Applying minimally invasive biomarkers of chronic stress across complex ecological contexts

American Journal of Human Biology, Год журнала: 2022, Номер 34(11)

Опубликована: Окт. 6, 2022

Chronic stress is both theoretically and methodologically challenging to operationalize through biomarkers. Yet minimally invasive, field-friendly biomarkers of chronic are valuable in research linking biology culture, seeking understand differential patterns human development across ecological contexts, exploring the evolution sociality. For biologists, a central question measurement interpretation how stress-responsive physiological systems regulated diverse ecologies. This article aims describe conditional toolkit for biologists interested study stress, highlighting mix longstanding novel biomarkers, with special focus on hair/fingernail cortisol, latent herpesvirus antibodies, allostatic load indices, serial/ambulatory data collection approaches. Future trends biomarker research, including epigenetic approaches, briefly considered. overview considers: (1) challenges separating distinctly psychosocial dimension from adversity more broadly; (2) essential characteristics ecology that shape interpretation; (3) retrospective vs. longitudinal sampling; (4) role age, developmental effects, local biologies; (5) different timescales chronicity; (6) culture.

Язык: Английский

---

Expanding the frame around social dynamics and glucocorticoids: From hierarchies within the nest to competitive interactions among species

Hormones and Behavior, Год журнала: 2022, Номер 144, С. 105204 - 105204

Опубликована: Июнь 8, 2022

Язык: Английский

---

Measurement invariance of the Occupational Depression Inventory: a study of 12,589 participants across 14 countries

Work & Stress, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Июнь 7, 2024

The Occupational Depression Inventory (ODI) reflects a novel approach to job-related distress anchored in depression research. To date, the extent which ODI exhibits measurement invariance across countries, languages, and demographics is unclear. Measurement refers whether measure has same structure, or meaning, groups of interest. thus crucial for between-group comparisons study replicability. This estimated 14 countries – Australia, Brazil, France, Germany, Italy, New Zealand, Norway, Poland, Portugal, South Africa, Spain, Sweden, Switzerland, USA 10 languages as well sexes age (pooled N = 12,589). We found evidence complete (configural, weak, strong, strict) sexes, groups. Looking into structural parameters, we latent variance-covariance hold be equivocal Expectedly, levels occupational depression, indexed by means, varied within four categories. Our results indicate that behaves similarly findings support use with respondents having different cultural backgrounds individual characteristics.

Язык: Английский

---

Stress responsiveness in a wild primate predicts survival across an extreme El Niño drought

Science Advances, Год журнала: 2025, Номер 11(4)

Опубликована: Янв. 22, 2025

We know more about the costs of chronic stress than benefits acute response—an adaptive response that buffers organisms from life-threatening challenges. As yet, no primate study has empirically identified how adaptively affects evolutionary fitness. Here, we take advantage a natural experiment—an El Niño drought—that produced unprecedented mortality for wild white-faced capuchins. Using reaction norm approach, provide evidence primates robust to challenge, measured using fecal glucocorticoids, predicts greater likelihood survival. show individuals with responsiveness previous droughts later had higher survival across severe drought. Evolutionary models need empirical data on responsivity varies in ways. While cannot buffer subjects catastrophic events, can use them understand which aspects help animals “weather storm.”

Язык: Английский

---

Effects of variations in daily cortisol pattern and long-term cortisol output on hippocampal subfield volumes in adult human brain.

Biological Psychiatry Global Open Science, Год журнала: 2025, Номер 5(3), С. 100458 - 100458

Опубликована: Фев. 6, 2025

Animal models of adult chronic stress indicate that the cornu ammonis 1-3 (CA1-3) and dentate gyrus (DG) hippocampal subfields are most susceptible to cellular changes associated with prolonged psychogenic stressors glucocorticoid overexposure. However, no study reported date has examined associations between long-term cortisol output, stress, subfield volumes in healthy adults experiencing different levels stress. The main goal current was test whether higher output measured by hair concentration would be atrophy CA1-3 DG subfields. We short- (N = 40). High-resolution structural magnetic resonance imaging datasets were acquired together diurnal salivary measures. Hair analyzed using high-resolution liquid chromatography-mass spectrometry method. Higher smaller all anterior hippocampus both posterior hippocampus. found a larger increase morning level after awakening volumes, while decrease afternoon from volume observed not predicted individual or history childhood trauma. Our results suggest increased daily fluctuations can have negative impact on

