Transcription Factor NF-κB: Role and Significance in the Neuroimmunoendocrine Regulation of Respiratory Function in Normal Conditions and in Lung Pathology DOI

Yu. I. Belova,

Ekaterina Mironova, T. S. Zubareva

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(4), P. 527 - 546

Published: Sept. 28, 2024

The problem of modern biomedicine is the elucidation multicomponent and multilevel mechanism a single neuroimmunoendocrine regulation physiological functions, which plays role universal conductor all life processes. Respiratory diseases lead in structure general morbidity among population remain one most pressing problems healthcare. spread lung facilitated by lifestyle, air pollution, smoking, environment, infections, genetic predisposition. Various risk factors can contribute to development pathologies such as pneumonia, cancer, asthma, chronic obstructive pulmonary disease others. In addition, rates these tend increase every year. this regard, verification study signaling molecules involved function normal pathological conditions, on hand be considered biomarkers prognosis, other potential targets for targeted effective therapy, an urgent task translational biomedicine. This literature review devoted key participants homeostasis – transcription factor NF-κB respiratory health pathogenesis diseases. Summarizing information topic extremely important promising understanding molecular mechanisms onset course diseases, will also allow us develop new approaches personalized therapy socially significant pathologies: bronchial acute distress syndrome COVID-19. A detailed activation its relationship with pathways solving main innovative methods treatment prevention human including pathology system.

Language: Английский

Longitudinal Assessment of Nasopharyngeal Biomarkers Post-COVID-19: Unveiling Persistent Markers and Severity Correlations DOI Creative Commons
Francisco Javier Redondo Calvo, Yoana Rabanal‐Ruiz,

Gema Verdugo-Moreno

et al.

Journal of Proteome Research, Journal Year: 2024, Volume and Issue: 23(11), P. 5064 - 5084

Published: Oct. 11, 2024

SARS-CoV-19 infection provokes a variety of symptoms; most patients present mild/moderate symptoms, whereas small proportion progress to severe illness with multiorgan failure accompanied by metabolic disturbances requiring ICU-level care. Given the importance disease, researchers focused on identifying severity-associated biomarkers in infected as well markers associated suffering long-COVID. However, little is known about presence that remain few years after SARS-CoV-2 once fully recover symptoms. In this study, we evaluated persistent nasopharyngeal tract two SARS-Cov-2 asymptomatic patients, taking into account severity their (mild/moderate and infections). addition direct identification several components Coronavirus Infection Pathway those individuals suffered infections, describe herein 371 proteins canonical pathways define different adverse effects infections. The persistence these for up infection, along ability distinguish endured, highlights surprising exudate changes recovered patients.

Language: Английский

Citations

1
SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence DOI Creative Commons
Brianna M. Busscher, Henock B. Befekadu, Liu Z

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(11), P. 2229 - 2229

Published: Nov. 8, 2023

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Disease 2019 (COVID-19). Excessive inflammation is hallmark severe COVID-19, and several proteins encoded in the SARS-CoV-2 genome are capable stimulating inflammatory pathways. Among these, accessory protein open reading frame 3a (ORF3a) been implicated COVID-19 pathology. Here we investigated roles ORF3a binding to TNF receptor-associated factor (TRAF) inducing nuclear kappa B (NF-κB) activation. X-ray crystallography fluorescence polarization assay revealed low-affinity between an N-terminal peptide TRAFs, dual-luciferase demonstrated NF-κB activation by ORF3a. Nonetheless, mutation TRAF-binding sequence PIQAS did not significantly diminish our assay. Our results thus suggest that may activate through alternative mechanisms.

Language: Английский

Citations

3
Role of Transcription Factor NF-κB in Neuroimmunoendocrine Mechanisms of Respiratory Diseases DOI

Yu. I. Belova,

Ekaterina Mironova, T. S. Zubareva

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(2), P. 802 - 817

Published: March 1, 2024

Language: Английский

Citations

0
Transcription Factor NF-κB: Role and Significance in the Neuroimmunoendocrine Regulation of Respiratory Function in Normal Conditions and in Lung Pathology DOI

Yu. I. Belova,

Ekaterina Mironova, T. S. Zubareva

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(4), P. 527 - 546

Published: Sept. 28, 2024

The problem of modern biomedicine is the elucidation multicomponent and multilevel mechanism a single neuroimmunoendocrine regulation physiological functions, which plays role universal conductor all life processes. Respiratory diseases lead in structure general morbidity among population remain one most pressing problems healthcare. spread lung facilitated by lifestyle, air pollution, smoking, environment, infections, genetic predisposition. Various risk factors can contribute to development pathologies such as pneumonia, cancer, asthma, chronic obstructive pulmonary disease others. In addition, rates these tend increase every year. this regard, verification study signaling molecules involved function normal pathological conditions, on hand be considered biomarkers prognosis, other potential targets for targeted effective therapy, an urgent task translational biomedicine. This literature review devoted key participants homeostasis – transcription factor NF-κB respiratory health pathogenesis diseases. Summarizing information topic extremely important promising understanding molecular mechanisms onset course diseases, will also allow us develop new approaches personalized therapy socially significant pathologies: bronchial acute distress syndrome COVID-19. A detailed activation its relationship with pathways solving main innovative methods treatment prevention human including pathology system.

Language: Английский

Citations

0