The
pathogenesis
of
cancer
is
closely
related
to
the
disruption
homeostasis
in
human
body.
gut
microbiome
plays
crucial
roles
maintaining
its
host
throughout
lifespan.
In
recent
years,
a
large
number
studies
have
shown
that
dysbiosis
involved
entire
process
initiation,
development,
and
prognosis
by
influencing
immune
system
metabolism.
Some
specific
intestinal
bacteria
promote
occurrence
development
cancers
under
certain
conditions.
Conversely,
some
other
suppress
oncogenesis
progression
cancers,
including
inhibiting
delaying
boosting
therapeutic
effect
on
cancers.
promoting
effects
been
comprehensively
discussed
previous
review.
This
article
will
review
latest
advances
mechanisms
suppression,
providing
new
perspective
for
developing
strategies
prevention
treatment.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
Background
Dangua
Fang
(DGF)
is
a
traditional
Chinese
herbal
formula
widely
used
to
regulate
glucolipid
metabolism.
Nuclear
factor,
interleukin-3
regulated
(NFIL3)
plays
regulatory
role
in
intestinal
fat
absorption
and
energy
Gut
microbiota
can
modulate
NFIL3
expression
affect
host
Purpose
This
study
aimed
investigate
the
effects
of
DGF
or
inhibition
on
gut
their
metabolites
mice
with
metabolism
disorder
(GLMD)
explore
relationship
between
anti-GLMD
those
direct
inhibition.
Methods
A
GLMD
mouse
model
was
established
by
induction
high-glucose
high-fat
diet.
The
were
divided
into
control
group
(CG),
(MG),
(DFG),
+
siRNA
(DFSG),
(SG).
administered
sterile
water,
DGF,
and/or
intraperitoneal
injections
siRNA-NFIL3
normal
saline
for
15
weeks,
following
which
metabolic
indicators,
levels,
histopathological
alterations
liver
small
tissues
evaluated.
Additionally,
differential
analysed,
linear
regression
analysis
conducted
microbial
species
indicators
assess
regulation.
Results
Significant
differences
observed
CG
MG
groups
various
indicators.
Compared
that
group,
DFG,
DFSG,
SG
significantly
improved,
pathological
morphology
intestine
altered.
mRNA
protein
levels
serum,
liver,
decreased.
relative
abundance
Bacteroidota
decreased,
whereas
Firmicutes
increased,
changes
correlated
serum
total
cholesterol
(TC),
triglyceride
(TG),
free
fatty
acid
(FFA)
levels.
Moreover,
lipid
metabolism-related
pathways
altered
all
three
intervention
groups.
Conclusion
reduced
mice,
metabolites,
pathways,
similar
Nicotinamide
riboside
alleviated
cognitive
impairment
induced
by
sucrose/aspartame,
which
might
be
related
to
neuroinflammation,
pyroptosis,
oxidative
stress,
apoptosis
and
autophagy.
Seminars in Immunopathology,
Год журнала:
2025,
Номер
47(1)
Опубликована: Янв. 27, 2025
Abstract
The
brain-gut
axis
constitutes
the
basis
for
bidirectional
communication
between
central
nervous
system
and
gastrointestinal
tract
driven
by
neural,
hormonal,
metabolic,
immunological,
microbial
signals.
Alterations
in
gut
microbiome
composition
as
observed
inflammatory
bowel
diseases
can
modulate
brain
function
emerging
empirical
evidence
has
indicated
that
interactions
among
microbiome-axis
seem
to
play
a
significant
role
pathogenesis
of
both
psychiatric
disorders
their
comorbidity.
Yet,
immunological
molecular
mechanisms
underlying
co-occurrence
psychological
symptoms
are
still
poorly
understood.
aim
this
narrative
review
is
highlight
contemporary
findings
supporting
pivotal
pathophysiology
highly
prevalent
neuropsychiatric
such
fatigue,
depression,
anxiety.
Finally,
we
focus
on
modulation
potential
treatment
option
comorbid
immune-mediated
especially
diseases.
High-quality
clinical
trials
required
clarify
how
through
dietary
interventions
or
probiotic,
prebiotic
synbiotic
be
used
clinically
improve
mental
health
thus
quality
life
patients
with
