Elevated C-Reactive Protein in Older Men With Chronic Pain: Association With Plasma Amyloid Levels and Hippocampal Volume DOI Creative Commons
Tyler Bell, Carol E. Franz, Kelsey R. Thomas

и другие.

The Journals of Gerontology Series A, Год журнала: 2024, Номер 79(11)

Опубликована: Авг. 22, 2024

Abstract Background Chronic pain leads to tau accumulation and hippocampal atrophy, which may be moderated through inflammation. In older men, we examined associations of chronic with Alzheimer’s disease (AD)-related plasma biomarkers volume as by systemic Methods Participants were men without dementia. was defined moderate-to-severe in 2+ study waves at average ages 56, 62, 68. At age 68, measured amyloid-beta (Aβ42, n = 871), Aβ40 (n 887), total (t-tau, 841), neurofilament light chain (NfL, 915), serum high-sensitivity C-reactive protein (hs-CRP, 968), a marker A subgroup underwent structural MRI measure 385). Analyses adjusted for medical morbidities, depressive symptoms, opioid use. Results related higher (β 0.25, p .009), but hs-CRP unrelated AD-related (ps > .05). There significant interaction such that both levels had Aβ42 0.36, .001) 0.29, .003). did not interact predict Aβ42/Aβ40, t-tau, or NfL. Furthermore, there interactions associated lower volume, particularly when elevated (hs-CRP × Aβ42: β −0.19, .002; Aβ40: −0.21, .001), regardless status. Conclusions Aβ, especially also elevated. Higher Aβ smaller volumes. pain, accompanied inflammation, elevate the risk neurodegeneration AD-vulnerable regions.

Язык: Английский

Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells DOI Creative Commons

Qiang Zhang,

Guanhu Yang,

Yuan Luo

и другие.

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Июнь 14, 2024

Abstract Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. The chronic neuroinflammation, breaches in blood-brain barrier (BBB), increased levels inflammatory mediators are central to pathogenesis AD. These factors promote penetration immune cells into brain, potentially exacerbating clinical symptoms neuronal death AD patients. While microglia, resident nervous system (CNS), play crucial role AD, recent evidence suggests infiltration cerebral vessels parenchyma peripheral cells, including neutrophils, T lymphocytes, B NK monocytes participate regulation immunity which expected huge future immunotherapy. Given this article seeks offer comprehensive overview their contributions neuroinflammation disease. Understanding these neuroinflammatory response vital for developing new diagnostic markers therapeutic targets enhance diagnosis treatment

Язык: Английский

Процитировано

13
Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022 DOI Creative Commons
Lijie Zhang, Qiuru Yao, Jinjing Hu

и другие.

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 24, 2024

Abstract Background Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between and inflammation. Microglia mainly participate in the inflammatory response brain. Currently, ample evidence has shown that microglia are closely related to occurrence development disease. Objective We opted for bibliometric analysis comprehensively summarize advancements study disease, aiming provide researchers with current trends future research directions. Methods All articles reviews pertaining from 2000 2022 were downloaded through Web Science Core Collection. The results subjected using VOSviewer 1.6.18 CiteSpace 6.1 R2. Results Overall, 7449 publications included. number was increasing yearly. United States published most publications. Harvard Medical School papers all institutions. Journal Alzheimer’s Disease o f Neuroscience journals commonly cited, respectively. Mt Heneka author highest productivity co-citation. After analysis, keywords neuroinflammation, amyloid-beta, inflammation, neurodegeneration. Gut microbiota, extracellular vesicle, dysfunction meta-analysis hotspots at present stage likely continue. Conclusion NLRP3 inflammasome, TREM2, gut mitochondrial dysfunction, exosomes hotspots. relationship microglia-mediated neuroinflammation been focus trend research.

Язык: Английский

Процитировано

10
Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis DOI Creative Commons

Siye Xie,

Qi Wu

Journal of Orthopaedic Surgery and Research, Год журнала: 2024, Номер 19(1)

Опубликована: Май 28, 2024

Sarcopenia is associated with increased morbidity and mortality. The systemic immune-inflammation index (SII) has been correlated to a variety of disorders. present study conducted systematic review meta-analysis investigate the relationship between SII sarcopenia.

