Oxford University Press eBooks, Год журнала: 2025, Номер unknown, С. 565 - 570
Опубликована: Апрель 1, 2025
Abstract This chapter guides the reader on general principles, clinical manifestations, and management of thyroid disease in hospitalized patients.
Язык: Английский
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Май 2, 2024
Gastrointestinal motility symptoms may be closely related to thyroid diseases. Sometimes, such are the only disease-related clue although degree of vary. The exact mechanism action hormones on gastrointestinal is not completely understood, however, a lies in fact that muscle cell receptors can directly acted upon by thyroxines. Both hypo- and hyperthyroidism cause impairment motility, modifying structure function pharynx esophagus, regulating esophageal peristalsis through neuro-humoral interaction. In hyperthyroid patients, alterations postprandial basic electric rhythms have been observed at gastro-duodenal level, often resulting slower gastric emptying. Gastric emptying also delayed hypothyroidism, but an unrelated mucosa-affecting chronic modification pattern. Hyperthyroidism commonly show malabsorption diarrhoea, while hypothyroidism frequently constipation. summary, it stated dysfunction diseases, affecting any segment. Clinically, typical disease manifestations missing, borderline, or concealed because intercurrent sicknesses. Motility-linked problems easily conceal misdetected, underlying dysthyroidism should carefully analyzed. Here, we aim elaborate associations between disorders GI dysmotility common clinical associated with dysmotility.
Язык: Английский
Процитировано
13
PLoS ONE, Год журнала: 2024, Номер 19(1), С. e0296733 - e0296733
Опубликована: Янв. 11, 2024
Background Microbiome-directed therapies are increasingly utilized to optimize thyroid function in both healthy individuals and those with disorders. However, recent doubts have been raised regarding the efficacy of probiotics, prebiotics, synbiotics improving function. This systematic review aimed investigate potential relationship between probiotics/prebiotics by analyzing impact on hormone levels. Methods We conducted a comprehensive meta-analysis randomized controlled trials that investigated effects free triiodothyronine (fT3), thyroxine (fT4), stimulating (TSH), receptor antibody (TRAb) searched for articles from PubMed, Scopus, Web Science, Embase up until April 1st, 2023, without any language restriction. Quantitative data analysis was performed using random-effects model, standardized mean difference (SMD) 95% confidence interval as summary statistics. The methods results were reported according PRISMA2020 statement. Results A total eight included this review. showed no significant alterations TSH (SMD: -0.01, CI: −0.21, 0.20, P = 0.93; I 2 : 0.00%), fT4 0.04, −0.29, 0.21, 0.73; 0.00%) or fT3 0.45, −0.14, 1.03, 0.43; 78.00%), while reduction TRAb levels observed -0.85, -1.54, -0.15, 0.02; 18.00%) following supplementation. No indication publication bias found. Conclusions Probiotics/prebiotics supplementation does not influence levels, but may modestly reduce patients Graves’ disease.
Язык: Английский
Процитировано
8
European Thyroid Journal, Год журнала: 2024, Номер 13(2)
Опубликована: Фев. 20, 2024
Atrial fibrillation (AF) is a common condition with global estimated prevalence of 60 million cases, and the most cardiac complication hyperthyroidism, occurring in 5-15% overtly hyperthyroid patients. Additionally, subclinical hyperthyroidism high-normal free T4 have been associated an increased risk development AF. Hyperthyroidism-related AF reversible cause AF, majority patients spontaneously revert to sinus rhythm 4-6 months during or after restoration euthyroidism. Therefore, restoring thyroid function indispensable element hyperthyroidism-related management. Rate control beta-blockers consists another first-line therapy, reserving cases persistent It still controversial whether independent factor stroke nonvalvular As result, initiating anticoagulation should be guided by clinical thromboembolic score CHA2DS2-VASc same way it applied non-hyperthyroidism-related Treatment novel direct oral anticoagulants appears as beneficial may safer than warfarin In this review, we address epidemiology, prognosis, diagnosis discuss management strategies controversies
Язык: Английский
Процитировано
7
Health Science Reports, Год журнала: 2025, Номер 8(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background and Aims Globally thyroid disorders (TDs) are common health issues including in the Southeast Asian region. The purpose of this study was to ascertain prevalence Bangladeshi population, with a particular focus on frequency, etiology, comorbidity various diseases. Methods A cross‐sectional research design conducted southeastern part Bangladesh. Information regarding prior diagnosis current management TDs obtained through questionnaire. Results Of 300 respondents, 209 were female, 91 male. Females found be more predominant across all categories ( χ 2 = 17.738, p < 0.05). Furthermore, older age group (31–45 years) demonstrated higher frequency problems (OR: 1.320). Specifically, hyperthyroidism identified as most disorder, followed by hypothyroidism, euthyroidism. Hyperthyroidism less males (18.69%) compared females (43.06%), while hypothyroidism prevalent (46.15%) (27.75%). Multiple logistic regression analysis demonstrates that participants family history have significantly chance 2.991, CI: 1.480–6.044, 0.05) having than those without such history. Interestingly, studied population also exhibited rates comorbidities gastritis, diabetes, cardiovascular Conclusion According study's findings, it is advised concentrate educating Bangladeshis about problems, particularly female population. Moreover, healthcare professionals should check elderly patient's conditions consider possibility dysfunction can coexist other conditions.
