,
K
lebsiella
pneumoniae,
A
cinetobacter
baumannii,
P
seudomonas
aeruginosa,
nterobacter
species
)
Clostridioides
difficile
,
are
responsible
most
HAIs.
Despite
the
implementation
of
infection
prevention
control
intervention,
globally,
HAIs
is
stable
they
mainly
due
to
endogenous
pathogens.
It
undeniable
that
complementary
measures,
prophylactic
approaches
by
active
or
passive
immunization
needed.
Specific
groups
at-risk
(elderly
people,
chronic
condition
immunocompromised)
also
healthcare
workers
key
targets.
Medical
procedures
specific
interventions
known
be
at
risk
HAIs,
in
addition
hospital
environmental
exposure.
Vaccines
monoclonal
antibodies
can
seen
attractive
preventive
In
this
review,
we
present
an
overview
vaccines
clinical
development
major
bacterial
Based
on
current
state
knowledge,
look
challenges
future
perspectives
improve
these
means.
Wellcome Open Research,
Год журнала:
2025,
Номер
10, С. 5 - 5
Опубликована: Янв. 13, 2025
The
increasing
threat
from
infection
with
drug-resistant
pathogens
is
among
the
most
serious
public
health
challenges
of
our
time.
Formed
by
Wellcome
in
2018,
Surveillance
and
Epidemiology
Drug-Resistant
Infections
Consortium
(SEDRIC)
an
international
think
tank
whose
aim
to
inform
policy
change
way
countries
track,
share,
analyse
data
relating
infections,
defining
knowledge
gaps
identifying
barriers
delivery
global
surveillance.
SEDRIC
delivers
its
aims
through
discussions
analyses
world-leading
scientists
that
result
recommendations
advocacy
others.
As
a
result,
has
made
key
contributions
furthering
national
actions.
Here,
we
look
back
at
work
consortium
between
2018-2024,
highlighting
notable
successes.
We
provide
specific
examples
where
technical
have
helped
funding
priorities
will
real-world
impact
on
surveillance
epidemiology
infections
pathogens.
The Lancet Microbe,
Год журнала:
2025,
Номер
unknown, С. 100988 - 100988
Опубликована: Фев. 1, 2025
Klebsiella
pneumoniae
is
a
leading
cause
of
infection-related
deaths
globally,
yet
little
known
about
human
antibody
responses
to
invasive
K
pneumoniae.
We
sought
determine
whether
the
O-specific
polysaccharide
antigen
immunogenic
in
humans
with
bloodstream
infection.
also
define
cross-reactivity
among
structurally
related
subtypes
and
assess
effect
capsule
production
on
polysaccharide-targeted
binding
function.
In
this
prospective
cohort
study,
we
compared
plasma
consecutively
enrolled
patients
infection
controls,
specifically
healthy
individuals
Enterococcus
spp
Patients
were
at
Massachusetts
General
Hospital,
tertiary
hospital
affiliated
clinics
USA.
excluded
whose
isolates
not
confirmed
be
by
whole-genome
sequencing.
The
primary
outcome
was
measurement
IgG,
IgM,
IgA
responses.
performed
flow
cytometry
measure
effects
antibody-mediated
complement
deposition,
using
patient
variable
levels
isogenic
capsule-deficient
strains
derived
from
these
isolates.
129
consecutive
suspected
between
July
24,
2021,
August
4,
2022,
whom
69
(44
[64%]
male
25
[36%]
female)
eligible
for
immunological
evaluation.
Common
serotypes
(O1,
O2,
O3,
O5)
accounted
57
(83%)
infections.
infection,
peak
polysaccharide-IgG
ten-fold
30-fold
higher
than
detected
depending
serotype.
There
similar
subtypes,
including
O1v1
O1v2,
O2v1
O2v2,
O3
O3b
as
well
O1
O2
types.
Capsule
produced
both
hyperencapsulated
non-hyperencapsulated
inhibited
supporting
its
potential
candidate
vaccine
antigen.
observed
suggests
that
it
might
necessary
include
all
an
polysaccharide-based
vaccine.
However,
observations
are
tempered
fact
production,
even
non-highly
encapsulated
strains,
has
interfere
binding.
This
finding
could
limit
effectiveness
vaccines
exclusively
target
polysaccharide.
