Heliyon,
Год журнала:
2024,
Номер
10(15), С. e35016 - e35016
Опубликована: Июль 22, 2024
Delays
in
the
diagnosis
and
treatment
of
pulmonary
tuberculosis
(PTB)
can
increase
risk
transmission,
thereby
posing
a
significant
to
public
health.
Early
is
considered
play
crucial
role
eliminating
TB.
Rapid
testing,
active
case
finding,
health
education
are
effective
strategies
for
reducing
delays
(TDDs).
This
study
aimed
quantitatively
compare
impact
TDD
on
incidence
rates
among
student
non-student
groups,
thus
exploring
efficacy
shortening
ending
TB
epidemic
providing
reference
achieving
target
rate
Infectious Diseases of Poverty,
Год журнала:
2024,
Номер
13(1)
Опубликована: Авг. 16, 2024
Abstract
Background
The
co-infection
of
human
immunodeficiency
virus
(HIV)/acquired
immune
deficiency
syndrome
(AIDS)
and
tuberculosis
(TB)
poses
a
significant
clinical
challenge
is
major
global
public
health
issue.
This
study
aims
to
elucidate
the
disease
burden
HIV-TB
in
global,
regions
countries,
providing
critical
information
for
policy
decisions
curb
epidemic.
Methods
ecological
time-series
used
data
from
Global
Burden
Disease
(GBD)
Study
2021.
encompass
numbers
incidence,
prevalence,
mortality,
disability-adjusted
life
year
(DALY),
as
well
age-standardized
incidence
rate
(ASIR),
prevalence
(ASPR),
mortality
(ASMR),
DALY
HIV-infected
drug-susceptible
(HIV-DS-TB),
multidrug-resistant
(HIV-MDR-TB),
extensively
drug-resistant
(HIV-XDR-TB)
1990
estimated
annual
percentage
change
(EAPC)
rates,
with
95%
confidence
intervals
(
CI
s),
was
calculated.
Results
In
2021,
ASIR
HIV-DS-TB
11.59
per
100,000
population
(95%
UI:
0.37–13.05
population),
0.55
0.38–0.81
HIV-MDR-TB,
0.02
0.01–0.03
population)
HIV-XDR-TB.
EAPC
HIV-MDR-TB
HIV-XDR-TB
2021
were
4.71
CI:
1.92–7.59)
13.63
9.44–18.01),
respectively.
ASMR
2.22
1.73–2.74
0.21
0.09–0.39
0.01
0.00–0.03
4.78
1.32–8.32)
10.00
6.09–14.05),
Conclusions
findings
indicate
that
enhancing
diagnostic
treatment
strategies,
strengthening
healthcare
infrastructure,
increasing
access
quality
medical
care,
improving
education
are
essential
combat
co-infection.
Graphical
Infectious Diseases of Poverty,
Год журнала:
2024,
Номер
13(1)
Опубликована: Авг. 19, 2024
Tuberculosis
(TB)
is
a
major
infectious
disease
with
significant
public
health
implications.
Its
widespread
transmission,
prolonged
treatment
duration,
notable
side
effects,
and
high
mortality
rate
pose
severe
challenges.
This
study
examines
the
epidemiological
characteristics
of
TB
globally
across
regions,
providing
scientific
basis
for
enhancing
prevention
control
measures
worldwide.
Journal of Global Health,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 24, 2025
Abstract
Background
Programmatic
interventions
to
increase
the
detection
of
children
with
tuberculosis
(TB)
are
rarely
evaluated
understand
age-
and
sex-specific
completion
rates.
We
applied
modified
TB
screening
treatment
cascade
frameworks
assess
indicators
effective
implementation
by
age
sex
a
program
for
(zero
14
years)
in
Bangladesh.
Methods
implemented
an
intensified
paediatric
119
health
care
facilities
(2018–21).
followed
systematic
verbal
referral
full
evaluation
who
reported
symptoms
or
contact
history
patient
TB.
Further,
we
linked
if
diagnosed
outcomes.
calculated
percentage
children,
sex,
progressing
through
each
step
compared
frequency
using
χ2
tests.
Results
In
total,
screened
552
182
males
461
419
females
2.8%
2.6%
positive
(P
<
0.001).
74.2%
73.9%
underwent
appropriate
=
0.560).
10.3%
11.5%
were
0.008).
100%
initiated
treatment,
97.6%
97.1%
achieved
successful
outcome
0.428).
The
percent
on
screen,
clinically
TB,
generally
increased
age,
some
variability
throughout
(ranges:
1.2–9.1%,
59.8–88.5%,
6.5–21.9%,
respectively).
Conclusions
largest
gap
observed
both
sexes
among
all
ages
was
not
appropriately
despite
positive.
our
research,
highlight
value
identifying
gaps
inform
innovative,
sex-tailored
improve
future
children.
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0317880 - e0317880
Опубликована: Март 10, 2025
Background
For
a
long
time,
eliminating
tuberculosis
(TB)
has
been
an
enormous
challenge
in
global
health.
We
aim
to
use
the
2021
Global
Burden
of
Disease
Study
(GBD
2021)
systematically
analyze
TB
burden
children
and
adolescents.
Methods
used
GBD
retrieve
incidence,
mortality,
disability-adjusted
life
years
(DALYs)
data
among
people
aged
0
to19
204
countries
regions
between
1990
2021.
