Flexible and stretchable bioelectronics for organoids
Med-X,
Год журнала:
2025,
Номер
3(1)
Опубликована: Фев. 1, 2025
Abstract
Organoids
have
gained
significant
interest
due
to
their
ability
recapitulate
the
structural,
molecular,
and
functional
complexity
of
corresponding
organs.
While
methods
been
developed
characterize
benchmark
organoid
structural
molecular
properties,
capturing
development
maturation
organoids
remains
challenging.
To
address
this,
multifunctional
bioelectronics
for
interfacing
with
has
actively
pursued.
However,
conventional
electronics
face
limitations
in
achieving
recording
control
across
entire
three-dimensional
(3D)
volume
a
long-term
stable
manner
large
morphological
cellular
composition
changes
during
development.
In
this
review,
we
first
discuss
application
interfacing.
We
then
focus
on
flexible
stretchable
designed
create
organoid/electronics
hybrids
chronically
interfaces.
also
review
recent
advancements
charting
multimodal
cell
activities
throughout
Furthermore,
explore
integration
other
characterization
modalities
comprehensive
cells
within
3D
tissues.
Finally,
potential
integrating
artificial
intelligence
into
system
through
embedded
electronics,
harnessing
biosymbiotic
computational
systems.
These
could
provide
valuable
tools
characterizing
maturation,
establishing
patient-specific
models,
developing
therapeutic
opportunities,
exploring
novel
strategies.
Graphical
abstract
Язык: Английский
An ingestible bioimpedance sensing device for wireless monitoring of epithelial barriers
Microsystems & Nanoengineering,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 7, 2025
Abstract
Existing
gastrointestinal
(GI)
diagnostic
tools
are
unable
to
non-invasively
monitor
mucosal
tight
junction
integrity
in
vivo
beyond
the
esophagus.
In
GI
tract,
local
inflammatory
processes
induce
alterations
proteins,
enhancing
paracellular
ion
permeability.
Although
transepithelial
electrical
resistance
(TEER)
may
be
used
laboratory
assess
barrier
integrity,
there
no
existing
methodologies
for
characterizing
dilation
vivo.
Addressing
this
technology
gap,
intraluminal
bioimpedance
sensing
employed
as
a
localized,
non-invasive
surrogate
TEER
electrodes
cell
cultures.
Thus
far,
has
only
been
implemented
esophagogastroduodenoscopy
(EGD)
due
need
external
electronics
connections.
work,
we
develop
novel,
noise-resilient
Bluetooth-enabled
ingestible
device
continuous,
measurement
of
intestinal
“leakiness.”
As
proof-of-concept,
validate
wireless
impedance
readout
on
excised
porcine
tissues
motion.
Through
an
animal
study,
demonstrate
how
exhibits
altered
response
induced
mice
colonic
tissue
through
calcium-chelator
exposure.
Device
measurements
validated
using
standard
benchtop
methods
assessing
Язык: Английский
Quantifying insertional effects in deep brain stimulation: clinical outcomes and neurophysiological mechanisms
Expert Review of Medical Devices,
Год журнала:
2025,
Номер
unknown, С. 1 - 7
Опубликована: Март 17, 2025
Introduction
Deep
brain
stimulation
(DBS)
has
revolutionized
the
treatment
of
various
neurological
and
psychiatric
disorders.
However,
recent
findings
highlight
significant
clinical
molecular
responses
elicited
by
mere
insertion
DBS
electrodes,
termed
'insertional
effects.'
This
review
explores
manifestations
underlying
mechanisms
these
effects,
emphasizing
their
implications
for
neuromodulation
therapies.
Язык: Английский
Soft, stretchable conductive hydrogels for high-performance electronic implants
Science Advances,
Год журнала:
2025,
Номер
11(12)
Опубликована: Март 21, 2025
Conductive
hydrogels
are
emerging
as
promising
materials
for
electronic
implants
owing
to
their
favorable
mechanical
and
electrical
properties.
Poly(3,4-ethylenedioxythiophene):poly(styrene
sulfonate)
(PEDOT:PSS)
particularly
attractive,
but
preparation
often
requires
toxic
additives.
Here,
we
introduced
a
nutritive
sweetener,
d
-sorbitol,
nontoxic
additive
create
soft
stretchable
PEDOT:PSS
conductive
hydrogels.
These
exhibit
properties
comparable
with
biological
tissues,
reducing
adverse
immune
responses.
The
can
be
patterned
on
elastic
substrates
using
simple,
low-cost
micromolding
technique
fabricate
implantable
devices
stimulation
recording.
hydrogel
electrodes
show
much
lower
electrochemical
impedance
higher
charge
storage
injection
capacity
compared
platinum
electrodes.
