Electroconvulsive therapy increases cortical thickness in depression: A systematic review DOI Creative Commons

Toffanin Tommaso,

Cattarinussi Giulia,

Ghiotto Niccolò

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

Abstract Objective Electroconvulsive therapy (ECT) is one of the most studied and validated available treatments for severe or treatment-resistant depression. However, little known about neural mechanisms underlying ECT treatment. This systematic review aims to critically all structural magnetic resonance imaging studies investigating longitudinal cortical thickness (CT) changes after in patients with unipolar bipolar Methods We performed a search on PubMed, Medline, Embase identify published before April 20, 2023. A total 10 were included. Results The investigations showed widespread increases CT depressed patients, involving mainly temporal, insular, frontal regions. In five studies, non-overlapping set brain areas correlated clinical efficacy ECT. small sample size, heterogeneity terms populations, medications, comorbidities, protocols, lack control group some limit generalizability results. Conclusions Our findings support idea that can increase It remains unclear whether these are related response. Future larger longer follow-up warranted thoroughly address potential role as biomarker response Summations summarizes how affects predominantly affected by temporo-insular An association between antidepressant effect was reported half included studies. Identifying possible associated opens new targets ameliorate protocols. Considerations based numbers considerable patients’ characteristics Most cited did not have randomized design, thus reducing strength evidence supporting causal link changes.

Язык: Английский

Epigenetic mechanisms linking early-life adversities and mental health DOI
Eduardo T. Cánepa, Bruno G. Berardino

Biochemical Journal, Год журнала: 2024, Номер 481(10), С. 615 - 642

Опубликована: Май 9, 2024

Early-life adversities, whether prenatal or postnatal exposure, have been linked to adverse mental health outcomes later in life increasing the risk of several psychiatric disorders. Research on its neurobiological consequences demonstrated an association between exposure adversities and persistent alterations structure, function, connectivity brain. Consistent evidence supports idea that regulation gene expression through epigenetic mechanisms are involved embedding impact early-life experiences genome mediate social environments behavioral phenotypes. In addition, studies from rodent models humans suggest these acquired factors can be transmitted offspring following generations potentially contributing a cycle disease risk. However, one important aspects mechanisms, unlike genetic sequences fixed unchangeable, is although markings long-lasting, they nevertheless reversible. this review, we summarize our current understanding derived malnutrition, maltreatment poverty, with huge pervasive health. We also discuss about transgenerational inheritance mammals experimental data suggesting suitable pharmacological interventions could reverse modifications induced by negative experiences. regard, must accompanied efforts determine causes promote result inequity population.

Язык: Английский

Процитировано

5
Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and genetics DOI Creative Commons
Rachel D. Woodham, Wenyi Xiao,

Yuhan Cui

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Abstract Major depressive disorder (MDD) is a leading cause of disability worldwide, yet its diagnosis relies on clinical symptoms alone. Using machine learning applied to deeply phenotyped, medication-free participants with MDD, we identified two neuroanatomical dimensions. Dimension 2 (D2), compared 1 (D1), was characterized by reductions in grey and white matter associated limited treatment response both antidepressant placebo medications. Validation UK Biobank general population cohort (n = 37,235) confirmed that D2 reduced matter, alongside widespread cognitive impairments, adverse events adulthood childhood, increased self-harm suicide attempts, pro-atherogenic lipid profile, genetic associations neurodegenerative traits. These findings suggest D1 reflect distinct neurobiological mechanisms underlying important implications for outcomes. External validation demonstrated population-based delineated heterogeneity identifying potential biomarkers could aid personalising approaches this debilitating disorder.

Язык: Английский

Процитировано

0
Altered neurovascular coupling in depression with childhood maltreatment DOI

Sangni Liu,

Dandan Fan,

Cancan He

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111348 - 111348

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Transdiagnostic relationships between childhood adversity and cortical thickness of the rostral anterior cingulate cortex DOI Creative Commons
Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Childhood adversity (CA) is the leading preventable risk factor for mental illness. While CA can exacerbate affective symptoms across various psychiatric disorders, its impact on brain morphology, particularly rostral anterior cingulate cortex (rACC), has mainly been studied in specific stress-related such as depression and anxiety disorders. Therefore, we set out to disentangle relationships between CA, psychopathology structure a broader range of We 227 patients with and/or neurodevelopmental disorders 95 healthy controls. focused rACC, this region highly impacted by pivotal role functions The presence was associated decreased left rACC thickness whole sample, independent psychopathology. Additionally, contralateral right psychopathology, having thinner compared controls, which most pronounced group. negatively correlated social anxiety-related concerns, core Finally, our exploratory analyses cortical regions did not reveal any robust effects that survived multiple comparison correction. Taken together, results suggest within group, CA-related thinning may compound affected rACC. This 'double hit' contribute well-established phenomenon leads worse illness trajectory these

Язык: Английский

Процитировано

0
Effects of childhood trauma on brain gray matter volume in patients with panic disorder DOI
Zhen Wang,

Ang Hong,

Chaoyi Wu

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Atrophy of bilateral nucleus accumbens in melancholic depression DOI
Zhaosong Chu,

Lijin Yuan,

Mengxin He

и другие.

