Evidence-Based Approaches to Food Allergy Diagnosis DOI Creative Commons

Regina Capulong

Philippine journal of allergy, asthma and immunology, Год журнала: 2024, Номер 24(2)

Опубликована: Дек. 28, 2024

The prevalence of food allergy has increased in the past decades. However, most studies are based on self-reported clinical history rather than challenge-confirmed ones; these may overestimate allergy. Food been identified as one common causes anaphylaxis, especially among children. Like other studies, study by Rosero et al., published this issue, that is trigger for anaphylaxis pediatric patients admitted to a tertiary hospital.1 incidence food-induced children worldwide varied, with range 1 77 per 100,000 person‐years.2 Moreover, almost half all allergies experienced any previous reaction (46%, 2556/5587), Allergy Research & Education (FARE) Patient Registry.3 triggers causing adults crustaceans and eggs, cow’s milk, nuts, wheat, shellfish children.4,5 A detailed allergy-focused first step diagnostic work-up suspected have allergies. will serve guide tests be done. Skin prick (SPT) allergen extracts fresh food, serum-specific IgE (sIgE) individual components, basophil activation test (BAT) recommended support diagnosis IgE-mediated allergy.6 These high moderate sensitivity (negative result rules out FA) specificity (positive variety food.7 BAT suggested those an equivocal peanut sesame. gold standard diagnosing oral challenge (OFC). OFC resource-intensive pose severe allergic reactions. In EAACI guidelines FA, reference procedure confirm or exclude FA.6 Based same guidelines, double-blind placebo-controlled if open outcome indeterminate research studies. There available laboratories lack evidence validity do not show correlation Patients seek physicians' opinions regarding come clinic results marketed intolerance tests. Society practice parameters recommend unvalidated diagnose allergy.6,8-10 tests, such IgG IgG4 antibody level, hair analysis, electrodermal testing, antigen leukocyte test, mediator release kinesiology.11 Philippine Allergy, Asthma, Immunology does food-specific testing identify predict adverse reactions food.9 production normal immunologic response linked development tolerance, intolerance. Identifying through validated essential prevent future reactions, eliminate unnecessary elimination, nutritional deficiencies, improve quality life.

Язык: Английский

EAACI guidelines on the management of IgE‐mediated food allergy DOI Creative Commons
Alexandra F. Santos, Carmen Riggioni, Ioana Agache

и другие.

Allergy, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

This European Academy of Allergy and Clinical Immunology (EAACI) guideline provides recommendations for the management IgE-mediated food allergy was developed using Grading Recommendations, Assessment, Development Evaluations (GRADE) approach. Following confirmation diagnosis, allergen avoidance dietary advice (with support a specialised dietitian, if possible) together with provision written treatment plan, education on recognition allergic symptoms prescription medication including adrenaline an auto-injector are essential. Patients significant anxiety requirement coping strategies may benefit from clinical psychologist. As immunomodulatory interventions, omalizumab is suggested in children age 1 adults; oral allergen-specific immunotherapy recommended adolescents peanut milk egg allergies (generally after 4 years egg). Sublingual epicutaneous but not yet available at point care. Future research into disease modifying treatments highly needed, standardised patient-focused protocols outcomes.

Язык: Английский

Процитировано

9
The mental health burden of food allergies: Insights from patients and their caregivers from the Food Allergy Research & Education (FARE) Patient Registry DOI Creative Commons
Thomas B. Casale, Christopher Warren, Sachin Gupta

и другие.

World Allergy Organization Journal, Год журнала: 2024, Номер 17(4), С. 100891 - 100891

Опубликована: Март 23, 2024

Food allergies impose a large psychosocial burden, including mental, emotional, and social aspects, on both patients their caregivers. Patients, caregivers, families often experience anxiety, isolation, fear around food allergies. To assess the real-world mental health burden of allergies, using Allergy Research & Education (FARE) Patient Registry (NCT04653324). Self-reported data from with were analyzed FARE History Mental Health Concerns surveys. Odds ratios also calculated as measure association between patient allergy characteristics likelihood having concerns or formal diagnosis. The included 1680 patients/caregivers. Anxiety (54%) panic (32%) most common emotions that reported result eating produced an allergic reaction. About two-thirds related to (62%), anxiety after reaction, about living avoidance. Caregivers experienced for safety children, sought care cope worry caring allergy-related was increased experiencing more than 1 reaction per year (OR 1.68-1.90) lowered diagnosis 0.43). filling out survey pediatric 4.03) 2.36) significant predictors Our study highlights continuing unmet need screening support part management

Язык: Английский

Процитировано

5
Contribution of T cell subsets to different food allergic diseases DOI Creative Commons
Lisa Hung,

Brianna Zientara,

M. Cecilia Berin

и другие.

Immunological Reviews, Год журнала: 2024, Номер 326(1), С. 35 - 47

Опубликована: Июль 25, 2024

Food allergies occur due to a lack of tolerance the proteins found in foods. While IgE- and non-IgE-mediated food have different clinical manifestations, epidemiology, pathophysiology, management, they share dysregulated T cell responses. Recent studies shed light on contributions subsets development persistence allergic diseases. This review discusses role cells both considers potential future investigations this context.

Язык: Английский

Процитировано

4
Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life DOI Creative Commons
Haoran Gao,

Allison E Kosins,

Joel A Ochoa

и другие.

