Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 15, 2024
Aim
and
background
Tertiary
lymphoid
structures
(TLS)
are
increasingly
recognized
for
their
role
in
immunity.
Despite
growing
interest,
a
systematic
bibliometric
analysis
of
TLS-related
research
has
been
lacking.
To
provide
comprehensive
overview
current
trends
hotspots,
we
conducted
using
data
from
the
Web
Science
Core
Collection.
Methods
We
retrieved
publications
Citation
Index
Expanded
within
Collection
January
2014
to
December
2023.
Co-occurrence
with
“VOSviewer”
identified
status
while
“CiteSpace”
was
used
co-citation
assess
knowledge
evolution
bursts.
Thematic
explored
bibliometrics
identify
emerging
keyword
trends.
Additionally,
examined
country/region,
institutional,
author
contributions
collaborations.
Tables
were
created
Microsoft
Word.
Results
A
total
785
analyzed,
showing
continuous
growth
trend
2017
2023,
indicating
escalating
interest
TLS
among
researchers.
Leading
countries
China
(231
publications),
United
States
(212
France
(89
publications).
The
most
productive
institution
“Institut
national
de
la
santé
et
recherche
médicale”
(70
publications)
Catherine
Sautes-Fridman
(21
respectively.
Key
topics
included
TLS,
B
cells,
immunotherapy.
Recent
focused
on
mechanisms
linking
cancers,
such
as
immunotherapy,
tumor
microenvironment,
tumor-infiltrating
lymphocytes,
prognosis,
immune
checkpoint
inhibitors,
highlighting
an
expanding
area
study.
TLS’
potential
biomarker
predicting
immunotherapy
efficacy
across
different
cancer
types
remains
burgeoning
direction.
Conclusions
This
study
provides
global
publications,
revealing
key
literature
metrics
identifying
influential
articles
concerns.
These
findings
contribute
valuable
insights
into
suggest
future
directions
this
dynamic
field.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 28, 2024
Tertiary
lymphoid
structures
(TLSs)
are
defined
as
aggregates
formed
in
non-hematopoietic
organs
under
pathological
conditions.
Similar
to
secondary
(SLOs),
the
formation
of
TLSs
relies
on
interaction
between
tissue
inducer
(LTi)
cells
and
organizer
(LTo)
cells,
involving
multiple
cytokines.
Heterogeneity
is
a
distinguishing
feature
TLSs,
which
may
lead
differences
their
functions.
Growing
evidence
suggests
that
associated
with
various
diseases,
such
cancers,
autoimmune
transplant
rejection,
chronic
inflammation,
infection,
even
ageing.
However,
detailed
mechanisms
behind
these
clinical
associations
not
yet
fully
understood.
The
by
TLS
maturation
localization
affect
immune
function
also
unclear.
Therefore,
it
necessary
enhance
understanding
development
at
cellular
molecular
level,
allow
us
utilize
them
improve
microenvironment.
In
this
review,
we
delve
into
composition,
mechanism,
potential
therapeutic
applications
TLSs.
Furthermore,
discuss
implications
role
markers
response
prognosis.
Finally,
summarize
methods
for
detecting
targeting
Overall,
provide
comprehensive
aim
develop
more
effective
strategies.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Gastric
cancer
is
a
common
malignant
tumor
of
the
digestive
tract,
and
its
treatment
remains
significant
challenge.
In
recent
years,
role
various
immune
cells
in
microenvironment
progression
has
gained
increasing
attention.
Immunotherapy,
primarily
based
on
checkpoint
inhibitors,
notably
improved
prognosis
patients
with
gastric
cancer;
however,
challenges
regarding
therapeutic
efficacy
persist.
Histological
features
within
microenvironment,
such
as
tertiary
lymphoid
structures
(TLSs),
tumor-infiltrating
lymphocytes,
proportion
intratumoral
stroma,
are
emerging
potentially
effective
prognostic
factors.
cancer,
TLSs
may
serve
local
hubs,
enhancing
ability
to
interact
recognize
antigens,
which
closely
linked
effectiveness
immunotherapy
survival
rates
patients.
However,
specific
cell
type
driving
TLS
formation
tumors
not
yet
been
elucidated.
Mature
B-cell
regions
containing
germinal
centers.
During
center
formation,
B
undergo
transformations
become
mature
function,
exerting
anti-tumor
effects.
Therefore,
targeting
could
provide
new
avenues
for
immunotherapy.
This
review,
combined
current
research
elaborates
relationship
between
aiming
guidance
precise
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 4, 2024
Tertiary
lymphoid
structures
(TLS)
represent
the
ectopic
aggregations
of
immune
cells
arising
during
chronic
inflammation
or
tumor
progression.
In
cancer,
TLS
are
often
associated
with
beneficial
clinical
outcomes
in
patients
undergoing
immunotherapy,
underscoring
their
prognostic
and
predictive
significance.
Mature
TLS,
characterized
by
germinal
centers
areas
T-cell
B-cell
aggregation,
considered
primary
locations
for
activating
maintaining
both
humoral
cellular
anti-tumor
effects.
Despite
recognized
importance,
mechanisms
driving
formation
mature
cancer
influence
on
response
within
tumors
remain
insufficiently
understood.
Therefore,
this
review
aims
to
comprehensively
explore
structural
composition,
development
mechanisms,
maturity
impact
factors,
immunological
function,
innovative
therapeutic
strategies
microenvironment.
The
research
summarized
herein
offers
novel
insights
considerations
approaches
promote
generation
maturation
representing
a
promising
avenue
future
therapies.
