Advances in the Elimination of Viral Hepatitis in Mexico: A Local Perspective on the Global Initiative DOI Creative Commons
Gerardo Santos‐López, Arturo Panduro, Francisca Sosa-Jurado

и другие.

Pathogens, Год журнала: 2024, Номер 13(10), С. 859 - 859

Опубликована: Окт. 1, 2024

Viral hepatitis (A–E) presents a major global health challenge. In 2015, the World Health Organization (WHO) launched an initiative to eliminate viral hepatitis, with aim of reducing new infections by 90% and deaths 65% 2030. Mexico is one 38 focus countries identified WHO, collectively accounting for 80% deaths. While B C are commonly diagnosed in Mexico, routine diagnosis D E lacking, no specific epidemiological data available. 2020, implemented National Hepatitis Elimination Program, focusing on preventing infections, complications like cirrhosis hepatocellular carcinoma, ensuring access treatment, improving patient care. However, this program has not been extended E. Addressing challenges control requires increased resource allocation, expanded diagnosis, vaccination A B, treatment coverage C, along multisectoral engagement. This work provides overview Mexico’s response initiative, highlighting its progress, challenges, areas opportunity.

Язык: Английский

Global Temporal Trends And Projections of Acute Hepatitis E Incidence Among Women of Childbearing Age: Age-Period-Cohort Analysis 2021 DOI Creative Commons

Deliang Huang,

Huiyi Lai,

Xia Shi

и другие.

Journal of Infection, Год журнала: 2024, Номер 89(4), С. 106250 - 106250

Опубликована: Авг. 23, 2024

Acute hepatitis E (AHE) poses a significant threat to global public health, particularly among women of childbearing age (WCBA), who are at heightened risk for severe pregnancy-related complications. This study aimed delineate the temporal trends and project future incidence AHE in WCBA, providing insights crucial targeted prevention control strategies.

Язык: Английский

Процитировано

23
Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies DOI Creative Commons

Angela Quirino,

Nadia Marascio, Francesco Branda

и другие.

Pathogens, Год журнала: 2024, Номер 13(9), С. 766 - 766

Опубликована: Сен. 5, 2024

Viral hepatitis is a major cause of liver illness worldwide. Despite advances in the understanding these infections, pathogenesis remains complex process driven by intricate interactions between viruses and host cells at molecular level. This paper will examine detail dynamics host-pathogen interactions, highlighting key mechanisms that regulate virus entry into hepatocyte, their replication, evasion immune responses, induction hepatocellular damage. The unique strategies employed different viruses, such as B, C, D, E to exploit metabolic cell signaling pathways advantage be discussed. At same time, innate adaptive responses put place counter viral infection analyzed. Special attention paid genetic, epigenetic, environmental factors modulate individual susceptibility forms hepatitis. In addition, this work highlight latest findings on persistence leading chronic state potential implications for development new therapeutic strategies. Fully crucial identifying targets, developing more effective approaches treatment, shedding light underlying progression advanced stages

Язык: Английский

Процитировано

3
Production and Characterization of Self-Assembled Virus-like Particles Comprising Capsid Proteins from Genotypes 3 and 4 Hepatitis E Virus (HEV) and Rabbit HEV Expressed in Escherichia coli DOI Creative Commons
Tominari Kobayashi, Masaharu Takahashi, Satoshi Ohta

и другие.

Viruses, Год журнала: 2024, Номер 16(9), С. 1400 - 1400

Опубликована: Авг. 31, 2024

The zoonotic transmission of hepatitis E virus (HEV) genotypes 3 (HEV-3) and 4 (HEV-4), rabbit HEV (HEV-3ra) has been documented. Vaccination against infection depends on the capsid (open reading frame 2, ORF2) protein, which is highly immunogenic elicits effective virus-neutralizing antibodies. Escherichia coli (E. coli) utilized as an system for producing HEV-like particles (VLPs). However, research production ORF2 proteins from these in E. to form VLPs modest. In this study, we constructed 21 recombinant plasmids expressing various N-terminally C-terminally truncated HEV-3, HEV-3ra, HEV-4 coli. We successfully obtained nine two ten proteins, were primarily localized inclusion bodies. These solubilized M urea, filtered, subjected gel filtration. Results revealed that six one could assemble into VLPs. purified displayed molecular weights ranging 27.1 63.4 kDa demonstrated high purity (74.7–95.3%), assessed by bioanalyzer, with yields 13.9–89.6 mg per 100 mL TB medium. Immunoelectron microscopy confirmed origin ORF2. Antigenicity testing indicated possess characteristic antigenicity. Evaluation immunogenicity Balb/cAJcl mice robust anti-HEV IgG responses, highlighting potential immunogens. findings suggest generated different serve valuable tools vaccine development.

Язык: Английский

Процитировано

1
Palmitoylation-dependent association with Annexin II directs hepatitis E virus ORF3 sorting into vesicles and quasi-enveloped virions DOI Creative Commons
Xing Liu, Tianxu Liu,

Zhen Shao

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 122(1)

Опубликована: Дек. 30, 2024

Historically considered to be nonenveloped, hepatitis E virus (HEV), an important zoonotic pathogen, has recently been discovered egress from infected cells as quasi-enveloped virions. These virions circulating in the blood are resistant neutralizing antibodies, thereby facilitating stealthy spread of infection. Despite abundant evidence essential role HEV-encoded ORF3 protein formation, underlying mechanism remains unclear. Here, we demonstrate that HEV possesses inherent capacity for self-secretion and palmitoylation at two cysteine residues within N-terminal region is its secretion formation. We further found only palmitoylated proteins hijacked Annexin II transport cytoskeleton then directed into multivesicular bodies through nSMase-endosomal sorting complexes required transport-III pathway secretion. Finally, show infection gerbils with mutants harboring mutations sites showed no fecal viral shedding but competent replication liver. Our study fills a gap understanding assembly release mediated by offers potential designing therapeutic strategies control

Язык: Английский

Процитировано

1
A Hepatitis E Virus Infection Model in the Mongolian Gerbil: Ready for Antiviral and Vaccine Studies DOI Open Access
Jérôme Gouttenoire, Johan Neyts

Gastroenterology, Год журнала: 2024, Номер 167(4), С. 652 - 653

Опубликована: Май 23, 2024

Язык: Английский

Процитировано

0
Advances in the Elimination of Viral Hepatitis in Mexico: A Local Perspective on the Global Initiative DOI Creative Commons
Gerardo Santos‐López, Arturo Panduro, Francisca Sosa-Jurado

и другие.

Pathogens, Год журнала: 2024, Номер 13(10), С. 859 - 859

Опубликована: Окт. 1, 2024

Viral hepatitis (A–E) presents a major global health challenge. In 2015, the World Health Organization (WHO) launched an initiative to eliminate viral hepatitis, with aim of reducing new infections by 90% and deaths 65% 2030. Mexico is one 38 focus countries identified WHO, collectively accounting for 80% deaths. While B C are commonly diagnosed in Mexico, routine diagnosis D E lacking, no specific epidemiological data available. 2020, implemented National Hepatitis Elimination Program, focusing on preventing infections, complications like cirrhosis hepatocellular carcinoma, ensuring access treatment, improving patient care. However, this program has not been extended E. Addressing challenges control requires increased resource allocation, expanded diagnosis, vaccination A B, treatment coverage C, along multisectoral engagement. This work provides overview Mexico’s response initiative, highlighting its progress, challenges, areas opportunity.

Язык: Английский

Процитировано

0