In
addition,
the
of
remain
stable
after
long-term
exposure
extreme
conditions.
We
demonstrate
use
hydrogel-based
effective
high-quality
recordings
in
live
animal
models.
Язык: Английский
Photovoltaic bioelectronics merging biology with new generation semiconductors and light in biophotovoltaics photobiomodulation and biosensing
Deleted Journal,
Год журнала:
2024,
Номер
1(1)
Опубликована: Ноя. 21, 2024
Abstract
This
review
covers
advancements
in
biosensing,
biophotovoltaics,
and
photobiomodulation,
focusing
on
the
synergistic
use
of
light,
biomaterials,
cells
or
tissues,
interfaced
with
photosensitive
dye-sensitized,
perovskite,
conjugated
polymer
organic
semiconductors
nanoparticles.
Integration
semiconductor
biological
systems,
using
non-invasive
light-probes
-stimuli
for
both
sensing
controlling
behavior,
has
led
to
groundbreaking
applications
like
artificial
retinas.
From
fusion
photovoltaics
biology,
a
new
research
field
emerges:
photovoltaic
bioelectronics.
Язык: Английский
Soft Implantable Bioelectronics for the Management of Neurological Disorders and Cardiovascular Diseases
Korean Journal of Chemical Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Язык: Английский
Unlocking High-Efficiency Energy Storage and Conversion with Biocompatible Electrodes: The Key Role of Interfacial Interaction Assembly and Structural Design
Energy Advances,
Год журнала:
2024,
Номер
3(9), С. 2152 - 2174
Опубликована: Янв. 1, 2024
This
perspective
paper
covers
textile-
and
hydrogel-based
biocompatible
electrodes,
their
applications
for
supercapacitors,
biofuel
cells,
actuators,
focusing
on
the
importance
of
interfacial
interactions
between
electrode
components.
Язык: Английский
Wirefree electrochemistry for enhanced detection and treatment of disease
Electrochemistry Communications,
Год журнала:
2024,
Номер
169, С. 107832 - 107832
Опубликована: Ноя. 2, 2024
Язык: Английский
Soft Cardiac Patch Using a Bifacial Architecture of Adhesive/Low‐Impedance Hydrogel Nanocomposites and Highly Conductive Elastomer Nanocomposites
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Soft
implantable
multichannel
cardiac
electrode
arrays
that
establish
direct
monolithic
interfaces
with
the
heart
are
key
components
for
advanced
monitoring
and
electrical
modulation.
A
significant
technological
advancement
in
this
area
is
development
of
stretchable
conductive
nanocomposites,
fabricated
through
integration
metallic
nanomaterials
elastic
polymers,
aimed
at
achieving
both
high
conductivity
mechanical
elasticity.
Despite
these
advances,
further
progress
material
performance
device
designs
required
to
ensure
seamless,
reliable,
biocompatible,
high‐fidelity
interfacing.
Herein,
a
soft
patch
based
on
bifacial
architecture
adhesive/low‐impedance
hydrogel
nanocomposites
highly
elastomer
reported.
The
design
facilitates
between
other
tissues/organs
can
be
achieved.
nanocomposite
layer,
positioned
epicardial
side,
provides
stable
adhesion
target
tissue
enables
low‐impedance
biocompatible
interfacing
heart,
while
opposite
offers
facile
electrophysiological
signal
transfer
low‐friction
surface
minimizing
unwanted
interactions
surrounding
tissues.
effectiveness
multiple
applications
involving
various
recordings
electromechanical
modulation
demonstrations
showcased.
Язык: Английский
Tapping into tissue bioelectromechanics: Electroactive biopolymers for dynamic tissue engineering
APL Materials,
Год журнала:
2024,
Номер
12(12)
Опубликована: Дек. 1, 2024
The
success
of
tissue
engineering
constructs
in
restoring
healthy
function
is
driven
by
the
interplay
cells
with
their
microenvironmental
cues.
Therefore,
design
materials
typically
guided
ensuring
adequate
mimicry
and
regulation
dynamic
biochemical,
mechanical,
electrical
interactions
that
occur
cellular
extracellular
milieu.
In
this
work,
we
introduce
current
approaches
limitations
to
static
stimuli-responsive
engineering,
a
focus
on
electroactive
materials.
We
consider
mechanisms
material
development
polymers
for
soft
robotics
address
how
these
developments
can
pave
way
‘smart’
devices
recapitulate
key
elements
bioelectromechanics.
By
highlighting
successes
challenges
support
such
devices,
summarize
our
findings
guidelines
direct
future
clinically
translatable
efficacious
functionality
robots.
Язык: Английский