Язык: Английский
Процитировано
1
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Июнь 7, 2023
Background Coffee is one of the most consumed beverages worldwide, but effects on thyroid are unknown. This study aims to examine association between coffee and function. Methods Participant data (≥ 20 years, n = 6578) for observational were obtained from NHANES 2007-2012. Analysis was performed using weighted linear regression models multiple logistic models. Genetic datasets Hyperthyroidism Hypothyroidism IEU database contained 462,933 European samples. Mendelian randomization (MR) used analysis, inverse variance weighting (IVW) main method analysis. Results In model adjusted other covariates, participants who drank 2-4 cups per day had significantly lower TSH concentrations compared non-coffee drinkers (b=-0.23, 95% CI: -0.30, -0.16), no statistically significant changes in TT4, FT4, TT3 FT3. addition, <2 showed a low risk developing subclinical hypothyroidism. (OR=0.60, 0.41, 0.88) Observational studies MR have demonstrated both that consumption has effect hyperthyroidism Conclusions Our drinking reduced hypothyroidism serum concentrations. not associated with
Язык: Английский
Процитировано
15
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Янв. 19, 2024
Salivary gland hypofunction (SGH) caused by systemic disease, drugs, aging, and radiotherapy for head neck cancer can cause dry mouth, which increases the risk of disorders such as periodontitis, taste disorders, pain burning sensations in dental caries, dramatically reduces quality life patients. To date, treatment SGH is still aimed at relieving patients’ clinical symptoms improving their life, not able to repair regenerate damaged salivary glands. Pluripotent stem cells (PSCs), including embryonic (ESCs), induced pluripotent (iPSCs), extended (EPSCs), are an emerging source cellular therapies that capable unlimited proliferation differentiation into all three germ layers. In recent years, immunomodulatory tissue regenerative effects PSCs, derived cells, paracrine products these have received increasing attention demonstrated promising therapeutic some preclinical studies targeting SGH. This review outlined etiologies available treatments The existing efficacy potential role summarized, with a focus on PSC-derived stem/progenitor (SGS/PCs) mesenchymal (MSCs). this Review, we provide conceptual outline our current understanding PSCs-based therapy its importance treatment, may inform serve design future studies.
Язык: Английский
Процитировано
6
Environmental Research, Год журнала: 2024, Номер 249, С. 118458 - 118458
Опубликована: Фев. 15, 2024
Epidemiological data regarding thyroid diseases are lacking, in particular for occupationally exposed populations. To compare the risk of hypothyroidism and hyperthyroidism between farming activities within complete population French farm managers (FMs). Digital health from retrospective administrative databases, including insurance claims electronic health/medical records, was employed. This cohort spanned entirety (FMs) who had undertaken work at least once 2002 to 2016. Survival analysis with time initial medication reimbursement as timescale used examine association (hazard ratio, HR) 26 specific both treated hyperthyroidism. A distinct model developed each activity, comparing FMs never engaged activity 2016 those had. All analyses were adjusted potential confounders (e.g., age), sensitivity conducted. Among 1088561 (mean age 46.6 [SD 14.1]; 31% females), there 31834 cases (75% females) 620 (67% respectively. The highest risks observed cattle (HR ranging 1.75 2.42) 1.41 1.44). For hypothyroidism, higher also several animal (pig, poultry, rabbit), well fruit arboriculture = 1.22 [1.14–1.31]). lowest involving horses. Sex differences eight activities, being males 1.09 [1.01–1.20]) than females viticulture 0.97 [0.93–1.00]). two times male dairy farmers females. Our findings offer a comprehensive overview disease FM community. Thyroid ailments might not stem single cause but likely arise combined effects various causal agents triggering factors (agricultural exposome). Further investigation into activities—especially cattle—is essential pinpoint that could enhance monitoring agriculture.
Язык: Английский
Процитировано
6
Endocrine, Год журнала: 2023, Номер 83(2), С. 405 - 413
Опубликована: Авг. 15, 2023
Язык: Английский
Процитировано
9
Lupus, Год журнала: 2024, Номер 33(3), С. 223 - 231
Опубликована: Янв. 12, 2024
Objectives Observational studies indicate a significant correlation between systemic lupus erythematosus (SLE) and endocrine metabolic disorders, but the causal association SLE disorders remains unclear due to reverse causality confounding biases commonly presented in conventional observational research. This study endeavors uncover three common including Graves’ disease (GD), type 2 diabetes mellitus (T2DM), osteoporosis (OP). Methods We used genome-wide data for an East Asian population, employing bidirectional two-sample Mendelian randomization (MR) analysis sensitivity ascertain disorders. Results A multiplicative random-effect inverse-variance weighted approach revealed positive elevated risk of GD with odds ratio (OR) 1.12 (95% CI: 1.04–1.22, p < .01), (IVW) also indicated that increased OP OR 1.035 1.003–1.068, .05). Additionally, causally affected IVW after Bonferroni correction, 1.33 1.19–1.49, .05/3), application multivariable MR resulted absence on (OR 1.047, 95% 0.952–1.151, > Lastly, robustness validity findings were verified through analysis. Conclusions confirmed has effect as well OP, no evidence exists substantiate link T2DM. Our offers valuable contributions uncovering etiology furthering research while providing potential targets monitoring therapeutic intervention.
Язык: Английский
Процитировано
3
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(5), С. 103023 - 103023
Опубликована: Апрель 30, 2024
Язык: Английский
Процитировано
3