Environmental Health Perspectives,
Год журнала:
2023,
Номер
131(1)
Опубликована: Янв. 1, 2023
Background:
The
gut
microbiome
plays
an
essential
role
in
human
health.
Despite
the
link
between
air
pollution
exposure
and
various
diseases,
its
association
with
during
susceptible
life
periods
remains
scarce.
Objectives:
In
this
study,
we
examined
black
carbon
particles
quantified
prenatal
postnatal
biological
matrices
bacterial
richness
diversity
measures,
families.
Methods:
A
total
of
85
stool
samples
were
collected
from
4-
to
6-y-old
children
enrolled
ENVIRonmental
influence
ON
early
AGEing
birth
cohort.
We
performed
16S
rRNA
gene
sequencing
calculate
indices
(Chao1
richness,
Shannon
diversity,
Simpson
diversity)
relative
abundance
Black
via
white
light
generation
under
femtosecond
pulsed
laser
illumination
placental
tissue
cord
blood,
employed
as
biomarkers,
urine,
used
a
post-natal
biomarker.
robust
multivariable-adjusted
linear
models
examine
associations
loads
measures
index)
(Shannon
indices),
adjusting
for
parity,
season
delivery,
batch,
age,
sex,
weight
height
child,
maternal
education.
Additionally,
differential
analysis
families
correction
sampling
fraction
bias.
Results
are
expressed
percentage
difference
doubling
95%
confidence
interval
(CI).
Results:
Two
negatively
associated
[Shannon:
−4.38%
(95%
CI:
−8.31%,
−0.28%);
Simpson:
−0.90%
−1.76%,
−0.04%)],
blood
−3.38%
−5.66%,
−0.84%);
−0.91
−1.66%,
−0.16%)],
urinary
−3.39%
−5.77%,
−0.94%);
−0.89%
−1.37%,
−0.40%)].
explained
variance
on
above
varied
6.1%
16.6%.
No
statistically
significant
found
load
Chao1
index.
After
multiple
testing
correction,
was
Defluviitaleaceae
Marinifilaceae,
Christensenellaceae
Coriobacteriaceae;
not
after
correction.
Conclusion:
composition
childhood
intestinal
microbiome.
These
findings
address
influential
pregnancy
https://doi.org/10.1289/EHP11257
Nutrients,
Год журнала:
2022,
Номер
14(13), С. 2661 - 2661
Опубликована: Июнь 27, 2022
The
involvement
of
the
gut
microbiota
and
metabolites
colon-residing
bacteria
in
brain
disease
pathogenesis
has
been
covered
a
growing
number
studies,
but
comparative
literature
is
scarce.
To
fill
this
gap,
we
explored
contribution
microbiota-gut-brain
axis
to
pathophysiology
seven
brain-related
diseases
(attention
deficit
hyperactivity
disorder,
autism
spectrum
schizophrenia,
Alzheimer's
disease,
Parkinson's
major
depressive
bipolar
disorder).
In
article,
discussed
changes
bacterial
abundance
metabolic
implications
these
on
development
progression.
Our
central
findings
indicate
that,
mechanistically,
all
are
associated
with
leaky
gut,
neuroinflammation,
over-activated
microglial
cells,
which
gut-residing
their
important
contributors.
Patients
show
pro-inflammatory
shift
colon
microbiota,
harbouring
more
Gram-negative
containing
immune-triggering
lipopolysaccharides
(LPS)
cell
walls.
addition,
properties
(
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 28, 2024
The
influence
of
gut
microbiota
on
physiological
processes
is
rapidly
gaining
attention
globally.
Despite
being
under-studied,
there
are
available
data
demonstrating
a
microbiota-gonadal
cross-talk,
and
the
importance
this
axis
in
reproduction.
This
study
reviews
impacts
In
addition,
possible
mechanisms
by
which
modulates
male
female
reproduction
presented.
Databases,
including
Embase,
Google
scholar,
Pubmed/Medline,
Scopus,
Web
Science,
were
explored
using
relevant
key
words.
Findings
showed
that
promotes
gonadal
functions
modulating
circulating
levels
steroid
sex
hormones,
insulin
sensitivity,
immune
system,
microbiota.
Gut
also
alters
ROS
generation
activation
cytokine
accumulation.
conclusion,
demonstrate
existence
axis,
role
functions.
However,
majority
compelling
evidences
from
animal
studies
with
great
dearth
human
data.
Therefore,
validating
reports
experimental
models
important.