National
Institute
Allergy
Infectious
Diseases
Institutes
Health.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 7, 2025
Abstract
Klebsiella
pneumoniae
(KPn)
colonizes
multiple
anatomical
sites
and
is
a
leading
cause
of
invasive
disease
death
in
African
children;
however,
there
no
comparative
genomic
analysis
between
colonizing
strains.
This
study
investigated
the
relatedness
KPn
isolates
South
infants;
evaluated
relative
invasiveness
based
on
sequence
types
(ST),
capsular
(KL),
lipopolysaccharide
(O)
loci
by
calculating
case-carrier
ratios
(CCRs).
There
was
less
diversity
amongst
(22
ST,
17
K-loci)
than
(31
29
K-loci),
with
being
8.59-fold
3.49-fold
more
likely
to
harbour
genes
encoding
for
multi-drug
resistance
yersiniabactin
production
compared
isolates.
The
CCRs
KL102
O1/O2v2
were
>
1,
<
1
KL8,
ST1414,
O1O2v1.
Identifying
high-risk
strains,
including
O1O2v2,
that
may
have
higher
potential
disease,
could
enhance
risk
assessment
management
strategies
vulnerable
populations.
Microbiology and Molecular Biology Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
SUMMARY
Klebsiella
pneumoniae
is
a
gram-negative
species,
whose
isolates
are
found
in
the
environment
and
as
commensals
human
gastrointestinal
tract.
This
bacterium
among
leading
causes
of
range
nosocomial
community-acquired
infections,
particularly
immunocompromised
individuals,
where
it
can
give
rise
to
pneumonia,
urinary
tract
septicemia,
liver
abscesses.
Treatment
K.
infections
compromised
by
emergence
producing
carbapenemase
extended-spectrum
β-lactamase
enzymes,
making
high
priority
for
new
therapeutic
approaches
including
vaccination
immunoprophylaxis.
One
potential
target
these
strategies
O-antigen
polysaccharide
component
lipopolysaccharides,
which
important
virulence
determinants
.
Consideration
immunotherapeutic
opportunities
requires
comprehensive
fundamental
understanding
O-polysaccharide
structures,
distribution
particular
O
serotypes
clinical
isolates,
antigenic
diversification.
The
number
recognized
antigens
has
varied
over
time,
complicated
observation
that
some
examples
share
similar
structural
(and
potentially
antigenically
cross-reactive)
elements,
existence
genetic
loci
corresponding
structures
have
yet
be
determined.
Here,
we
provide
integration
current
carbohydrate
information,
together
with
proposal
an
updated
classification
system
O-antigens,
being
implemented
Kaptive
molecular
serotyping.
accumulated
insight
into
assembly
pathways
used
describe
basis
diversity
SLAS DISCOVERY,
Год журнала:
2025,
Номер
unknown, С. 100232 - 100232
Опубликована: Апрель 1, 2025
Antimicrobial
resistance
(AMR)
develops
into
a
worldwide
health
emergency
through
genetic
and
biochemical
adaptations
which
enable
microorganisms
to
resist
antimicrobial
treatment.
β-lactamases
(blaNDM,
blaKPC)
efflux
pumps
(MexAB-OprM)
working
with
mobile
elements
facilitate
fast
proliferation
of
multidrug-resistant
(MDR)
exttreme
drug-resistant
(XDR)
phenotypes
thus
creating
major
concerns
for
healthcare
systems
community
as
well
the
agricultural
sector.
The
review
dissimilarly
unifies
molecular
pathways
public
implications
study
epidemiological
data
monitoring
approaches
innovative
therapeutic
solutions.
Previous
studies
separating
their
attention
between
genetics
clinical
outcomes
have
been
combined
our
approach
delivers
an
all-encompassing
analysis
AMR.
report
investigates
mechanisms
feature
enzymatic
degradation
pump
overexpression
together
target
modification
horizontal
gene
transfer
because
these
factors
represent
important
contributors
present-day
AMR
developments.
This
effects
on
hospital
environments
where
it
affects
pathogens
including
MRSA,
carbapenem-resistant
Klebsiella
pneumoniae,
Pseudomonas
aeruginosa.
document
explores
modern
management
methods
that
comprise
WHO
GLASS
surveillance
three
strategies
such
CRISPR-modified
genome
editing
bacteriophage
treatments
along
peptides
artificial
intelligence
diagnostic
tools.
resolution
needs
complete
scientific
global
operational
alongside
state-of-the-art
approaches.
Worldwide
infection
burden
requires
both
enhanced
prevention
procedures
next-generation
reduce
cases
effectively.
