Trends in oral antibiotic treatment in patients hospitalized with diabetic foot osteomyelitis: a single centre experience DOI

Dylan Rich,

Nick Daneman,

MSc Philip W Lam

и другие.

Journal of the Association of Medical Microbiology and Infectious Disease Canada, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Background: The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial demonstrated the efficacy of highly bioavailable oral antibiotic therapy treatment osteoarticular infections. However, there continues to be significant variability in practice. This study aimed assess changes use diabetic foot osteomyelitis (DFO) at a large academic hospital. Methods: We conducted retrospective cohort adult patients admitted Sunnybrook Health Sciences Centre from January 1, 2016, December 31, 2022, with diagnosis DFO. primary outcome was proportion who received definitive during two timeframes (Pre-OVIVA publication: through Feb 28, 2019, post-OVIVA March Dec 2022). Patients were excluded if they had another indication long-term intravenous antibiotics, did not receive osteomyelitis, or underwent amputation without need postoperative antibiotics. Results: A total 145 included analysis. (65 pre-OVIVA 80 post-OVIVA). majority history peripheral arterial disease (59%) gangrene (66%) present on hospital admission. Use increased 10.8% period 21.2% ( p = 0.14). Conclusions: There trend toward DFO, but overall remained low. Further studies are needed explore factors influencing selection this population.

Язык: Английский

Use of oral antibiotic therapy for prosthetic joint infections: considerations for implementation of interdisciplinary practice changes DOI
Philip W. Lam, Philippe Lagacé‐Wiens, Wayne L. Gold

и другие.

Journal of the Association of Medical Microbiology and Infectious Disease Canada, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

Процитировано

0
Trends in oral antibiotic treatment in patients hospitalized with diabetic foot osteomyelitis: a single centre experience DOI

Dylan Rich,

Nick Daneman,

MSc Philip W Lam

и другие.

Journal of the Association of Medical Microbiology and Infectious Disease Canada, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Background: The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial demonstrated the efficacy of highly bioavailable oral antibiotic therapy treatment osteoarticular infections. However, there continues to be significant variability in practice. This study aimed assess changes use diabetic foot osteomyelitis (DFO) at a large academic hospital. Methods: We conducted retrospective cohort adult patients admitted Sunnybrook Health Sciences Centre from January 1, 2016, December 31, 2022, with diagnosis DFO. primary outcome was proportion who received definitive during two timeframes (Pre-OVIVA publication: through Feb 28, 2019, post-OVIVA March Dec 2022). Patients were excluded if they had another indication long-term intravenous antibiotics, did not receive osteomyelitis, or underwent amputation without need postoperative antibiotics. Results: A total 145 included analysis. (65 pre-OVIVA 80 post-OVIVA). majority history peripheral arterial disease (59%) gangrene (66%) present on hospital admission. Use increased 10.8% period 21.2% ( p = 0.14). Conclusions: There trend toward DFO, but overall remained low. Further studies are needed explore factors influencing selection this population.

Язык: Английский

Процитировано

0