Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection DOI Creative Commons
Deepashri Rao,

Matthew Lewis,

Kimberly Meade‐White

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 17, 2024

Abstract The Crimean-Congo hemorrhagic fever virus (CCHFV) causes (CCHF), a widely distributed disease with significant morbidity and mortality. has high genetic diversity correlated geographic distribution, but limited temporal evolution within regions. Despite this, cases of CCHF region present as spectrum from often unrecognized asymptomatic infections to severe, fatal viral fever, suggesting host factors may play role in outcome. We investigated the effect on outcome CCHFV infection genetically diverse Collaborative Cross mouse model. Infected mice recapitulated full recognized humans similar human disease, replication, tissue pathology inflammatory responses were associated severity. Our study demonstrates that genetics contribute establishes resource model understand how contributes

Язык: Английский

Mapping of susceptibility loci for Ebola virus pathogenesis in mice DOI Creative Commons

Alexandra Schäfer,

Andrea Marzi,

Wakako Furuyama

и другие.

Cell Reports, Год журнала: 2024, Номер 43(5), С. 114127 - 114127

Опубликована: Апрель 21, 2024

Ebola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans. Host genetic variation plays critical role, yet the identity of host susceptibility loci mammals remains unknown. Using reference populations, we generate an F2 mapping cohort to identify that regulate EVD. While disease-resistant mice display minimal pathogenesis, susceptible severe liver pathology consistent with EVD-like and transcriptional signatures associated inflammatory metabolic processes. A significant quantitative trait locus (QTL) for RNA load blood is identified chromosome (chr)8, clinical mortality QTL mapped chr7, which includes Trim5 locus. knockout mice, validate as one potential driver failure after infection. The identification provides insight into molecular mechanisms regulating EVD progression severity, potentially informing therapeutics vaccination strategies.

Язык: Английский

Процитировано

6
Animal models of Long Covid: A hit-and-run disease DOI Open Access
Alexandra Schaefer, Sarah R. Leist, John M. Powers

и другие.

Science Translational Medicine, Год журнала: 2024, Номер 16(773)

Опубликована: Ноя. 13, 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because emergence variants that can cause disease 2019 (COVID-19) or enhance Long Covid phenotypes. About 5 to 10% SARS-CoV-2-infected individuals develop Covid, which, similar COVID 19, often affects lung. However, also affect other peripheral organs, especially brain. causal relationships between phenotypes, long-term symptoms, involvement multiple organ systems elusive, animal model mimicking both post-acute phases are imperative. Here, we review current state models, including possible future applications.

Язык: Английский

Процитировано

5
Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection DOI Creative Commons
Deepashri Rao,

Matthew Lewis,

Kimberly Meade-White

и другие.

npj Viruses, Год журнала: 2025, Номер 3(1)

Опубликована: Фев. 27, 2025

Abstract The Crimean-Congo hemorrhagic fever virus (CCHFV) causes (CCHF), a widely distributed disease with significant morbidity and mortality. has high genetic diversity correlated geographic distribution but limited temporal evolution within regions. Despite this, cases of CCHF region present as spectrum from often unrecognized asymptomatic infections to severe, fatal viral fever, suggesting host factors may play role in outcome. We investigated the effect on outcome CCHFV infection genetically diverse Collaborative cross (CC)-mouse model. Infected mice recapitulated full recognized humans, similar human disease, replication, tissue pathology, inflammatory responses were associated severity. Our study demonstrates that genetics contribute establishes CC mouse resource model understand how contributes

Язык: Английский

Процитировано

0
Sarbecovirus disease susceptibility is conserved across viral and host models DOI Creative Commons
Sarah R. Leist,

Alexandra Schäfer,

Ellen L Risemberg

и другие.

Virus Research, Год журнала: 2024, Номер 346, С. 199399 - 199399

Опубликована: Июнь 14, 2024

Coronaviruses have caused three severe epidemics since the start of 21

Язык: Английский

Процитировано

1
Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection DOI Creative Commons
Deepashri Rao,

Matthew Lewis,

Kimberly Meade‐White

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 17, 2024

Abstract The Crimean-Congo hemorrhagic fever virus (CCHFV) causes (CCHF), a widely distributed disease with significant morbidity and mortality. has high genetic diversity correlated geographic distribution, but limited temporal evolution within regions. Despite this, cases of CCHF region present as spectrum from often unrecognized asymptomatic infections to severe, fatal viral fever, suggesting host factors may play role in outcome. We investigated the effect on outcome CCHFV infection genetically diverse Collaborative Cross mouse model. Infected mice recapitulated full recognized humans similar human disease, replication, tissue pathology inflammatory responses were associated severity. Our study demonstrates that genetics contribute establishes resource model understand how contributes

Язык: Английский

Процитировано

0