Obesity Facts,
Год журнала:
2023,
Номер
16(3), С. 224 - 236
Опубликована: Янв. 1, 2023
Introduction:
While
the
genetic
and
environmental
underpinnings
of
body
weight
alcohol
use
are
fairly
well-known,
determinants
simultaneous
changes
in
these
traits
still
poorly
known.
We
sought
to
quantify
components
underlying
parallel
consumption
investigate
potential
covariation
between
them.
Methods:
The
analysis
comprised
4,461
adult
participants
(58%
women)
from
Finnish
Twin
Cohort
with
four
measures
mass
index
(BMI)
over
a
36-year
follow-up.
Trajectories
each
trait
were
described
by
growth
factors,
defined
as
intercepts
(i.e.,
baseline)
slopes
change
follow-up),
using
latent
curve
modeling.
Growth
values
used
for
male
(190
monozygotic
pairs,
293
dizygotic
pairs)
female
(316
487
same-sex
complete
twin
pairs
multivariate
variances
covariances
factors
then
decomposed
into
components.
Results:
baseline
heritabilities
similar
men
(BMI:
h2
=
79%
[95%
confidence
interval:
74,
83];
consumption:
49%
[32,
67])
women
(h2
77%
[73,
81];
45%
[29,
61]).
Heritabilities
BMI
52%
[42,
61])
57%
[50,
63]),
but
heritability
was
significantly
higher
(p
0.03)
[34,
54])
than
31%
[22,
38]).
Significant
additive
correlations
at
observed
both
(rA
−0.17
[−0.29,
−0.04])
−0.18
[−0.31,
−0.06]).
Non-shared
affecting
correlated
(rE
0.18
[0.06,
0.30]).
Among
women,
non-shared
inversely
−0.11
[−0.20,
−0.01]).
Conclusions:
Based
on
correlations,
variation
may
affect
consumption.
Independent
effects,
correlates
men,
suggesting
direct
effects
Addiction Science & Clinical Practice,
Год журнала:
2024,
Номер
19(1)
Опубликована: Авг. 2, 2024
Abstract
Background
Substance
use
disorders
(SUDs)
have
been
consistently
shown
to
exhibit
moderate
intergenerational
continuity
(1–3).
While
much
research
has
examined
genetic
and
social
influences
on
addiction,
less
attention
paid
clients’
lay
persons’
perceptions
of
the
heritability
SUD
(4)
implications
for
treatment.
Methods
For
this
qualitative
study,
twenty-six
structured
Working
Model
Child
Interviews
(WMCI)
were
conducted
with
mothers
receiving
inpatient
These
interviews
thematically
analyzed
themes
related
maternal
around
transmission
substance
behaviours.
Results
Findings
show
that
over
half
in
sample
preoccupied
their
children’s
risk
factors
addictions.
Among
group,
29%
spontaneously
expressed
concerns
about
54%
shared
worries
propensity
addiction
without
mentioning
word
gene
or
genetic.
Additionally,
37%
had
challenges
even
discussing
future
when
prompted.
mapped
onto
internal
working
models
attachment
unexpected
ways,
parents
who
coded
balanced
being
more
likely
discuss
disengaged
displaying
difficulties
child’s
future.
Conclusion
This
suggests
dominant
discourse
brain-disease
model
addictions,
its
effort
reduce
stigma
self-blame,
may
unintended
downstream
consequences
parents’
mental
risks
addiction.
Parents
treatment,
staff
deliver
it,
benefit
from
psychoeducation
as
part
BMC Medical Genomics,
Год журнала:
2021,
Номер
14(1)
Опубликована: Авг. 12, 2021
Abstract
Background
With
the
increase
in
cannabis
use
rates,
disorder
is
being
reported
as
one
of
most
common
drug
disorders
globally.
Cannabis
has
several
known
physical,
psychological,
and
social
adverse
events,
such
altered
judgement,
poor
educational
outcomes,
respiratory
symptoms.
The
propensity
for
taking
development
a
may
be
genetically
influenced
some
individuals.
Heritability
estimates
suggest
genetic
basis
use,
genome-wide
association
studies
(GWASs)
have
identified
possible
regions
association,
albeit
with
inconsistent
findings.
This
systematic
review
aims
to
summarize
findings
from
GWASs
investigating
disorder.
Methods
incorporates
articles
that
performed
GWAS
or
MEDLINE,
Web
Science,
EMBASE,
CINAHL,
Catalog,
Central,
NIH
Database
Genotype
Phenotype
were
searched
using
comprehensive
search
strategy.
All
screened
duplicate,
quality
evidence
was
assessed
(Q-Genie)
tool.
underwent
qualitative
synthesis;
however,
quantitative
analysis
not
feasible.
Results
Our
5984
articles.
Six
met
our
eligibility
criteria
included
this
review.
six
results
significance
threshold
p
≤
1.0
×
10
–7
.
In
total
96
variants
identified.
While
meta-analysis
possible,
following
genes,
ANKFN1
,
INTS7
PI4K2B
CSMD1
CST7
ACSS1
SCN9A
associated
use.
These
previously
different
mental
health
conditions,
however
relation
Conclusion
summarized
within
field
research.
summary
serves
inform
future
candidate
gene
replication
efforts.
Systematic
Review
Registration
PROSPERO
CRD42020176016.
Obesity Facts,
Год журнала:
2023,
Номер
16(3), С. 224 - 236
Опубликована: Янв. 1, 2023
Introduction:
While
the
genetic
and
environmental
underpinnings
of
body
weight
alcohol
use
are
fairly
well-known,
determinants
simultaneous
changes
in
these
traits
still
poorly
known.
We
sought
to
quantify
components
underlying
parallel
consumption
investigate
potential
covariation
between
them.
Methods:
The
analysis
comprised
4,461
adult
participants
(58%
women)
from
Finnish
Twin
Cohort
with
four
measures
mass
index
(BMI)
over
a
36-year
follow-up.
Trajectories
each
trait
were
described
by
growth
factors,
defined
as
intercepts
(i.e.,
baseline)
slopes
change
follow-up),
using
latent
curve
modeling.
Growth
values
used
for
male
(190
monozygotic
pairs,
293
dizygotic
pairs)
female
(316
487
same-sex
complete
twin
pairs
multivariate
variances
covariances
factors
then
decomposed
into
components.
Results:
baseline
heritabilities
similar
men
(BMI:
h2
=
79%
[95%
confidence
interval:
74,
83];
consumption:
49%
[32,
67])
women
(h2
77%
[73,
81];
45%
[29,
61]).
Heritabilities
BMI
52%
[42,
61])
57%
[50,
63]),
but
heritability
was
significantly
higher
(p
0.03)
[34,
54])
than
31%
[22,
38]).
Significant
additive
correlations
at
observed
both
(rA
−0.17
[−0.29,
−0.04])
−0.18
[−0.31,
−0.06]).
Non-shared
affecting
correlated
(rE
0.18
[0.06,
0.30]).
Among
women,
non-shared
inversely
−0.11
[−0.20,
−0.01]).
Conclusions:
Based
on
correlations,
variation
may
affect
consumption.
Independent
effects,
correlates
men,
suggesting
direct
effects
