Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 20, 2024

Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations the post-acute sequelae SARS-CoV-2. Our understanding metabolic decline after acute COVID-19 remains unclear due to lack animal models. Here, we report a non-human primate model SARS-CoV-2 using infected African green monkeys. Using this model, identify dysregulated blood chemokine signature during that correlates with elevated persistent hyperglycemia four months post-infection. Hyperglycemia also liver glycogen levels, but there is no evidence substantial long-term replication pancreas. Finally, favorable glycemic effect mRNA vaccine, administered on day 4 Together, these data suggest monkey exhibits important similarities humans can be utilized assess therapeutic candidates combat COVID-related defects.

Язык: Английский

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Skeletal muscle adaptations and post-exertional malaise in long COVID

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which the worsening of following mental or physical exertion. There little consensus on pathophysiology exercise-induced PEM skeletal-muscle-related symptoms. In opinion article we highlight intrinsic mitochondrial dysfunction, endothelial abnormalities, a muscle fiber type shift towards more glycolytic phenotype as main contributors to reduced exercise capacity in The mechanistic trigger for induce unknown, but rapid skeletal tissue damage intramuscular infiltration immune cells contribute PEM-related

Язык: Английский

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From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID

Опубликована: Март 30, 2023

Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers various events from molecular to tissue level, which in turn is given by the intrinsic characteristics of each patient. Given diversity characteristic cellular phenotype, possible cytopathic, and clinical effects are difficult predict, determines heterogeneity COVID-19 symptoms. The purpose this article provide a comprehensive review cytopathic SARS-CoV-2 on cell types, focusing development COVID-19, may lead, some patients, persistence symptoms after recovery disease, condition known as long COVID. We describe mechanisms underlying virus-host interactions, including alterations protein expression, intracellular signaling pathways, immune responses. In particular, highlights potential impact these cytopathies function outcomes, such dysregulation, neuropsychiatric disorders, organ damage. concludes discussing future directions for research implications management treatment Long-COVID.

Язык: Английский

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SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons

Journal of NeuroVirology, Год журнала: 2024, Номер 30(1), С. 39 - 51

Опубликована: Янв. 3, 2024

Abstract Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major outbreaks in humans, the latter resulting a global pandemic. While sarbecoviruses primarily cause an acute respiratory infection, they shown to infect nervous system. However, mechanisms of sarbecovirus neuroinvasion neuropathogenesis remain unclear. In this study, we examined infectivity trans-synaptic transmission potential human stem cell–derived neural model systems. We demonstrated limited ability replicate neurons. Furthermore, inability transmit between synaptically connected Finally, determined absence infection olfactory neurons experimentally infected ferrets. Collectively, study indicates that exhibit low neurons, lack ferret inbuilt molecular mechanism utilise retrograde axonal trafficking spread within

Язык: Английский

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Antidepressants with anti-inflammatory properties may be useful in long COVID depression

Drugs & Therapy Perspectives, Год журнала: 2022, Номер 39(2), С. 65 - 70

Опубликована: Дек. 12, 2022

Язык: Английский

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The Aftermath of COVID-19: Exploring Long-Term Effects on the Organ Systems

Опубликована: Апрель 3, 2024

Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) is a complicated disease that affects millions people all over the world. Previous studies have shown PASC impacts 10% infected patients which 50-70% are hospitalized. It has also been 10-12% those vaccinated against COVID-19 were affected with and its complications. The severity later development symptoms positively associated early intensity infection. Results: generated health complications caused by involve vast variety organ systems. Patients diagnosed neuropsychiatric neurological symptoms. Cardiovascular system involved several diseases such as myocarditis, pericarditis, coronary artery reported. Chronic hematological problems thrombotic endothelialitis hypercoagulability described condition could increase risk clotting disorders coagulopathy in patients. Chest pain, breathlessness, cough respiratory long causing distress syndrome. observed immune notable, involving diseases. Renal was impacted result raising issues, fibrosis, sepsis. Endocrine gland malfunction can lead to diabetes, thyroiditis, male infertility. Symptoms diarrhea, nausea, loss appetite taste among reported observations due gastrointestinal disorders. Skin abnormalities might be an indication long-term implications persistent cutaneous complaints linked PASC. Conclusions: Long COVID multidimensional syndrome considerable public implications, affecting physiological systems demanding thorough medical therapy well more study address underlying causes effects.