Язык: Английский

Процитировано

9
Neurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress DOI Creative Commons
Siying Li,

Zaoyi Wang,

Gang Liu

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 1, 2024

Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including potential combating neurodegenerative diseases. Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol green tea, has emerged as promising therapeutic agent due to its potent antioxidant anti-inflammatory effects. Chronic neuroinflammation oxidative stress are key pathological mechanisms diseases such Alzheimer's disease (AD) Parkinson's (PD). EGCG neuroprotective efficacy scavenging free radicals, reducing attenuating neuroinflammatory processes. This review discusses molecular EGCG's anti-oxidative chronic neuroinflammation, emphasizing effects on autoimmune responses, neuroimmune system interactions, focusing related AD PD. By elucidating action impact processes, this underscores intervention AD, PD, possibly other Overall, emerges natural compound stress, offering novel avenues strategies treatment disorders.

Язык: Английский

Процитировано

9
Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation DOI Creative Commons
Imanuel Lerman,

Yifeng Bu,

Rahul Singh

и другие.

Bioelectronic Medicine, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 20, 2025

Abstract The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulation. Early innovations, such as cardiac pacemakers and deep brain stimulation, paved the way for these sophisticated technologies. This review traces historical technological progression medicine, culminating in emerging potential devices multiple disorders body. We emphasize both invasive techniques, implantable brain, spinal cord autonomic regulation, while we introduce new prospects non-invasive neuromodulation, including focused ultrasound newly developed neurography enabling precise detection titration inflammatory immune responses. case neuromodulation (incorporating splenic stimulation) is presented through its applications conditions sepsis chronic inflammation, illustrating capacity revolutionize personalized healthcare. Today, or have yet be dynamically modulate nervous system function by responding molecular signals; it represents a transformative approach therapeutic interventions major opportunity which may advance. Knowledge gaps remain likely contribute lack available closed loop systems, namely, (1) significant exogenous endogenous noise must filtered out, (2) drift signal due temporal change disease severity and/or therapy induced neuroplasticity, (3) confounding effects (e.g., concurrent medications dysregulate functions). Leveraging continuous feedback adjustments overcome many barriers, next generation stand at forefront precision offering avenues individualized treatment.

Язык: Английский

Процитировано

1
Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome DOI Creative Commons
Jingjing Shen, Yan Wang, Yang Liu

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract The Cri du Chat Syndrome (CdCS), a devastating genetic disorder caused by deletion on chromosome 5p, faces challenges in finding effective treatments and accurate animal models. Using CRISPR‐Cas9, novel CdCS rat model with 2q22 is developed, mirroring common alteration patients. This exhibits pronounced deficits social behavior, cognition, anxiety, accompanied neuronal abnormalities immune dysregulation key brain regions such as the hippocampus medial prefrontal cortex (mPFC). immunostaining RNA‐seq analyses provide new insights into pathogenesis, revealing inflammatory processes. Importantly, it demonstrated that early gene replacement therapy AAV‐ Ctnnd2 alleviates cognitive impairments rats, highlighting potential for intervention. However, effectiveness of this confined to developmental stages does not fully restore all symptoms. findings deepen understanding pathogenesis suggest promising therapeutic directions.

Язык: Английский

Процитировано

1
Caffeine for Prevention of Alzheimer’s Disease: Is the A2A Adenosine Receptor Its Target? DOI Creative Commons
Stefania Merighi,

Alessia Travagli,

Manuela Nigro

и другие.

Biomolecules, Год журнала: 2023, Номер 13(6), С. 967 - 967

Опубликована: Июнь 8, 2023

Alzheimer's disease (AD) is the most prevalent kind of dementia with roughly 135 million cases expected in world by 2050. Unfortunately, current medications for treatment AD can only relieve symptoms but they do not act as disease-modifying agents that stop course AD. Caffeine one widely used drugs today, and a number clinical studies suggest drinking coffee may be good health, especially fight against neurodegenerative conditions such Experimental works conducted "in vivo" vitro" provide intriguing evidence caffeine exerts its neuroprotective effects antagonistically binding to A2A receptors (A2ARs), subset GPCRs are triggered endogenous nucleoside adenosine. This review provides summary scientific data supporting critical role A2ARs play memory loss cognitive decline, well protective benefits neurodegeneration attained caffeine's antagonistic action on these receptors. They novel fascinating target regulating enhancing synaptic activity, achieving symptomatic potentially effects, protecting neurodegeneration.

