Microbes Saving Lives and Reducing Suffering
Microbial Biotechnology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Changes in Hormonal Profile and Body Mass Index in Women with Polycystic Ovary Syndrome After Probiotic Intake: A 12-Week Placebo-Controlled and Randomized Clinical Study
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 405 - 405
Опубликована: Янв. 23, 2025
Introduction:
The
beneficial
effect
of
probiotics
on
the
improvement
carbohydrate
and
lipid
metabolism,
as
well
body
mass
index
(BMI),
has
been
demonstrated
in
various
patient
groups.
We
aimed
to
investigate
a
multi-strain
probiotic
hormonal
balance
women
with
PCOS.
Ethical
approval
was
obtained
from
Bioethical
Committee.
Methods:
study
designed
12-week,
randomized,
double-blind,
placebo-controlled
clinical
study.
SanProbi®
Barrier
capsules,
which
contain
unique
composition
nine
bacteria
strains
(Lactobacillus
Biffidobacterium),
were
used
mean
age
participants
28.42
±
5.62
years.
A
total
50
PCOS,
diagnosed
based
Rotterdam
ESHRE
criteria,
included
Among
them,
25
randomized
placebo
group,
group.
Results:
comparison
changes
individual
hormone
levels
between
groups
confirmed
statistically
significant
differences
for
TSH,
androstenedione,
SHBG,
BMI.
In
case
LH,
statistical
significance
difference
delta
change
group
use
one-tailed
test.
Conclusions:
Probiotic
supplementation
may
serve
an
alternative
supporting
treatment,
especially
phenotype
high
FAI
index.
therapy
is
also
effective
reducing
BMI
overweight
PCOS
Язык: Английский
Introduction to Polycystic Ovary Syndrome (PCOS) and Nutritional Challenges
Опубликована: Янв. 1, 2025
Язык: Английский
The association between triglyceride glucose-body Mass Index and in vitro fertilization outcomes in women with polycystic ovary syndrome: a cohort study
Journal of Ovarian Research,
Год журнала:
2024,
Номер
17(1)
Опубликована: Апрель 26, 2024
Abstract
Background
Polycystic
Ovary
Syndrome
(PCOS)
is
a
common
reproductive
disorder
that
frequently
affects
fertility.
The
TyG-BMI
(Triglyceride
glucose-body
mass)
index
newly
explored
parameter
may
be
linked
to
results
in
individuals
with
PCOS.
Nevertheless,
its
connection
outcomes
In
Vitro
Fertilization
(IVF)
procedures
remains
uncertain.
Methods
This
study
included
total
of
966
females
who
underwent
IVF
treatments
for
At
the
baseline,
participants
were
categorized
into
four
groups
according
quartiles
measured
prior
oocyte
retrieval.
Subsequently,
compared
differences
clinical
and
laboratory
among
these
groups.
Results
Patients
higher
exhibited
decreased
number
retrieved
oocytes,
2PN
embryos,
available/high-quality
embryos
(
P
<
0.05
Q1-Q4).
Additionally,
multivariable
regression
analysis
revealed
top
quartile
had
lower
count
accessible
(β
=
-0.224,
0.257)
high-quality
-0.352,
0.028)
comparison
those
lowest
quartile.
there
no
notable
variances
detected
rates
pregnancy
or
live
births
quartiles.
Furthermore,
linear
correlation
was
noted
between
quantity
-non-linear
0.6,
-overall
0.001),
along
-nonlinear
0.026,
0.006).
contrast,
found
available
embryo
rate
0.60,
0.8).
Conclusions
this
research
emphasize
diagnosed
interplay
insulin
resistance
disorders
lipid
metabolism
indeed
play
pivotal
role
influencing
assisted
patients
Considering
findings,
proves
valuable
indicator
exploring
potential
association.
