Trends in oral antibiotic treatment in patients hospitalized with diabetic foot osteomyelitis: a single centre experience DOI

Dylan Rich,

Nick Daneman,

MSc Philip W Lam

et al.

Journal of the Association of Medical Microbiology and Infectious Disease Canada, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Background: The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial demonstrated the efficacy of highly bioavailable oral antibiotic therapy treatment osteoarticular infections. However, there continues to be significant variability in practice. This study aimed assess changes use diabetic foot osteomyelitis (DFO) at a large academic hospital. Methods: We conducted retrospective cohort adult patients admitted Sunnybrook Health Sciences Centre from January 1, 2016, December 31, 2022, with diagnosis DFO. primary outcome was proportion who received definitive during two timeframes (Pre-OVIVA publication: through Feb 28, 2019, post-OVIVA March Dec 2022). Patients were excluded if they had another indication long-term intravenous antibiotics, did not receive osteomyelitis, or underwent amputation without need postoperative antibiotics. Results: A total 145 included analysis. (65 pre-OVIVA 80 post-OVIVA). majority history peripheral arterial disease (59%) gangrene (66%) present on hospital admission. Use increased 10.8% period 21.2% ( p = 0.14). Conclusions: There trend toward DFO, but overall remained low. Further studies are needed explore factors influencing selection this population.

Language: Английский

Use of oral antibiotic therapy for prosthetic joint infections: considerations for implementation of interdisciplinary practice changes DOI
Philip W. Lam, Philippe Lagacé‐Wiens, Wayne L. Gold

et al.

Journal of the Association of Medical Microbiology and Infectious Disease Canada, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

Citations

0
Trends in oral antibiotic treatment in patients hospitalized with diabetic foot osteomyelitis: a single centre experience DOI

Dylan Rich,

Nick Daneman,

MSc Philip W Lam

et al.

Journal of the Association of Medical Microbiology and Infectious Disease Canada, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Background: The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial demonstrated the efficacy of highly bioavailable oral antibiotic therapy treatment osteoarticular infections. However, there continues to be significant variability in practice. This study aimed assess changes use diabetic foot osteomyelitis (DFO) at a large academic hospital. Methods: We conducted retrospective cohort adult patients admitted Sunnybrook Health Sciences Centre from January 1, 2016, December 31, 2022, with diagnosis DFO. primary outcome was proportion who received definitive during two timeframes (Pre-OVIVA publication: through Feb 28, 2019, post-OVIVA March Dec 2022). Patients were excluded if they had another indication long-term intravenous antibiotics, did not receive osteomyelitis, or underwent amputation without need postoperative antibiotics. Results: A total 145 included analysis. (65 pre-OVIVA 80 post-OVIVA). majority history peripheral arterial disease (59%) gangrene (66%) present on hospital admission. Use increased 10.8% period 21.2% ( p = 0.14). Conclusions: There trend toward DFO, but overall remained low. Further studies are needed explore factors influencing selection this population.

Language: Английский

Citations

0