Recent
studies
revealed
a
significant
role
of
the
gut
fungal
community
in
human
health.
Here,
we
investigated
content
and
variation
mycobiota
among
subjects
from
European
population.
We
explored
interplay
between
fungi
various
host-related
sociodemographic,
lifestyle,
health,
dietary
factors.
The
study
included
923
participants.
Fecal
DNA
samples
were
analyzed
by
whole-metagenome
high-throughput
sequencing.
Subsequently,
taxonomic
profiles
determined
accompanied
computational
statistical
analyses
association
with
53
Fungal
communities
characterized
high
prevalence
Saccharomyces,
Candida,
Sporisorium.
Ten
factors
found
to
correlate
significantly
overall
variation.
Most
diet
related,
including
consumption
chips,
meat,
sodas,
sweetening,
processed
food,
alcohol,
followed
age
marital
status.
Differences
α-
and/or
β-diversity
also
reported
for
other
such
as
body
mass
index
(BMI),
job
type,
autoimmunological
diseases,
probiotics.
Differential
abundance
analysis
species
that
exhibited
different
patterns
changes
under
specific
conditions.
is
dominated
yeast,
Malassezia,
Candida.
Although
intervolunteer
variability
was
high,
several
persisted
across
most
samples,
which
may
be
evidence
core
exists.
Moreover,
showed
diet,
age,
status
influence
mycobiota.
To
our
knowledge,
this
first
large
comprehensive
cohort
terms
associations
an
extensive
differentiated
set
IMPORTANCE
inhabited
many
organisms,
bacteria
fungi,
affect
However,
research
on
mycobiome
still
rare.
European-based
missing.
Our
results
beer,
alcohol
consumption,
associated
abundances
at
level
can
suggest
potentially
valuable
paths
further,
narrowly
focused
its
impact
In
coming
era
microbiome-based
precision
medicine,
further
into
relationship
mycobial
structures
result
new
preventive
approaches
or
therapeutic
procedures.
Biomedicines,
Год журнала:
2024,
Номер
12(5), С. 1023 - 1023
Опубликована: Май 7, 2024
The
synergic
role
of
vitamin
D
and
the
intestinal
microbiota
in
regulation
immune
system
has
been
thoroughly
described
literature.
Vitamin
deficiency
dysbiosis
have
shown
a
pathogenetic
development
numerous
immune-mediated
allergic
diseases.
physiological
processes
underlying
aging
sex
proven
to
be
capable
having
negative
influence
both
on
values
biodiversity
microbiome.
This
leads
global
increase
levels
systemic
inflammatory
markers,
with
potential
implications
for
all
diseases
conditions.
Our
review
aims
collect
analyze
relationship
between
microbiome
associated
it,
emphasizing
effect
mediated
by
sexual
hormones
aging.
Applied Microbiology and Biotechnology,
Год журнала:
2024,
Номер
108(1)
Опубликована: Янв. 17, 2024
Abstract
This
research
investigates
the
effects
of
phytogenic
feed
additives
(PFAs)
on
growth
performance,
gut
microbial
community,
and
metabolic
functions
in
weaned
piglets
via
a
combined
16S
rRNA
gene
amplicon
shotgun
metagenomics
approach.
A
controlled
trial
was
conducted
using
200
pigs
to
highlight
significant
influence
PFAs
microbiota
dynamics.
Notably,
treatment
group
revealed
an
increased
diversity,
as
measured
with
Shannon
Simpson
indices.
The
increase
diversity
is
accompanied
by
beneficial
bacterial
taxa,
such
Roseburia
,
Faecalibacterium
Prevotella
decline
potential
pathogens
like
Clostridium
sensu
stricto
1
Campylobacter
.
Shotgun
sequencing
at
species
level
confirmed
these
findings.
modification
profile
coupled
altered
pathways,
suggesting
reconfiguration
function
under
PFA
influence.
Significant
shifts
overall
community
structure
week
8
demonstrate
treatment’s
temporal
impact.
Histomorphological
examination
unveiled
improved
PFA-treated
piglets.
results
this
study
indicate
that
use
dietary
supplements
can
be
effective
strategy,
augmenting
reshaping
function,
enhancing
structure,
optimising
intestinal
health
providing
valuable
implications
for
swine
production.
Key
points
•
significantly
diversify
piglets,
aiding
balance
Changes
due
resistance
weaning
stress
show
ease
stress,
offering
substitute
antibiotics
piglet
diets