Neuroreport, Год журнала: 2023, Номер 34(10), С. 493 - 500

Опубликована: Май 31, 2023

Evidence from previous literature suggests that the nucleus accumbens (NAc), hippocampus, and amygdala play critical roles in reward circuit. Meanwhile, it was also suggested abnormalities circuit might be closely associated with symptom of anhedonia depression. However, few studies have investigated structural alterations NAc, depression as main clinical manifestation. Thus, current study aimed to explore changes subcortical regions among melancholic (MD) patients, especially amygdala, provide a theoretical basis for understanding pathological mechanisms MD. Seventy-two MD 74 nonmelancholic (NMD) 81 healthy controls (HCs) matched sex, age, years education were included study. All participants underwent T1-weighted MRI scans. Subcortical structure segmentation performed using FreeSurfer software. NMD patients had reduced left hippocampal volume compared HCs. only bilateral NAc volumes. Moreover, correlation analyses showed correlations between late insomnia lassitude patients. The may related pathogenesis major depressive disorder (MDD), unique neural mechanism findings suggest future should investigate different pathogenic subtypes MDD further contribute development individualized diagnostic treatment protocols.

Язык: Английский

Процитировано

9
Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls DOI Creative Commons
Florian Thomas‐Odenthal, Kai G. Ringwald, Lea Teutenberg

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Март 29, 2024

Abstract Recurrences of depressive episodes in major disorder (MDD) can be explained by the diathesis-stress model, suggesting that stressful life events (SLEs) trigger MDD individuals with pre-existing vulnerabilities. However, longitudinal neurobiological impact SLEs on gray matter volume (GMV) and its interaction early-life adversity remains unresolved. In 754 participants aged 18–65 years (362 patients; 392 healthy controls; HCs), we assessed associations between (Life Events Questionnaire) whole-brain GMV changes (3 Tesla MRI) during a 2-year interval, using voxel-based morphometry SPM12/CAT12. We also explored potential moderating role childhood maltreatment (Childhood Trauma these associations. Over HCs demonstrated significant reductions middle frontal, precentral, postcentral gyri response to higher levels SLEs, while patients showed no such changes. Childhood did not moderate either group. who had at least one episode compared those not, or HCs, increases associated an increase maltreatment. Our findings indicate distinct HCs. decreases may represent adaptive responses stress, whereas both interval maladaptive changes, neural foundation for model recurrences.

Язык: Английский

Процитировано

3
The dynamic influence of nutrition on prolonged cognitive healthspan across the life course: A perspective review DOI Creative Commons
Curie Kim, Natalia Schilder, Katie Adolphus

и другие.

Neuroscience Applied, Год журнала: 2024, Номер 3, С. 104072 - 104072

Опубликована: Янв. 1, 2024

Cognitive function undergoes a dynamic trajectory across the lifespan, influenced by multifaceted mechanisms encompassing genetics, lifestyle, and environmental factors. This review explores impact of nutrition, specifically energy bioactive components, on cognitive health different life stages. Nutrition plays pivotal role, influencing development, brain function, age-related changes. Understanding these connections offers insights into strategies for extending healthspan. The synthesizes evidence highlighting nuanced effects nutrition cognition throughout life. Notably, age-specific balance emerges as crucial factor in maintaining Different stages exhibit distinct nutritional demands affecting function. Maternal impacts prenatal childhood while heightened glucose adolescence influence long-term health. Midlife witnesses hormonal changes decreased plasticity, old age addressing chronic lifestyle factors restriction. We conclude that it is to recognize diverse requirements biological lifespan deeper mechanistic investigations are vital tailor recommendations optimal all populations lifespan.

Язык: Английский

Процитировано

3
Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity DOI Creative Commons

Mónika Gálber,

Szilvia Anett Nagy, G. Orsi

и другие.

NeuroImage Clinical, Год журнала: 2024, Номер 43, С. 103632 - 103632

Опубликована: Янв. 1, 2024

Childhood maltreatment (CM) is a major risk factor for the development of depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences influence brain architecture, we studied functional connectivity (FC) alterations neural networks depressed patients with, or without history CM. Depressed with severe (n = 18), MDD 19), and matched healthy controls 20) were examined resting state MRI. History was assessed 28-item Trauma Questionnaire. Intra- inter-network FC evaluated using FMRIB Software Library CONN toolbox. We found numerous intra- between maltreated non-maltreated patients. Intra-network differences in default mode, visual auditory networks, cerebellum. Network modelling revealed several connecting mode network executive control, salience cerebellar networks. Increased sensory-motor visual, cerebellar, Relatively small sample size, cross-sectional design, retrospective self-report questionnaire to assess experiences. Our findings confirm that severely display strengths, not only their fronto-limbic circuits, but also sensory-motor, auditory, These may explain individuals typically altered perception are prone develop neurological symptom (conversion disorder) adulthood.

Язык: Английский

Процитировано

3
The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder DOI Creative Commons
Cagdas Türkmen, Haoye Tan, Sarah Gerhardt

и другие.

Addiction Biology, Год журнала: 2024, Номер 29(9)

Опубликована: Сен. 1, 2024

Previous studies have established a connection between adverse childhood experiences (ACE) and alcohol use disorder (AUD), both of which are associated with alterations in grey matter volume (GMV) cortical thickness (CT). The current study aimed to assess the neurobiological impact ACE specifically context AUD, as well role maltreatment type (i.e., abuse or neglect) timing.

Язык: Английский

Процитировано

3