The
are
reported
as
counts
ratios
per
100,000
analyzed
by
age,
sex,
location
socio-demographic
index
(SDI).
To
quantify
uncertainty
estimations,
we
include
95%
confidence
interval
(CI)
for
each
indicator.
Results
Globally,
under
age
20
decreased
significantly
2019
overall
incidence
adolescents
fell
37.4%,
from
2.21(95%
UI:1.71–2.76)
million
1.38(95%
UI:1.06–1.76)
Sub-Saharan
Africa
had
highest
increase
(302.88,
UI:
227.85-385.33).
age-standardized
rate
(ASIR),
mortality
(ASMR)
DALYs
(ASDR)
females
faster
than
males.
was
higher
5
old
15
19,
showing
bimodal
pattern.
In
addition,
caused
multidrug-resistant
(MDR-TB)
extensively
drug-resistant
(XDR-TB)
have
increased
dramatically
several
areas.
rates
MDR-TB
XDR-TB
Eastern
Europe
0.04(95%
UI:0.02-0.05)
0.02(95%
UI:0.01-0.03)
respectively.
Conclusion
Although
globally,
disease
remains
major
public
health
concern,
especially
with
low
SDI.
accomplish
ultimate
elimination,
should
continue
invest
prevention
control,
expand
health-care
infrastructure
construction,
advance
diagnostic,
preventive,
treatment
technologies.
Science in One Health,
Год журнала:
2024,
Номер
3, С. 100072 - 100072
Опубликована: Янв. 1, 2024
Tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis,
remains
the
second
leading
cause
of
death
from
a
single
infectious
disease
globally
and
poses
significant
economic
clinical
burden
in
world
2022.
Of
particular
concern
is
emergence
drug-resistant
TB,
accounting
for
15%–20%
TB
deaths.
It
imperative
to
delve
into
global
trends
incidence
rate
multidrug-resistant
tuberculosis
(MDR-TB)
extensively
(XDR-TB),
drawing
upon
comprehensive
Global
Burden
Disease
(GBD)
2021
dataset.
From
GBD
2021,
data
on
incidence,
prevalence,
disability-adjusted
life
years
(DALYs),
MDR-TB
XDR-TB
1990
were
collected.
We
calculated
estimated
annual
percentage
changes
age
standardized
(ASIR)
age-standardized
(ASDR),
segmented
age,
sex,
Socio-demographic
Index
(SDI).
The
impacts
various
risk
factors
also
analyzed.
In
there
an
443,680
(95%
uncertainty
interval
[UI]:
259,196–766,545)
incident
cases
MDR-TB,
106,818
UI:
41,612–211,854)
while
24,036
17,144–34,587)
7,946
3,326–14,859)
XDR-TB.
lowest
high
SDI
regions,
whereas
rates
high-middle
regions
higher
than
those
middle
regions.
This
study
reported
2021.
Until
still
serious
problem
low
countries,
especially
high-risk
populations
with
factors.
Controlling
requires
effective
control
strategies
healthcare
systems.
Therapeutic Advances in Drug Safety,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
The
overlap
of
Drug
Reaction
with
Eosinophilia
and
Systemic
Symptoms
(DRESS)
Stevens-Johnson
syndrome
(SJS)
caused
by
antituberculosis
drugs
represents
an
extremely
rare
event.
This
situation
can
manifest
between
2
8
weeks
after
the
first
exposure
to
medication.
these
conditions
lead
atypical
clinical
manifestations,
thus
complicating
early
diagnosis
implementation
treatment.
report
describes
case
a
patient
who
developed
DRESS/SJS
35
days
starting
experienced
severe
skin
systemic
involvement,
that
required
her
admission
monitoring
in
intensive
care
unit.
From
our
experience
this
case,
we
conclude
importance
accurate
timely
using
validated
scoring
systems
such
as
RegiSCAR
confirm
ALDEN
assess
likelihood
drug
causality.
Timely
intervention
corticosteroids
plays
key
role
moderating
exaggerated
immune
response,
helping
alleviate
dermatological
symptoms
prevent
long-term
organ
damage.
In
addition,
availability
safe
therapeutic
alternatives
for
tuberculosis
treatment
allows
more
effective
safer
management
patients.
Pathogens and Immunity,
Год журнала:
2025,
Номер
10(2), С. 1 - 45
Опубликована: Март 2, 2025
In
the
field
of
tuberculosis
and
non-tuberculous
mycobacterial
(NTM)
disease
we
are
looking
back
on
an
exciting
year
2024
with
more
than
10,000
publications
listed
in
PubMed.
Our
aim,
to
review
scientific
literature
2024,
is
challenged
by
enormous
number
publications.
Therefore,
if
your
article
not
included
or
favorite
mycobacteriology
covered,
please
forgive
us.
"Year
Review"
very
much
clinically
oriented
lesser
emphasis
basic
science,
microbiology,
biotechnology.
Members
steering
committee
Tuberculosis
Network
European
Trials
group
(TBnet;
www.tbnet.eu)
report
139
fields
epidemiology,
prevention,
diagnosis,
treatment
NTM
diseases
published
that
found
particularly
important.
We
separately
for
children
adults
provide
a
brief
overview
newer
technologies
diagnostic
pipeline.
Furthermore,
summarize
priorities
research,
development,
implementation,
all
which
represent
perspective
our
combined
clinical
experience.
This
Year
Review
provides
concise
summary
relevant
highlights
2024.