Язык: Английский

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Cluster analysis of post-COVID-19 physical and mental health outcomes 3–6 months after SARS-CoV-2 infection: results of the French Prospective ALCOVID Cohort Study

BMJ Open, Год журнала: 2025, Номер 15(2), С. e089136 - e089136

Опубликована: Фев. 1, 2025

Objectives This study aims to characterise the diversity of post-COVID-19 physical and mental health outcomes, known as condition (PCC), determining factors 3–6 months after acute SARS-CoV-2 infection. Design is a prospective cohort study. Setting took place at European Hospital Marseille, France. Participants include patients with COVID-19 treated inpatients or outpatients. Interventions face-to-face assessment symptoms. Main outcome measures symptom scores scales, well paraclinical elements (thoracic CT scan, pulmonary functional tests). Multiple component analysis was used identify clinical phenotypic clusters PCC patients, their initial comorbidity groups. A multinomial regression model evaluate association between comorbidities disease severity phenotype. Results total 210 agreed participate, which 157 (75%) reported least one visit; mostly asthenia, dyspnoea, psychiatric disorders such anxiety, depression, post-traumatic stress disorder cognitive disorders. Four were recognised: (1) paucisymptomatic (n=82, 39%); (2) sequelae (n=39, 18.6%), (3) pre-existing (n=29, 13.8%); (4) somatic and/or symptoms (n=60, 28.6%). In addition symptoms, in these differed terms demographic characteristics (sex), COVID-19. Conclusions The four identified corresponded distinct coherent entities, making it possible consider adapted personalised prognosis therapeutic interventions.

Язык: Английский

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A multidisciplinary review of long COVID to address the challenges in diagnosis and updated management guidelines

Annals of Medicine and Surgery, Год журнала: 2025, Номер 87(4), С. 2105 - 2117

Опубликована: Фев. 27, 2025

Long COVID has emerged as a significant challenge since the COVID-19 pandemic, which was declared an outbreak in March 2020, marked by diverse symptoms and prolonged duration of disease. Defined WHO persisting or emerging for at least two months post-SARS-CoV-2 infection without alternative cause, its prevalence varies globally, with estimates 10–20% Europe, 7.3% USA, 3.0% UK. The condition’s etiology remains unclear, involving factors, such renin–angiotensin system overactivation, persistent viral reservoirs, immune dysregulation, autoantibodies. Reactivated viruses, like EBV HSV-6, alongside epigenetic alterations, exacerbate mitochondrial dysfunction energy imbalance. Emerging evidence links SARS-CoV-2 to chromatin gut microbiome changes, further influencing long-term health impacts. Diagnosis long requires detailed systemic evaluation through medical history physical examination. Management is highly individualized, focusing mainly on patient’s affected systems. A multidisciplinary approach essential, integrating perspectives address manifestations, underlying mechanisms, therapeutic strategies. Enhanced understanding COVID’s pathophysiology clinical features critical improving patient outcomes quality life. With growing number cases expected advancing research disseminating knowledge remain vital developing effective diagnostic management frameworks, ultimately supporting better care individuals.

Язык: Английский

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Multitarget-based in silico screening from phytoactive compounds of Garcinia linii fighting toward severe acute respiratory syndrome coronavirus-2

Tzu Chi Medical Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

A BSTRACT Objectives: The recent global coronavirus disease 2019 (COVID-19) pandemic, resulting from infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), can cause and fatal pneumonia along with other life-threatening complications. Materials Methods: rare limited accessibility of approved therapeutic agents or vaccines is great distress. Swiftly working on designing identifying inhibitors against all possible viral key protein targets, seven SARS-CoV-2 enzymes were selected as particularly in the action virus-entry, replication, immune evasion COVID-19. Papain-like protease, main RNA-dependent RNA polymerase, endoribonuclease (nsp15), receptor-binding domain-angiotensin-converting enzyme 2, transmembrane serine protease 2 (TMPRSS2), 2’- O-ribose methyltransferase (2′MTase), which subjected to an unbiased silico screening 22 small molecules originating Garcinia linii concomitantly Remdesivir, Nirmatrelvir, Molnupiravir Food Drug Administration repurposing drugs invasion. Results: results showed that natural bioactive compounds containing α-Tocopheryolquinone, 6β-Hydroxystigmast-4-en-3-one, Squalene, Rutin Quercetin have a high binding affinity targets concurrently preference absorption, distribution, metabolism, excretion, toxicity drug-likeness. Conclusion: This study provides potential phytoactive G . through multi-target screen molecular dynamic simulation for combating COVID-19 pandemics need further experimental validation confirm prospective efficacy.

Язык: Английский

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Impact of COVID-19 Pandemic on Consumption of Anxiolytics, Antipsychotics, and Antidepressants in South Italian Region

Life, Год журнала: 2025, Номер 15(4), С. 652 - 652

Опубликована: Апрель 16, 2025

The COVID-19 lockdown had significant consequences on the mental health of millions people, leading to increasing prescription and use psychotropic drugs. Due lack data in current literature, this study aims estimate trends consumption anxiolytics, antipsychotics, antidepressants before during pandemic people South Italian region. We conducted a retrospective observational study, retrieving prescriptions dispensed pharmacies Basilicata region (South Italy) for period 2019–2021. presented data, expressed Daily Defined Doses (DDDs) 1000 persons/day (DHD), total resident population 95,021, dividing age groups into categories <30, 30–50, 50–70, >70 years. linear regression model examinate across Software XLSTAT was used statistical analysis. During period, more than 85,000 boxes medications were dispensed. research showed an increase sales all three drugs examined, with greater rise benzodiazepines (88.5%) selective serotonin reuptake inhibitors (81.9%) 2021 compared 2019, especially among women under 30 led drugs, confirming impact population’s health.

Язык: Английский

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