Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders DOI Creative Commons
Lisa Croen, Jennifer Ames,

Yinge Qian

и другие.

Biological Psychiatry Global Open Science, Год журнала: 2023, Номер 4(1), С. 39 - 50

Опубликована: Окт. 11, 2023

Maternal inflammation can result from immune dysregulation and metabolic perturbations during pregnancy. Whether conditions associated with pregnancy increase the likelihood of autism spectrum (ASD) or other neurodevelopmental disorders (DD) is not well understood. We conducted a case-control study among children born in California 2011 – 2016 to investigate maternal immune-mediated cardiometabolic risk ASD (N=311) DD (N=1291) compared general population (GP, N=967). Data on covariates were retrieved electronic health records. genetic data used assess causal relationship. Using multivariable logistic regression, mothers asthma more likely deliver infants diagnosed (Odds Ratio (OR)=1.62, 95% Confidence Interval (CI): [1.15–2.29]) (OR=1.30, CI: [1.02–1.64]). obesity was (OR=1.51, [1.07–2.13]). The combination extreme demonstrated greatest odds (OR=16.9, [5.13–55.71]). These increased observed females only. Polygenic scores (PRS) for obesity, asthma, their showed no association ASD. Mendelian randomization did support relationship Inflammatory are children. Risks do appear be due shared risk, rather inflammatory may share non-genetic factors disorders. Children whose have both benefit earlier screening intervention.

Язык: Английский

Identification of shared genetic loci for asthma, allergic rhinitis, and pollinosis in East Asians DOI Creative Commons
Dong Wang, Shuai Liu, Qian Wu

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 19, 2025

Asthma, allergic rhinitis, and pollinosis are prevalent respiratory conditions that often co-occur, suggesting common genetic environmental causes. While significant progress has been made in identifying loci European populations, the architecture East Asian populations remains poorly understood. Using GWAS summary statistics from BioBank Japan, we performed multi-trait genome-wide association studies (MTAG) to quantify overlap among asthma, Asians. Genetic correlation analysis revealed positive correlations three conditions, stratified LDSC (Linkage Disequilibrium Score Regression) identified heritability enrichments Blood/Immune Digestive tissues. We discovered novel pleiotropic at 9q32 10q25.2 specific Asians, with candidate gene expression highlighting differential of AKNA, ATP6V1G1, GPAM. These findings provide new insights into shared biological mechanisms underlying these advancing our understanding their determinants potential therapeutic targets.

Язык: Английский

Процитировано

1
Asian diversity in human immune cells DOI Creative Commons

Kian Hong Kock,

Le Min Tan,

Kyung Yeon Han

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice DOI
Maxwell Salvatore, Ritoban Kundu, Xu Shi

и другие.

Journal of the American Medical Informatics Association, Год журнала: 2024, Номер 31(7), С. 1479 - 1492

Опубликована: Май 14, 2024

To develop recommendations regarding the use of weights to reduce selection bias for commonly performed analyses using electronic health record (EHR)-linked biobank data.

Язык: Английский

Процитировано

6
Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways DOI Creative Commons
Bernard Stikker, Lianne Trap, Bahareh Sedaghati-khayat

и другие.

European Respiratory Journal, Год журнала: 2024, Номер 64(2), С. 2302059 - 2302059

Опубликована: Июнь 20, 2024

Individual differences in susceptibility to developing asthma, a heterogeneous chronic inflammatory lung disease, are poorly understood. Whether genetics can predict asthma risk and how genetic variants modulate the complex pathophysiology of still debated.

Язык: Английский

Процитировано

6
Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders DOI Creative Commons
Lisa Croen, Jennifer Ames,

Yinge Qian

и другие.

Biological Psychiatry Global Open Science, Год журнала: 2023, Номер 4(1), С. 39 - 50

Опубликована: Окт. 11, 2023

Maternal inflammation can result from immune dysregulation and metabolic perturbations during pregnancy. Whether conditions associated with pregnancy increase the likelihood of autism spectrum (ASD) or other neurodevelopmental disorders (DD) is not well understood. We conducted a case-control study among children born in California 2011 – 2016 to investigate maternal immune-mediated cardiometabolic risk ASD (N=311) DD (N=1291) compared general population (GP, N=967). Data on covariates were retrieved electronic health records. genetic data used assess causal relationship. Using multivariable logistic regression, mothers asthma more likely deliver infants diagnosed (Odds Ratio (OR)=1.62, 95% Confidence Interval (CI): [1.15–2.29]) (OR=1.30, CI: [1.02–1.64]). obesity was (OR=1.51, [1.07–2.13]). The combination extreme demonstrated greatest odds (OR=16.9, [5.13–55.71]). These increased observed females only. Polygenic scores (PRS) for obesity, asthma, their showed no association ASD. Mendelian randomization did support relationship Inflammatory are children. Risks do appear be due shared risk, rather inflammatory may share non-genetic factors disorders. Children whose have both benefit earlier screening intervention.

Язык: Английский

Процитировано

13