Tapping into tissue bioelectromechanics: Electroactive biopolymers for dynamic tissue engineering DOI Creative Commons

May Ayres Burgess,

Malavika Nair

APL Materials, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

The success of tissue engineering constructs in restoring healthy function is driven by the interplay cells with their microenvironmental cues. Therefore, design materials typically guided ensuring adequate mimicry and regulation dynamic biochemical, mechanical, electrical interactions that occur cellular extracellular milieu. In this work, we introduce current approaches limitations to static stimuli-responsive engineering, a focus on electroactive materials. We consider mechanisms material development polymers for soft robotics address how these developments can pave way ‘smart’ devices recapitulate key elements bioelectromechanics. By highlighting successes challenges support such devices, summarize our findings guidelines direct future clinically translatable efficacious functionality robots.

Language: Английский

Flexible and stretchable bioelectronics for organoids DOI Creative Commons

Jaeyong Lee,

Jia Liu

Med-X, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 1, 2025

Abstract Organoids have gained significant interest due to their ability recapitulate the structural, molecular, and functional complexity of corresponding organs. While methods been developed characterize benchmark organoid structural molecular properties, capturing development maturation organoids remains challenging. To address this, multifunctional bioelectronics for interfacing with has actively pursued. However, conventional electronics face limitations in achieving recording control across entire three-dimensional (3D) volume a long-term stable manner large morphological cellular composition changes during development. In this review, we first discuss application interfacing. We then focus on flexible stretchable designed create organoid/electronics hybrids chronically interfaces. also review recent advancements charting multimodal cell activities throughout Furthermore, explore integration other characterization modalities comprehensive cells within 3D tissues. Finally, potential integrating artificial intelligence into system through embedded electronics, harnessing biosymbiotic computational systems. These could provide valuable tools characterizing maturation, establishing patient-specific models, developing therapeutic opportunities, exploring novel strategies. Graphical abstract

Language: Английский

Citations

0
An ingestible bioimpedance sensing device for wireless monitoring of epithelial barriers DOI Creative Commons

Bill Holt,

Justin M. Stine, Luke A. Beardslee

et al.

Microsystems & Nanoengineering, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 7, 2025

Abstract Existing gastrointestinal (GI) diagnostic tools are unable to non-invasively monitor mucosal tight junction integrity in vivo beyond the esophagus. In GI tract, local inflammatory processes induce alterations proteins, enhancing paracellular ion permeability. Although transepithelial electrical resistance (TEER) may be used laboratory assess barrier integrity, there no existing methodologies for characterizing dilation vivo. Addressing this technology gap, intraluminal bioimpedance sensing employed as a localized, non-invasive surrogate TEER electrodes cell cultures. Thus far, has only been implemented esophagogastroduodenoscopy (EGD) due need external electronics connections. work, we develop novel, noise-resilient Bluetooth-enabled ingestible device continuous, measurement of intestinal “leakiness.” As proof-of-concept, validate wireless impedance readout on excised porcine tissues motion. Through an animal study, demonstrate how exhibits altered response induced mice colonic tissue through calcium-chelator exposure. Device measurements validated using standard benchtop methods assessing

Language: Английский

Citations

0
Quantifying insertional effects in deep brain stimulation: clinical outcomes and neurophysiological mechanisms DOI Creative Commons
Aaron Lawson McLean, Jakob Nemir

Expert Review of Medical Devices, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: March 17, 2025

Introduction Deep brain stimulation (DBS) has revolutionized the treatment of various neurological and psychiatric disorders. However, recent findings highlight significant clinical molecular responses elicited by mere insertion DBS electrodes, termed 'insertional effects.' This review explores manifestations underlying mechanisms these effects, emphasizing their implications for neuromodulation therapies.

Language: Английский

Citations

0
Soft, stretchable conductive hydrogels for high-performance electronic implants DOI Creative Commons
Md. Saifur Rahman, Ahnsei Shon,

Rose Joseph

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(12)

Published: March 21, 2025

Conductive hydrogels are emerging as promising materials for electronic implants owing to their favorable mechanical and electrical properties. Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) particularly attractive, but preparation often requires toxic additives. Here, we introduced a nutritive sweetener, d -sorbitol, nontoxic additive create soft stretchable PEDOT:PSS conductive hydrogels. These exhibit properties comparable with biological tissues, reducing adverse immune responses. The can be patterned on elastic substrates using simple, low-cost micromolding technique fabricate implantable devices stimulation recording. hydrogel electrodes show much lower electrochemical impedance higher charge storage injection capacity compared platinum electrodes. In addition, the of remain stable after long-term exposure extreme conditions. We demonstrate use hydrogel-based effective high-quality recordings in live animal models.

