Российский физиологический журнал им И М Сеченова,
Год журнала:
2024,
Номер
110(4), С. 527 - 546
Опубликована: Сен. 28, 2024
The
problem
of
modern
biomedicine
is
the
elucidation
multicomponent
and
multilevel
mechanism
a
single
neuroimmunoendocrine
regulation
physiological
functions,
which
plays
role
universal
conductor
all
life
processes.
Respiratory
diseases
lead
in
structure
general
morbidity
among
population
remain
one
most
pressing
problems
healthcare.
spread
lung
facilitated
by
lifestyle,
air
pollution,
smoking,
environment,
infections,
genetic
predisposition.
Various
risk
factors
can
contribute
to
development
pathologies
such
as
pneumonia,
cancer,
asthma,
chronic
obstructive
pulmonary
disease
others.
In
addition,
rates
these
tend
increase
every
year.
this
regard,
verification
study
signaling
molecules
involved
function
normal
pathological
conditions,
on
hand
be
considered
biomarkers
prognosis,
other
potential
targets
for
targeted
effective
therapy,
an
urgent
task
translational
biomedicine.
This
literature
review
devoted
key
participants
homeostasis
–
transcription
factor
NF-κB
respiratory
health
pathogenesis
diseases.
Summarizing
information
topic
extremely
important
promising
understanding
molecular
mechanisms
onset
course
diseases,
will
also
allow
us
develop
new
approaches
personalized
therapy
socially
significant
pathologies:
bronchial
acute
distress
syndrome
COVID-19.
A
detailed
activation
its
relationship
with
pathways
solving
main
innovative
methods
treatment
prevention
human
including
pathology
system.
Journal of Proteome Research,
Год журнала:
2024,
Номер
23(11), С. 5064 - 5084
Опубликована: Окт. 11, 2024
SARS-CoV-19
infection
provokes
a
variety
of
symptoms;
most
patients
present
mild/moderate
symptoms,
whereas
small
proportion
progress
to
severe
illness
with
multiorgan
failure
accompanied
by
metabolic
disturbances
requiring
ICU-level
care.
Given
the
importance
disease,
researchers
focused
on
identifying
severity-associated
biomarkers
in
infected
as
well
markers
associated
suffering
long-COVID.
However,
little
is
known
about
presence
that
remain
few
years
after
SARS-CoV-2
once
fully
recover
symptoms.
In
this
study,
we
evaluated
persistent
nasopharyngeal
tract
two
SARS-Cov-2
asymptomatic
patients,
taking
into
account
severity
their
(mild/moderate
and
infections).
addition
direct
identification
several
components
Coronavirus
Infection
Pathway
those
individuals
suffered
infections,
describe
herein
371
proteins
canonical
pathways
define
different
adverse
effects
infections.
The
persistence
these
for
up
infection,
along
ability
distinguish
endured,
highlights
surprising
exudate
changes
recovered
patients.
Viruses,
Год журнала:
2023,
Номер
15(11), С. 2229 - 2229
Опубликована: Ноя. 8, 2023
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
has
caused
a
global
pandemic
of
Disease
2019
(COVID-19).
Excessive
inflammation
is
hallmark
severe
COVID-19,
and
several
proteins
encoded
in
the
SARS-CoV-2
genome
are
capable
stimulating
inflammatory
pathways.
Among
these,
accessory
protein
open
reading
frame
3a
(ORF3a)
been
implicated
COVID-19
pathology.
Here
we
investigated
roles
ORF3a
binding
to
TNF
receptor-associated
factor
(TRAF)
inducing
nuclear
kappa
B
(NF-κB)
activation.
X-ray
crystallography
fluorescence
polarization
assay
revealed
low-affinity
between
an
N-terminal
peptide
TRAFs,
dual-luciferase
demonstrated
NF-κB
activation
by
ORF3a.
Nonetheless,
mutation
TRAF-binding
sequence
PIQAS
did
not
significantly
diminish
our
assay.
Our
results
thus
suggest
that
may
activate
through
alternative
mechanisms.
Российский физиологический журнал им И М Сеченова,
Год журнала:
2024,
Номер
110(4), С. 527 - 546
Опубликована: Сен. 28, 2024
The
problem
of
modern
biomedicine
is
the
elucidation
multicomponent
and
multilevel
mechanism
a
single
neuroimmunoendocrine
regulation
physiological
functions,
which
plays
role
universal
conductor
all
life
processes.
Respiratory
diseases
lead
in
structure
general
morbidity
among
population
remain
one
most
pressing
problems
healthcare.
spread
lung
facilitated
by
lifestyle,
air
pollution,
smoking,
environment,
infections,
genetic
predisposition.
Various
risk
factors
can
contribute
to
development
pathologies
such
as
pneumonia,
cancer,
asthma,
chronic
obstructive
pulmonary
disease
others.
In
addition,
rates
these
tend
increase
every
year.
this
regard,
verification
study
signaling
molecules
involved
function
normal
pathological
conditions,
on
hand
be
considered
biomarkers
prognosis,
other
potential
targets
for
targeted
effective
therapy,
an
urgent
task
translational
biomedicine.
This
literature
review
devoted
key
participants
homeostasis
–
transcription
factor
NF-κB
respiratory
health
pathogenesis
diseases.
Summarizing
information
topic
extremely
important
promising
understanding
molecular
mechanisms
onset
course
diseases,
will
also
allow
us
develop
new
approaches
personalized
therapy
socially
significant
pathologies:
bronchial
acute
distress
syndrome
COVID-19.
A
detailed
activation
its
relationship
with
pathways
solving
main
innovative
methods
treatment
prevention
human
including
pathology
system.
