Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(13), С. 2432 - 2444

Опубликована: Июнь 25, 2024

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide health problem that affects the quality of life patients imposes tremendous socioeconomic burden. More than half with chronic also suffer from moderate or severe depression. Due to complex pathogenesis CDS, there are no effective therapeutic drugs available. The lack research on neural circuit mechanisms CDS limits development treatments. purpose this article provide an overview various circuits involved in CDS. Notably, activating some can alleviate and/or depression, while other exacerbate these conditions. Moreover, we discuss current emerging pharmacotherapies for such as ketamine. Understanding may clues novel drug treatments improved management.

Язык: Английский

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Aberrant white matter structural connectivity of nucleus accumbens in patients with major depressive disorder: A probabilistic fibre tracing study

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Neural mechanisms underlying cognitive impairment in depression and cognitive benefits of exercise intervention

Behavioural Brain Research, Год журнала: 2024, Номер 476, С. 115218 - 115218

Опубликована: Сен. 2, 2024

Depression is associated with functional brain impairments, although comprehensive studies remain limited. This study reviews neural mechanisms underlying cognitive impairment in depression and identifies activation abnormalities regions. The also explores the processes of benefits exercise intervention for depression. Executive function including working memory, inhibitory control flexibility are frontal cortex anterior cingulate areas, especially dorsolateral prefrontal cortex. certain impairments reward processing, orbitofrontal cortex, nucleus accumbens other striatal Depressed patients exhibit decreased activity hippocampus during memory function. Physical has been found to enhance function, executive processing by increasing regions brain-derived neurotrophic factor (BDNF) as a nutritional plays key role intervention. documents neurophysiological behind intervention's improved functions. In summary, provides insights into effectiveness treatment.

Язык: Английский

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Disrupted functional connectivity of the striatum in patients with diffuse axonal injury: a resting-state functional MRI study

Neuroreport, Год журнала: 2023, Номер 34(16), С. 792 - 800

Опубликована: Сен. 19, 2023

Diffuse axonal injury (DAI) disrupts the integrity of white matter microstructure and affects brain functional connectivity, resulting in persistent cognitive, behavioral affective deficits. Mounting evidence suggests that altered cortical-subcortical connectivity is a major contributor to cognitive dysfunction. The striatum particularly vulnerable DAI, but has received less attention. This study aimed investigate alteration patterns striatal subdivision connectivity. Twenty-six patients with DAI 27 healthy controls underwent resting-state fMRI scans on 3.0 T scanner. We assessed using seed-based analysis DAI. Furthermore, partial correlation was used measure its clinical association. Compared controls, showed decreased between right inferior ventral frontal gyrus, as well parietal lobule, left superior bilateral cerebellar posterior lobe, dorsal caudal putamen anterior cingulate lobule. Moreover, observed caudate while increased found Correlation analyses regions differences group correlated multiple scoring scales, including cognition, motor function, agitated behavior, anxiety disorders. These findings suggest abnormalities cortico-striatal cerebellar-striatal are enriching our understanding neuropathological mechanisms post-injury disorders providing potential neuroimaging markers for diagnosis treatment

Язык: Английский

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The relationship between brain structure volumes, depressive symptoms and body composition in obese/overweight and normal-/underweight women

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 9, 2024

Язык: Английский

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Disrupted functional connectivity of bilateral nucleus accumbens in major depressive disorder with and without melancholic features

Neuroreport, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Our study aims to explore the differences in functional connectivity nucleus accumbens (NAc) between patients with melancholic depression and non-melancholic (NMD) their relation depression's pathogenesis. We recruited 60 depression, 58 NMD, 80 healthy controls, all matched for gender, age, education. Functional analysis focused on bilateral NAc as region of interest, comparing it whole brain correlating significant clinical scores. Melancholic showed reduced left anterior regions, right temporal frontal areas, compared controls. In contrast, NMD displayed only posterior cingulate cortex. also exhibited increased middle gyrus, unlike patients. The findings suggest that exhibit unique patterns, particularly default mode network prefrontal suggesting atypical reward-circuitry interactions. NAc's connection gyrus may distinguish from NMD.

Язык: Английский

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Effect of Xiaoyaosan on brain volume and microstructure diffusion changes to exert antidepressant-like effects in mice with chronic social defeat stress

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Сен. 19, 2024

Objective Depression is a prevalent mental disorder characterized by persistent negative mood and loss of pleasure. Although there are various treatment modalities available for depression, the rates response remission remain low. Xiaoyaosan (XYS), traditional Chinese herbal formula with long history use in treating has shown promising effects. However, underlying mechanism its therapeutic action remains elusive. The aim this study to investigate neuroimaging changes brain associated antidepressant-like effects XYS. Methods Here, we combined voxel-based morphometry T2-weighted images analysis on diffusion tensor evaluate alterations microstructure between chronic social defeat stress (CSDS) model mice control mice. Additionally, examined effect XYS structural disruptions brains XYS-treated Furthermore, explored 18β-glycyrrhetinic acid (18β-GA), which was identified as primary compound present following administration Significant differences structure were utilized classification features distinguishing depression form controls using machine learning method. Results volume metrics observed CSDS mice, primarily concentrated nucleus accumbens (ACB), somatosensory area (SSP), thalamus (TH), hypothalamus (HY), basomedical amygdala (BMA), caudoputamen (CP), retrosplenial (RSP). both 18β-GA prevented certain regions, including bilateral HY, right SSP, ACB, CP, left TH. models based each type feature achieved high accuracy levels (gray matter volume: 76.39%, AUC=0.83; white AUC=0.92; fractional anisotropy: 82.64%, AUC=0.9; radial diffusivity: AUC=0.82). Among these analyses, CP most important regions purposes. Conclusion These findings suggested that can prevent abnormal within TH, exert prophylactic demonstrate excellent performance classifying from while providing valuable insights into antidepressant

Язык: Английский

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Neural correlates of anhedonia in young adults with subthreshold depression: A graph theory approach for cortical-subcortical structural covariance

Journal of Affective Disorders, Год журнала: 2024, Номер 366, С. 234 - 243

Опубликована: Авг. 30, 2024

Anhedonia is an enduring symptom of subthreshold depression (StD) and predict later onset major depressive disorder (MDD). Brain structural covariance describes the inter-regional distribution morphological changes compared to healthy controls (HC) reflects brain maturation disease progression. We investigated neural correlates anhedonia from covariance. T1-weighted magnetic resonance images were acquired 79 young adults (26 StD, 30 MDD, 23 HC). Intra-individual networks 68 cortical surface area (CSAs), thicknesses (CTs), 14 subcortical volumes constructed. Group-level hubs principal edges defined using global regional graph metrics, between groups, examined for association with severity. Global network metrics comparable among HC. StD exhibited lower centralities left pallidal volume than showed higher HC in CSAs right rostral anterior cingulate cortex (ACC) pars triangularis, CT orbitalis. Less was associated pallidum amygdala, edge betweenness (EBSC) postcentral gyrus-parahippocampal gyrus LIPL-right amygdala. More inferior parietal lobule (LIPL), gyrus, caudal ACC, EBSC LIPL-left lateral occipital ACC-parahippocampal gyrus. This study has a cross-sectional design. Structural morphologies within salience limbic networks, salience-limbic-default mode-somatomotor-visual are possible depression.

Язык: Английский

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Lifetime depression, sleep disruption and brain structure in the UK Biobank cohort

Journal of Affective Disorders, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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