Язык: Английский

Процитировано

16
Therapeutic Implications of Probiotics in the Gut Microbe-Modulated Neuroinflammation and Progression of Alzheimer’s Disease DOI Creative Commons
Toshiyuki Murai, Satoru Matsuda

Life, Год журнала: 2023, Номер 13(7), С. 1466 - 1466

Опубликована: Июнь 28, 2023

Alzheimer’s disease (AD) is characterized by the accumulation of specific proteins in brain. A recent study revealed that manipulating gut microbiota (GM) significantly reduced tau pathology and neurodegeneration an apolipoprotein E isoform-dependent manner. The resilience a healthy protects it from variety dysbiosis-related pathologies. Convincing evidence has demonstrated roles GM pathogenesis AD, which are partly mediated modified microglial activity Therefore, modulation may be promising therapeutic option for AD prevention. In addition to providing cells with energy affecting maturation, these microbial metabolites appear influence neuronal function. One potential approaches targeting involve using probiotics. Additionally, human its have also become targets developing interventions prevention disorders. Synbiotics postbiotics can used treat modulating GM. addition, physical activity, exercise, fitness being considered as nonpharmacological therapies reduce signaling pathways related neuroinflammation. might strategies health promotion.

Язык: Английский

Процитировано

15
A how-to guide for a precision medicine approach to the diagnosis and treatment of Alzheimer's disease DOI Creative Commons
Gayatri Devi

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Авг. 17, 2023

Article purpose The clinical approach to Alzheimer's disease (AD) is challenging, particularly in high-functioning individuals. Accurate diagnosis crucial, especially given the significant side effects, including brain hemorrhage, of newer monoclonal antibodies approved for treating earlier stages Alzheimer's. Although early treatment more effective, also difficult. Several mimickers AD exist either separately, or conjunction with pathology, adding diagnostic complexity. To illustrate decision-making process, this study includes de-identified cases and reviews underlying etiology pathology available therapies exemplify subtleties. Problem presentation complex varied. Multiple other primary pathologies present phenotypes that can be difficult distinguish from AD. Furthermore, rarely exists isolation, as almost all patients show evidence pathologies, Lewy body argyrophilic grain disease. phenotype progression vary based on regions affected by coexistence severity presence systemic comorbidities such cardiac disease, common co-occurrence psychiatric diagnoses, genetic risk factors. Additionally, symptoms are influenced an individual's reserve cognitive reserve, well timing diagnosis, which depends demographics both patient diagnosing physician, availability biomarkers. Methods optimal biomarker strategy accurately AD, neuropathologic co-morbidities mimickers, medication non-medication-based treatments discussed. Real-life examples loss process illustrative responses. Implications best considered a syndromic disorder, multitude environmental characteristics. existing alone unicorn, there nearly always coexisting pathologies. biomarkers essential. Treatment response variables involved, effective its prevention, requires individualized, precision medicine strategy.

Язык: Английский

Процитировано

14
Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration? DOI Creative Commons
Mirjam Brackhan, Marina Arribas-Blázquez, Isabel Lastres‐Becker

и другие.

Antioxidants, Год журнала: 2023, Номер 12(8), С. 1564 - 1564

Опубликована: Авг. 4, 2023

Although the trigger for neurodegenerative disease process is unknown, relevance of aging stands out as a major risk development neurodegeneration. In this review, we highlighted relationship between different cellular mechanisms that occur consequence and transcription factor nuclear erythroid-2-related 2 (NRF2) connection with TAU protein. We focused on NRF2 in main processes involved neurodegeneration associated aging, such genomic instability, protein degradation systems (proteasomes/autophagy), senescence, stem cell exhaustion, well inflammation. also analyzed effect levels its aggregation spread process. Finally, investigated interconnection alterations signaling pathway both primary secondary tauopathies. All these points highlight possible therapeutic target

Язык: Английский

Процитировано

13