The Journal of Immunology, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Food allergy can be life threatening and often develops early in life, especially infants children with atopic dermatitis. is induced neonatal mice skin barrier mutations (Flaky Tail, FT+/- filaggrin mattrin gene mutations) by epicutaneous sensitization co-exposures to the food allergen peanut extract (PNE), environmental Alternaria alternata (Alt), detergent (4% SDS); oral PNE-challenge induces anaphylaxis. Sensitization these neonates also eosinophil infiltration into elevates expression of eotaxins (CCL11 CCL24). However, roles for eosinophils are not known. In this study, iPhil+/- pups, which have an inducible eosinophil-deficiency upon injection diphtheria toxin (DTX), were sensitized then received PNE gavage assess DTX depletion eosinophils, during PNE-challenge, blocked recruitment activation mast cells, Alt+PNE-induced increase plasma IL-33 OSM, attenuated serum PNE-specific IgE/IgG1/IgG2b, oral-PNE-induced Anti-IL-5 sensitization/challenge When depleted allergen-skin-sensitization restored before anaphylaxis was blocked. contrast, when present but Together, data indicate that although necessary allergen-induced anaphylaxis, a critical role development regulating sensitization-induced cell numbers allergen-specific IgE.

Язык: Английский

Процитировано

0
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-allergic Children with Atopic Comorbidities DOI
Amy M. Scurlock, David M. Fleischer, George Du Toit

и другие.

Annals of Allergy Asthma & Immunology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Hospitalizations for food-induced anaphylaxis in Spain (2016-2021): A population-based epidemiologic study (Preprint) DOI Creative Commons
Rodrigo Jiménez‐García, Ana López‐de‐Andrés, Valentín Hernández‐Barrera

и другие.

JMIR Public Health and Surveillance, Год журнала: 2024, Номер 10, С. e57340 - e57340

Опубликована: Авг. 27, 2024

Background Food-induced anaphylaxis (FIA) is a major public health problem resulting in serious clinical complications, emergency department visits, hospitalization, and death. Objective This study aims to assess the epidemiology trends hospitalizations because of FIA Spain between 2016 2021. Methods An observational descriptive was conducted using data from Spanish National Hospital discharge database. Information coded based on International Classification Diseases, Tenth Revision. The population analyzed by gender age group according food triggers, characteristics, admission intensive care unit, severity, in-hospital mortality. annual incidence per 100,000 person-years estimated Poisson regression models. Multivariable logistic models were constructed identify which variables associated with severe FIA. Results A total 2161 hospital admissions for recorded overall rate 0.77 cases person-years. highest found those aged <15 years (3.68), lower figures among 15 59 (0.25) ≥60 (0.29). showed significant increase 2021 only children (3.78 vs 5.02 person-years; P=.04). most frequent triggers “milk dairy products” (419/2161, 19.39% cases) “peanuts or tree nuts seeds” (409/2161, 18.93%). Of patients, 256 (11.85%) hospitalized required 11 (0.51%) patients died hospital. Among children, appeared 0 4 (40/99, 40%). adults, 69.4% (111/160) occurred years. be (odds ratio 5.1, 95% CI 3.11-8.36), 3.87, 1.99-7.53), asthma 1.71,95% 1.12-2.58). Conclusions In Spain, hospitalization increased slightly, although (P=.04) children. Even if mortality remains low stable, proportion high has not improved 2021, older being risk factors severity. Surveillance must improved, preventive strategies implemented reduce burden

Язык: Английский

Процитировано

1
Food Allergy Yardstick: Where Does Omalizumab Fit? DOI
Aikaterini Anagnostou, Matthew Greenhawt,

Marcus Shaker

и другие.

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

0
The Efficacy and Safety of Stepwise Oral Food Challenge in Children with Cow’s Milk Allergy DOI
Mika Ogata, Jun Kido,

S. Watanabe

и другие.

International Archives of Allergy and Immunology, Год журнала: 2024, Номер unknown, С. 1 - 11

Опубликована: Окт. 17, 2024

Stepwise oral food challenge (OFC) tests begin with low doses of allergens and progress to full doses. We previously reported the safety efficacy stepwise OFC for reintroducing hen eggs. In this study, we discuss its application cow's milk (CM) allergy.

Язык: Английский

Процитировано

0
SAÚDE MENTAL: CRISES ALÉRGICAS EMOCIONAIS DOI Creative Commons
Karine Silva, Viviane Marinho dos Santos

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Год журнала: 2024, Номер 5(11), С. e5115950 - e5115950

Опубликована: Ноя. 16, 2024

O estudo explora a conexão entre alergias, fatores emocionais e bem-estar mental, tratando da crescente inquietação em relação às doenças alérgicas como uma questão de saúde pública mundial. A urbanização contaminação ambiental desempenham um papel nesse aumento, enquanto o estresse, seja ele temporário ou prolongado, é reconhecido elemento que pode agravar resposta alérgica. psicodermatologia, disciplina une dermatologia à psicologia, ressalta as questões afetam condições pele qualidade vida dos indivíduos. abordagem deste consiste revisão integrativa literatura, examina publicações recentes relacionadas alergias aspectos emocionais, foram adotados alguns critérios inclusão exclusão. As descobertas sugerem estresse vivenciado pelas mães, especialmente durante gestação, está ligado maior surgimento seus filhos. Ademais, indivíduos sofrem costumam lidar com carga emocional significativa, impacta negativamente sua mental vida. destaca importância estratégia integrada no tratamento abrange diversas áreas, dermatologia, psicologia imunologia. Recomenda-se adoção terapias levem conta tanto os físicos quanto incluindo práticas gerenciamento emocional, para auxiliar pacientes enfrentarem causado crises alérgicas. Essa metodologia aprimorar eficácia do tratamento, ao considerar alergias.

Процитировано

0
Management and disease burden of children and adults with severe IgE-mediated food allergy: Are adults the lost population? DOI Creative Commons
Katharina Blümchen, Martin Hutter,

Sabine Schnadt

и другие.

World Allergy Organization Journal, Год журнала: 2024, Номер 17(12), С. 100971 - 100971

Опубликована: Ноя. 21, 2024

Язык: Английский

Процитировано

0