Language: Английский

Citations

0
Photovoltaic bioelectronics merging biology with new generation semiconductors and light in biophotovoltaics photobiomodulation and biosensing DOI Creative Commons
Ebin Joseph, Manuela Ciocca, Haodong Wu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Nov. 21, 2024

Abstract This review covers advancements in biosensing, biophotovoltaics, and photobiomodulation, focusing on the synergistic use of light, biomaterials, cells or tissues, interfaced with photosensitive dye-sensitized, perovskite, conjugated polymer organic semiconductors nanoparticles. Integration semiconductor biological systems, using non-invasive light-probes -stimuli for both sensing controlling behavior, has led to groundbreaking applications like artificial retinas. From fusion photovoltaics biology, a new research field emerges: photovoltaic bioelectronics.

Language: Английский

Citations

3
Soft Implantable Bioelectronics for the Management of Neurological Disorders and Cardiovascular Diseases DOI
Hye Jin Kim, Sung‐Hyuk Sunwoo, Ja Hoon Koo

et al.

Korean Journal of Chemical Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Language: Английский

Citations

2
Unlocking High-Efficiency Energy Storage and Conversion with Biocompatible Electrodes: The Key Role of Interfacial Interaction Assembly and Structural Design DOI Creative Commons
Jeongyeon Ahn,

H. G. Lim,

Jongkuk Ko

et al.

Energy Advances, Journal Year: 2024, Volume and Issue: 3(9), P. 2152 - 2174

Published: Jan. 1, 2024

This perspective paper covers textile- and hydrogel-based biocompatible electrodes, their applications for supercapacitors, biofuel cells, actuators, focusing on the importance of interfacial interactions between electrode components.

Language: Английский

Citations

1
Wirefree electrochemistry for enhanced detection and treatment of disease DOI Creative Commons

Oisín Foley Doyle,

Robert J. Forster

Electrochemistry Communications, Journal Year: 2024, Volume and Issue: 169, P. 107832 - 107832

Published: Nov. 2, 2024

Language: Английский

Citations

0
Soft Cardiac Patch Using a Bifacial Architecture of Adhesive/Low‐Impedance Hydrogel Nanocomposites and Highly Conductive Elastomer Nanocomposites DOI Creative Commons

Jeeyoung Kim,

Gi Doo, Minsung Kim

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Soft implantable multichannel cardiac electrode arrays that establish direct monolithic interfaces with the heart are key components for advanced monitoring and electrical modulation. A significant technological advancement in this area is development of stretchable conductive nanocomposites, fabricated through integration metallic nanomaterials elastic polymers, aimed at achieving both high conductivity mechanical elasticity. Despite these advances, further progress material performance device designs required to ensure seamless, reliable, biocompatible, high‐fidelity interfacing. Herein, a soft patch based on bifacial architecture adhesive/low‐impedance hydrogel nanocomposites highly elastomer reported. The design facilitates between other tissues/organs can be achieved. nanocomposite layer, positioned epicardial side, provides stable adhesion target tissue enables low‐impedance biocompatible interfacing heart, while opposite offers facile electrophysiological signal transfer low‐friction surface minimizing unwanted interactions surrounding tissues. effectiveness multiple applications involving various recordings electromechanical modulation demonstrations showcased.

Language: Английский

Citations

0
Tapping into tissue bioelectromechanics: Electroactive biopolymers for dynamic tissue engineering DOI Creative Commons

May Ayres Burgess,

Malavika Nair

APL Materials, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

The success of tissue engineering constructs in restoring healthy function is driven by the interplay cells with their microenvironmental cues. Therefore, design materials typically guided ensuring adequate mimicry and regulation dynamic biochemical, mechanical, electrical interactions that occur cellular extracellular milieu. In this work, we introduce current approaches limitations to static stimuli-responsive engineering, a focus on electroactive materials. We consider mechanisms material development polymers for soft robotics address how these developments can pave way ‘smart’ devices recapitulate key elements bioelectromechanics. By highlighting successes challenges support such devices, summarize our findings guidelines direct future clinically translatable efficacious functionality robots.

Language: Английский

Citations

0