Язык: Английский

---

Advanced capabilities for in vitro stress diagnostics: a review

Bulletin of Rehabilitation Medicine, Год журнала: 2025, Номер 24(1), С. 67 - 74

Опубликована: Фев. 25, 2025

INTRODUCTION. The effects of stress negatively affect both physical and mental health. Recently, there has been a sharp increase in interest studying evidence-based methods for diagnosing effective interventions its correction. AIM. Comprehensive assessment modern possibilities objectification using laboratory diagnostics markers based on data from literary sources. MATERIALS AND METHODS. To select publications, we studied the PubMed, Web Science (Web Core Collection Medline), Cochrane Library databases, included meta-analyses review articles, full-text articles investigating relationship between biomarkers stress. search depth publications was 10 years, 2014 to 2024, number earlier, fundamental works neurophysiology were also review. RESULTS DISCUSSION. biological basis manifestations is growing area scientists, as evidenced by increasing cortisol dehydroepiandrosterone (DHEA) over past years. reflects view role diagnostics. Biomarkers such (the level surge after awakening, average during day, daily curve cortisol, hair), salivary alpha-amylase, DHEA, etc. are described, information their sensitivity specificity verification acute chronic conditions analyzed. CONCLUSION. Cortisol most reliable frequently used marker stress, while study other potential continues grow. Psychometric questionnaires functional diagnostic reflecting degree sympathetic activation widely integrated use various tools, including will provide multimodal approach, contribute more complete picture response conditions.

Язык: Английский

---

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A Ecological and Integrative Physiology, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

ABSTRACT The ability of organisms to effectively respond challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population Leach's storm‐petrels ( Hydrobates leucorhous) . conducted standardized 20‐min handling procedure on storm‐petrel chicks collected baseline post‐handling blood samples. measured plasma corticosterone red cell levels through the detection mutated base 8‐Hydroxy‐2'‐deoxyguanosine (8‐OHdG). In addition, we quantified six measures aerobic metabolism from cells. Overall, increased decreased efficiency produce ATP. Although increase was inversely related change damage, decrease positively correlated with damage. Thus, over stress response, individuals who had largest also least amount prioritized ATP production during showed higher This work highlights complex pathways by which affect stress, providing new insights into trade‐offs underlying physiological responses animals.

Язык: Английский

---

“Dear Enemies”, “Nasty Neighbors”, and the Strength in Numbers: Exploring the Behavioral and Hormonal Responses of Mantled Howler Monkey Males to Simulated Intruder Loud Calls

American Journal of Primatology, Год журнала: 2025, Номер 87(4)

Опубликована: Март 31, 2025

ABSTRACT Loud calls are critical for primate intergroup communication, influencing resource defense, territorial boundaries, and conflict management. This study examined the interplay of familiarity numeric odds in shaping behavioral hormonal responses male mantled howler monkeys ( Alouatta palliata ) to simulated intruder calls. Using playback experiments, we tested whether were consistent with “dear enemy” dynamics, which predict stronger unfamiliar intruders, or “nasty neighbor” familiar intruders. Additionally, assessed influence odds, hypothesizing under favorable conditions. Behavioral responses, including vocalization approach latencies, primarily influenced by shorter latencies observed odds. Vocal duration, however, was longer when intruders familiar, dynamics. Hormonal measured via fecal glucocorticoid testosterone metabolites, increased response supporting predictions. Interaction effects showed that modulated duration latency unfavorable. These findings reveal distinct roles immediate prolonged Numeric engagement decisions, while related stress‐related changes vocal communication strategies. contributes understanding dynamics clarifying role competitive asymmetries social relationships Future work incorporating multimodal cues ecological variability will further elucidate adaptive significance these responses.

Язык: Английский

---

NEUROBIOLOGICAL ASPECTS OF PATHOGENETIC MECHANISMS IN THE DEVELOPMENT OF POST-TRAUMATIC STRESS DISORDER (LITERATURE REVIEW)

Eastern Ukrainian Medical Journal, Год журнала: 2025, Номер 13(1), С. 39 - 54

Опубликована: Янв. 1, 2025

Post-traumatic stress disorder (PTSD) occurs as a result of exposure to life-threatening traumatic event or situation involving violence. The main manifestations PTSD are obsessive re-experiencing the event, increased nervous arousal, avoidance stimuli related emotional and cognitive disorders that persist for long time. This mental is exhausting causes changes make it difficult sometimes impossible patients with function professionally socially. results in significant clinical burden high socioeconomic costs. Materials methods. authors have reviewed more than 100 scientific papers from world literature on problems diagnosis, symptoms, pathophysiological neurobiological mechanisms play an important role development can be used key elements choice treatment measures. Results. multifactorial disease, therefore, numerous factors involved its occurrence progression. immediate response activation neuroendocrine autonomic systems release adrenaline norepinephrine. involvement hypothalamic-pituitary-adrenal system subsequent secretion cortisol may trigger development. A link has been found between activity noradrenergic system, glucocorticoid exposure, impaired interaction neurons amygdala prefrontal cortex. In addition, glucocorticoids associated immune neuroinflammation. Inflammatory cytokines regulate modify functioning neurotransmitters such serotonin dopamine, which contributes onset progression symptoms. Conclusions. data large number studies allow us confirm following pathogenesis PTSD. These include vegetative regulation, dysfunction immunological regulatory inflammatory mechanisms, dysregulation monoaminergic transmission system. Further study pathogenetic pathways will better implementation strategy medical care

Язык: Английский

---

Slumber under pressure: REM sleep and stress response

Progress in Neurobiology, Год журнала: 2025, Номер unknown, С. 102771 - 102771

Опубликована: Апрель 1, 2025

Язык: Английский

---