Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 24, 2024
Язык: Английский
Molecular and Cellular Endocrinology, Год журнала: 2025, Номер unknown, С. 112448 - 112448
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 18, 2025
Summary Metabolic syndrome and excessive alcohol consumption result in liver injury fibrosis, which is characterized by increased collagen production activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown to facilitate production. However, LARP6 expression functionality as a regulator of fibrosis development disease relevant model remains elusive. By using snRNA-sequencing, we show that upregulated mainly HSCs patients. Moreover, knockdown human suppresses fibrogenic gene expression. integrating eCLIP analysis ribosome profiling HSCs, interacts with mature mRNAs comprising over 300 genes, including RNA structural elements within COL1A1 , COL1A2 COL3A1 regulate mRNA translation. Furthermore, HSC attenuates spheroids. Altogether, our results suggest targeting may provide new strategies for anti-fibrotic therapy. Highlights HSCs. reduces development. Of the hundreds targets, most mRNAs. regulates translation via interaction 5’UTRs.
Язык: Английский
Процитировано
0
Journal of Hepatology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from (MASL) to steatohepatitis (MASH) with fibrosis. Activation of Hepatic Stellate Cells (HSCs) into fibrogenic myofibroblasts plays a critical role in the pathogenesis MASH We compared transcriptome and chromatin accessibility human HSCs NORMAL, MASL, livers at single cell resolution. aimed identify genes that are upregulated activated determine which these key
Язык: Английский
Процитировано
4
ACS Pharmacology & Translational Science, Год журнала: 2025, Номер 8(3), С. 885 - 898
Опубликована: Фев. 24, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial chronic that can progress to metabolic steatohepatitis (MASH) and fibrosis, ultimately leading cirrhosis hepatocellular carcinoma. Oxidative stress believed play an important role in the development of MASH. Small aminothiol compounds such as cysteamine its oxidized precursor, cystamine, are known pleiotropic exhibit relatively potent antioxidant other effects. Herein, we evaluate efficacy well two deuterated derivatives, choline-deficient, L-amino acid-defined, high-fat-diet (CDAA-HFD) mouse model rapidly progressing fibrosis. Compared control mice, daily oral administration isotopically reinforced cystamine derivatives (200 mg/kg) led significant reduction fibrosis inflammation oxidative stress. Moreover, treatment appeared increase with deuteration state tetradeuterated derivative, d 4 -cystamine, being most effective. These results indicate hold promise potential candidates for
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2658 - 2658
Опубликована: Март 15, 2025
The burden of chronic liver disease (CLD) is dramatically increasing. It estimated that 20–30% the population worldwide affected by CLD. Hepatic fibrosis a symptom common to all CLDs. Although it affects functional activities, reversible stage if diagnosed at an early stage, but no resolutive therapy contrast currently available. Therefore, efforts are needed study molecular insights disease. Emerging cutting-edge fields in cellular and biology introducing innovative strategies. Spatial single-cell resolution approaches paving way for more detailed understanding mechanisms underlying fibrosis. Cellular models have been generated recapitulate in-a-dish pathophysiology fibrosis, yielding remarkable results not only uncover also serve as patient-specific avatars precision medicine. Induced pluripotent stem cells (iPSC) organoids incredible tools reshape modeling diseases, describe their architecture, residents hepatic tissue heterogeneous population. present work aims give overview omics technologies revolutionizing research current model this
Язык: Английский
Процитировано
0
JHEP Reports, Год журнала: 2025, Номер unknown, С. 101415 - 101415
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Hepatology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 24, 2024
Язык: Английский
Процитировано
0