Язык: Английский
The modern pathogenetic challenges of polycystic ovary syndrome
Reproductive health of woman,
Год журнала:
2024,
Номер
2, С. 75 - 80
Опубликована: Март 9, 2024
Polycystic
ovary
syndrome
(PCOS)
is
one
of
the
neuroendocrine
syndromes
in
women
reproductive
age.
In
pathogenesis
its
development
a
great
importance
paid
to
hormonal
disbalance,
metabolic
changes,
overweight
and
obesity,
diabetes
mellitus,
insulin
resistance,
genetic
factors,
etc.
Very
often,
PCOS
accompanied
by
infertility,
cardiovascular
risks,
mellitus.The
article
devoted
review
modern
scientific
literature
about
last
researches
mechanisms
disorders
which
are
connected
with
also,
psychological
disturbance
stress.
The
describes
specific
conditions
patients.
On
basis
analyzed
publications
connection
between
disorders,
overweight,
obesity
lipidogram
parameters
presented.Also,
gut
vaginal
microbiota
described
this
paper.
studies
demonstrate
significant
changes
human
microbiome
course
polycystic
syndrome.
presents
concepts
difference
composition
vagina
syndrome.The
pathogenetic
role
processes
pathogenesis,
namely,
regulation
immune
response
inflammation
pathology,
described.
It
has
been
shown
that
there
differences
microflora
intestines,
manifested
decreased
concentration
Lactobacillus
presence
variety
other
microorganisms
compared
healthy
women.Thus,
main
links
closely
each
other.
That
why
multimodal
approaches
for
study
management
patients
extremely
important.
Язык: Английский
Butyrate as a Potential Modulator in Gynecological Disease Progression
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4196 - 4196
Опубликована: Дек. 4, 2024
This
review
investigates
the
therapeutic
potential
of
butyrate,
a
short-chain
fatty
acid
(SCFA)
produced
by
gut
microbiota,
in
prevention
and
treatment
various
gynecological
diseases,
including
polycystic
ovary
syndrome
(PCOS),
endometriosis,
gynecologic
cancers
like
cervical
ovarian
cancer.
These
conditions
often
pose
challenges,
with
conventional
therapies
offering
limited
temporary
relief,
significant
side
effects,
risk
recurrence.
Emerging
evidence
highlights
butyrate's
unique
biological
activities,
particularly
its
role
as
histone
deacetylase
(HDAC)
inhibitor,
which
allows
it
to
modulate
gene
expression,
immune
responses,
inflammation.
In
PCOS,
butyrate
aids
restoring
hormonal
balance,
enhancing
insulin
sensitivity,
reducing
chronic
For
appears
suppress
dysregulation
minimize
lesion
proliferation.
Additionally,
cancers,
demonstrates
anticancer
effects
through
mechanisms
such
cell
cycle
arrest,
apoptosis
induction,
suppression
tumor
progression.
Dietary
interventions,
high-fiber
Mediterranean
diets,
that
increase
production
are
proposed
complementary
approaches,
supporting
natural
microbiota
modulation
enhance
outcomes.
However,
short
half-life
limits
clinical
application,
spurring
interest
analogs
probiotics
maintain
stable
levels
extend
benefits.
consolidates
current
findings
on
multifaceted
impact
across
health,
highlighting
for
microbiota-centered
advancing
strategies
improving
women's
reproductive
health.
Язык: Английский
Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring?
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1628 - 1628
Опубликована: Июль 23, 2024
Endocrine-disrupting
chemicals
(EDCs)
have
become
so
pervasive
in
our
environment
and
daily
lives
that
it
is
impossible
to
avoid
contact
with
such
compounds,
including
pregnant
women
seeking
minimize
exposures
themselves
their
unborn
children.
Developmental
exposure
of
humans
rodent
models
bisphenol
A
(BPA)
other
EDCs
linked
increased
anxiogenic
behaviors,
learning
memory
deficits,
decreased
socio-sexual
behaviors.
