Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis
Nature Metabolism,
Год журнала:
2024,
Номер
6(8), С. 1454 - 1478
Опубликована: Авг. 22, 2024
Язык: Английский
Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation
Journal of Food Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Abstract
Sleep
disturbances
are
increasingly
prevalent,
significantly
impacting
physical
and
mental
health.
Recent
research
reveals
a
bidirectional
relationship
between
gut
microbiota
sleep,
mediated
through
the
microbiota–gut–brain
axis.
This
review
examines
role
of
in
sleep
physiology
explores
how
biotics,
including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fermented
foods,
can
enhance
quality.
Drawing
from
animal
human
studies,
we
discuss
neurobiological
mechanisms
by
which
biotics
may
influence
modulation
neurotransmitters,
immune
responses,
hormonal
regulation.
Key
microbial
metabolites,
such
as
short‐chain
fatty
acids,
highlighted
for
their
supporting
sleep‐related
neurochemical
processes.
Additionally,
this
presents
dietary
strategies
food
processing
technologies,
like
fermentation,
innovative
approaches
enhancement.
Although
promising,
available
has
limitations,
small
sample
sizes,
variability
biotic
strains
dosages,
reliance
on
subjective
assessments.
underscores
need
standardized
protocols,
objective
assessments
polysomnography,
personalized
interventions.
Emerging
findings
highlight
therapeutic
potential
improvement,
though
further
large‐scale
trials
essential
to
refine
strain
selection,
dosage,
formulation.
interdisciplinary
exploration
seeks
advance
food‐based
interventions
holistic
managing
disorders
improving
quality
life.
Язык: Английский
Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease Therapeutics
Food Reviews International,
Год журнала:
2025,
Номер
unknown, С. 1 - 27
Опубликована: Март 19, 2025
Язык: Английский
High-cellulose diet ameliorates cognitive impairment by modulating gut microbiota and metabolic pathways in mice
Journal of Nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
A Role for the Microbiota‐Gut‐Brain Axis in Avoidant/Restrictive Food Intake Disorder: A New Conceptual Model
International Journal of Eating Disorders,
Год журнала:
2024,
Номер
57(12), С. 2321 - 2328
Опубликована: Ноя. 14, 2024
Avoidant/restrictive
food
intake
disorder
(ARFID)
is
an
eating
characterized
by
a
severely
restrictive
diet
leading
to
significant
physical
and/or
psychosocial
sequelae.
Largely
owing
the
phenotypic
heterogeneity,
underlying
pathophysiological
mechanisms
are
relatively
unknown.
Recently,
communication
between
microorganisms
within
gastrointestinal
tract
and
brain-the
so-called
microbiota-gut-brain
axis-has
been
implicated
in
pathophysiology
of
disorders.
This
Spotlight
review
sought
investigate
conceptualize
possible
ways
that
axis
involved
ARFID
drive
future
research
this
area.
Язык: Английский
Propionic Acid Impact on Multiple Sclerosis: Evidence and Challenges
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3887 - 3887
Опубликована: Ноя. 14, 2024
Accumulating
evidence
suggests
that
multiple
sclerosis
(MS)
is
an
environmentally
influenced
disorder
with
contributions
from
life-time
exposure
to
factors
including
Epstein–Barr
virus
infection
or
shifts
in
microbiome,
diet
and
lifestyle.
One
suggested
factor
a
deficiency
propionic
acid,
short-chain
fatty
acid
produced
by
gut
bacteria
may
contribute
the
disease
pathology
both
animal
models
human
cases
of
MS.
Propionate
appears
exert
beneficial
effects
on
immune,
peripheral
central
nervous
systems
people
MS
(pwMS),
showing
immunoregulatory,
neuroprotective
neurogenerative
effects.
These
functions
are
crucial,
given
characterized
immune-mediated
damage
myelin
system.
Accordingly,
propionate
supplementation
modulated
increase
its
levels
through
microbiome
help
counteract
pro-inflammatory
state
directly
regulating
immune
system
and/or
decreasing
permeability
barrier
blood–brain
barrier.
This
could
potentially
improve
outcomes
when
used
immune-modulating
therapy.
However,
while
broad
promising,
further
large
clinical
trials
necessary
evaluate
efficacy
safety
pwMS
clarify
role
as
complementary
therapeutic
strategy.
review
provides
comprehensive
analysis
evidence,
challenges
limitations
concerning
Язык: Английский