Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

Biomedicines, Год журнала: 2023, Номер 11(2), С. 294 - 294

Опубликована: Янв. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Язык: Английский

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The gut–airway microbiome axis in health and respiratory diseases

Nature Reviews Microbiology, Год журнала: 2024, Номер 22(8), С. 492 - 506

Опубликована: Май 22, 2024

Язык: Английский

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Targeting Bacterial Persisters via Reactive Oxygen Species‐Generating Hydrogel Microspheres

Advanced Functional Materials, Год журнала: 2024, Номер 34(46)

Опубликована: Июнь 19, 2024

Abstract The presence of bacterial persisters is a key factor contributing to chronic infection. However, no effective treatment methods are currently available. Thus, platform developed, called reactive oxygen species (ROS) bomb, based on microenvironment‐adaptive hydrogel microspheres, oxidize the cell membranes in periprosthetic joint infection (PJI). Fenton reagent hydroxy iron oxide (FeOOH) and glucose oxidase (GOx)/calcium phosphate (CaP) acid‐responsive shell sequentially induced surface mesoporous polydopamine (PDA) nanoparticles by PDA‐mediated ion precipitation interfacial adhesion, followed coloaded with into microfluidic hyaluronic acid microspheres. Hydroxyl radicals explosively generated through GOx‐mediated oxidase, H 2 O production, its Fenton‐like reactions FeOOH, which also benefit from weakly acidic microenvironment around persisters, result destruction membrane, subsequent overflow cellular contents such as dsDNA, proteins, K + . bactericidal rates methicillin‐resistant Staphylococcus aureus epidermidis up 99.14% 98.96%, loads lesion location significantly decreased after ROS bombs treated, effectively alleviated inflammation bone resorption damage. This work provides new strategy toward clearance shows great application potential other infection‐related diseases.

Язык: Английский

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The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract

Physiological Reviews, Год журнала: 2023, Номер 104(2), С. 835 - 879

Опубликована: Дек. 7, 2023

The last decade of microbiome research has highlighted its fundamental role in systemic immune and metabolic homeostasis. plays a prominent during gestation into early life, when maternal lifestyle factors shape development the newborn. Breast milk further shapes gut colonization, supporting tolerance to commensal bacteria harmless antigens while preventing outgrowth pathogens. Environmental microbial that disrupt this process can dysregulate homeostasis, predisposing infants atopic disease childhood asthma. In health, low-biomass lung microbiome, together with inhaled environmental constituents, establishes immunological set point is necessary maintain pulmonary defense. However, perturbations physiological processes allow upper respiratory tract act as reservoir pathogenic bacteria, which colonize diseased cause severe inflammation. Studying these host-microbe interactions diseases holds great promise stratify patients for suitable treatment regimens biomarker discovery predict progression. Preclinical studies show microbes are constant flux cell division death, releasing by-products, vesicles system protect against diseases. next major advances may come from testing utilizing clinical benefit exploiting predictive power by employing multiomics analysis approaches.

Язык: Английский

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Early-life exposures and the microbiome: implications for IBD prevention

Gut, Год журнала: 2023, Номер unknown, С. gutjnl - 330002

Опубликована: Дек. 12, 2023

The early-life period is one of microbiome establishment and immune maturation. Early-life exposures are increasingly being recognised to play an important role in IBD risk. composition functions the gut prenatal, perinatal, postnatal may be crucial towards development health or disease, including IBD, later life. We herein present a comprehensive summary interplay between factors perturbations, their association with risk IBD. In addition, we provide overview host external early life that known impact maturation implicated Considering emerging concept prevention, propose strategies minimise maternal offspring exposure potentially harmful variables recommend protective measures during pregnancy postpartum period. This holistic view signatures among mothers will help frame our current understanding importance pathogenesis roadmap for preventive strategies.

Язык: Английский

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Interactions between microbiome and underlying mechanisms in asthma

Respiratory Medicine, Год журнала: 2023, Номер 208, С. 107118 - 107118

Опубликована: Янв. 11, 2023

Язык: Английский

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Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease

Annals of Medicine, Год журнала: 2024, Номер 56(1)

Опубликована: Апрель 22, 2024

Introduction A large proportion of patients with inflammatory bowel disease (IBD) experience IBD-related conditions outside the gastrointestinal tract, termed extraintestinal manifestations (EIMs) which further decreases quality life and, in extreme cases, can be threatening. The pathogenesis EIMs remains unknown, and although gut microbiota alterations are a well-known characteristic IBD, its relationship sparsely investigated. This study aimed to compare IBD without EIMs.

Язык: Английский

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Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2024, Номер 12(7), С. 1686 - 1694

Опубликована: Апрель 25, 2024

Язык: Английский

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Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders

Biomedicines, Год журнала: 2025, Номер 13(1), С. 121 - 121

Опубликована: Янв. 7, 2025

Introduction: The shaping of the human intestinal microbiota starts during intrauterine period and continues through subsequent stages extrauterine life. plays a significant role in predisposition development immune diseases, as well various inflammatory processes. Importantly, proper colonization fetal digestive system is influenced by maternal microbiota, method pregnancy completion further formation microbiota. In child's life, breastfeeding, diet use antibiotics influence state eubiosis, which determines growth from neonatal to adulthood. literature data suggest that there evidence confirm infant an important regulating response associated with allergic diseases. However, identification specific bacterial species relation types reactions diseases basic problem. Background: main aim review was demonstrate mother, fetus newborn on functioning context allergies asthma. Methods: We reviewed thoroughly analyzed content over 1000 articles abstracts between beginning June end August 2024. Over 150 were selected for detailed study. Results: selection based PubMed National Library Medicine search engine, using keywords: "the impact asthma", "intestinal diseases", "intrauterine atopic dermatitis", food allergies", "maternal microbiota", "fetal microbiota" "neonatal microbiota". above relationships constituted criteria including analysis. Conclusions: present review, we showed relationship normal system. eubiosis adequate amount diversity essential preventing way shaped, resulting health-promoting behavior pregnant women, rational conduct medical staff performance diagnostic therapeutic process, necessary maintain health mother child. Therefore, appropriate lifestyle, antibiotic therapy completing are indispensable prevention conditions. At same time, considering genera phyla bacteria have potentially protective effect, it worth noting suitable probiotics prebiotics seems contribute effect.

Язык: Английский

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Maternal Vaginal and Fecal Microbiota in Later Pregnancy Contribute to Child Fecal Microbiota Development in the ECHO Cohort

iScience, Год журнала: 2025, Номер 28(4), С. 112211 - 112211

Опубликована: Март 13, 2025

There is growing interest in the use of microbial-seeding interventions to mitigate impacts prenatal antibiotics, C-section, and lack breastfeeding on mother-child microbe sharing. However, relative importance maternal vaginal vs. fecal microbiota this process unclear. Analyzing 16S rRNA sequences from five US birth cohorts, we found that became more similar as pregnancy progressed, both niches influenced child's microbiota. The contribution increased when sampling occurred later gestation. As children aged 5 years, their increasingly resembled mother's compared Patterns sharing appeared differ by antibiotic use, mode (C-section vaginal), breastfeeding. Our findings enhance understanding niche-specific may inform interventions. Metagenomic studies are needed identify specific shared strains.

Язык: Английский

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