Prenatal
BPA
leads
longstanding
harmful
effects
on
gut
microbiota
reductions
beneficial
bacteria,
i.e.,
dysbiosis,
microbial
changes
are
host
fecal
metabolites,
those
involved
carbohydrate
metabolism
synthesis,
neurobehavioral
alterations
adulthood,
particular,
social
cognitive
deficits.
Gut
dysbiosis
increasingly
being
recognized
as
a
key
driver
myriad
diseases,
ranging
from
metabolic,
cardiovascular,
reproductive,
disorders
via
the
gut-microbiome-brain
axis.
Thus,
might
induce
indirect
physical
mental
health
by
acting
microbiome-disrupting
chemicals.
Findings
raise
important
question
whether
should
consume
probiotic
supplement
mitigate
pernicious
EDCs,
especially
BPA,
offspring.
Current
studies
investigating
maternal
supplementation
women's
offspring
will
be
reviewed.
Data
inform
potential
application
reverse
unwittingly
exposed
these
compounds
striving
give
best
start
life.
Язык: Английский
Gut microbiota biodiversity indices as markers of hyperandrogenemia in women of reproductive age
Acta Biomedica Scientifica (East Siberian Biomedical Journal),
Год журнала:
2024,
Номер
9(4), С. 12 - 18
Опубликована: Сен. 25, 2024
Introduction.
Pr
eviously
,
it
was
shown
that
the
“classic”
phenotypes
of
polycystic
ovarian
syndrome
(PCOS)
are
associated
with
significant
decrease
in
gut
microbiota
alpha
diversity
as
compared
healthy
women.
The
aim
study.
T
o
establish
cut-off
points
for
indices,
hyperandrogenism.
Material
and
methods.
he
manuscript
pr
esents
a
sub-study
Eastern
Siberia
PCOS
Epidemiology
Phenotype
Study,
conducted
(Russia)
from
2016
to
2019.
All
participants
(175
women
reproductive
age:
26
(according
Rotterdam
criteria
(2003))
hyperandrogenemia
(increased
levels
total
testosterone
(TT)
and/or
free
androgenindex(FAI),
and/ordehydroepiandrosterone
sulphate
(DHEAS)),
149
–
without
hyperandrogenemia)
were
recruited
during
annual
employment
medical
assessment.
Methods
included
questionnaire
survey,
anthropometry
modified
Ferriman
Gallwey
score,
gynecological
examination,
pelvic
ultrasound,
blood
serum
tests
TT,
DHEAS,
sex
hormone-binding
globulin,
FAI,
prolactin,
thyroid-stimulating
hormone,
17-hydroxyprogesterone.
Five
indices
(amplicon
sequencing
variant,
Shannon
index,
Simpson
Chao
abundance-based
coverage
Index)
estimated
using
amplicon
metasequencing.
Statistical
analysis
ROC-analysis
development
hyperandrogenism
age
PCOS.
Results
.
According
t
results
ROC-analysis,
greatest
sensitivity
moderate
specificity,
high
area
under
curve
established
classifying
or
5.84
0.97,
respectively.
Conclusions.
developed
assessing
most
can
be
useful
monitoring
different
therapeutic
interventions
(prebiotics,
probiotics,
etc.)
hyperandrogenic
Язык: Английский
Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data
EClinicalMedicine,
Год журнала:
2024,
Номер
77, С. 102884 - 102884
Опубликована: Окт. 18, 2024
Язык: Английский
Association of SOGPI in mediating the effect of Phosphatidylcholine on polycystic Ovary Syndrome
Gynecological Endocrinology,
Год журнала:
2024,
Номер
40(1)
Опубликована: Окт. 26, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
prevalent
endocrine
disorder
in
women
of
reproductive
age,
marked
by
hormonal
imbalances
and
disruptions
glucose
lipid
metabolism.
Emerging
research
has
indicated
correlation
between
lipids
PCOS,
yet
the
specific
profiles
or
associated
genes
identified
various
studies
vary,
observational
data
alone
cannot
establish
causation.
Therefore,
our
study
seeks
to
causal
association
lipidome
PCOS.
Язык: Английский