Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 273 - 287
Опубликована: Июнь 1, 2024
Язык: Английский
Advanced Materials, Год журнала: 2021, Номер 33(26)
Опубликована: Май 19, 2021
Abstract A major challenge in vaccine delivery is to achieve robust lymph‐node (LN) accumulation, which can capitalize on concentrated immunocytes and cytokines LNs stimulate the onset persistence of adaptive immune responses. Previous attempts at developing systems have focused sizes, charges, or surface ligands but not their deformability. In fact, LN homing antigen‐presenting cells depends deformability pass through cellular gaps. Herein, albumin‐stabilized emulsions engineered. Owing self‐adaptive deformability, droplets (≈330 nm) attach deform between adjust sizes endothelial gaps (20–100 nm), favoring direct transfer (intercellular pathway). Additionally, owing relatively large some be retained administration sites for potent antigen uptake activation APCs as well LN‐targeted vaccines (intracellular Compared with solid particles, dual strategy evidently enhances accumulation drainage, potently stimulates responses, increases survival rate tumor‐bearing mice. Thus, may offer an efficient targeting enhanced vaccinations.
Язык: Английский
Процитировано
71
Science Advances, Год журнала: 2022, Номер 8(47)
Опубликована: Ноя. 23, 2022
Cancer vaccines have attracted widespread interest in tumor therapy because of the potential to induce an effective antitumor immune response. However, many challenges including weak immunogenicity, off-target effects, and immunosuppressive microenvironments prevented their broad clinical translation. To overcome these difficulties, delivery systems been designed for cancer vaccines. As carriers vaccine systems, hydrogels gained substantial attention they can encapsulate a variety antigens/immunomodulators protect them from degradation. This enables simultaneously reverse immunosuppression stimulate Meanwhile, controlled release properties allow precise temporal spatial loads situ further enhance response Therefore, this review summarizes classification vaccines, highlights strategies hydrogel-based provides some insights into future development
Язык: Английский
Процитировано
66
Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(17), С. 9467 - 9473
Опубликована: Янв. 19, 2021
Abstract The search for vaccines that protect from severe morbidity and mortality because of infection with acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus causes disease 2019 (COVID‐19) is a race against clock virus. Here we describe an amphiphilic imidazoquinoline (IMDQ‐PEG‐CHOL) TLR7/8 adjuvant, consisting conjugated to chain end cholesterol‐poly(ethylene glycol) macromolecular amphiphile. It water‐soluble exhibits massive translocation lymph nodes upon local administration through binding albumin, affording localized innate immune activation reduction in systemic inflammation. adjuvanticity IMDQ‐PEG‐CHOL was validated licensed vaccine setting (quadrivalent influenza vaccine) experimental trimeric recombinant SARS‐CoV‐2 spike protein vaccine, showing robust IgG2a IgG1 antibody titers mice could neutralize viral vitro vivo mouse model.
Язык: Английский
Процитировано
63
Biomaterials, Год журнала: 2022, Номер 284, С. 121489 - 121489
Опубликована: Март 25, 2022
Язык: Английский
Процитировано
60
Frontiers in Pharmacology, Год журнала: 2022, Номер 13
Опубликована: Июнь 3, 2022
The lymphatics transport material from peripheral tissues to lymph nodes, where immune responses are formed, before being transported into systemic circulation. With key roles in and fluid homeostasis, lymphatic dysregulation is linked diseases, including lymphedema. Fluid within the interstitium passes initial vessels a valve system prevents backflow. Additionally, endothelial cells produce chemokines, such as CCL21, that direct migration of dendritic lymphocytes. As result, an attractive delivery route for transporting modulatory treatments nodes immunotherapies potentiated addition alternative method reaching In this review, we discuss physiology mechanisms used materials nodes. We then summarize nanomaterial-based strategies take advantage functions delivering therapeutics or also describe opportunities targeting modulate functions.
Язык: Английский
Процитировано
47
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июль 23, 2023
Abstract Therapeutic tumor vaccines have attracted considerable attention in the past decade; they can induce regression, eradicate minimal residual disease, establish lasting immune memory and avoid non-specific adverse side effects. However, challenge field of therapeutic is ensuring delivery components to lymph nodes (LNs) activate cells. The clinical response rate traditional falls short expectations due inadequate node delivery. With rapid development nanotechnology, a large number nanoplatform-based LN-targeting nanovaccines been exploited for optimizing immunotherapies. In addition, some possess non-invasive visualization performance, which benefit understanding kinetics nanovaccine exposure LNs. Herein, we present parameters nanoplatforms, such as size, surface modification, shape, deformability, affect functions nanovaccines. recent advances nanoplatforms with different promoting are also summarized. Furthermore, emerging LNs-targeting nanoplatform-mediated imaging strategies both improve targeting performance enhance quality LN discussed. Finally, summarize prospects challenges /or strategies, optimize efficacy
Язык: Английский
Процитировано
32
Cell Host & Microbe, Год журнала: 2023, Номер 31(11), С. 1882 - 1897.e10
Опубликована: Окт. 16, 2023
Язык: Английский
Процитировано
30
ACS Nano, Год журнала: 2023, Номер 17(2), С. 843 - 884
Опубликована: Янв. 4, 2023
Immunotherapy continues to be in the spotlight of oncology therapy research past few years and has been proven a promising option modulate one's innate adaptive immune systems for cancer treatment. However, poor delivery efficiency agents, potential off-target toxicity, nonimmunogenic tumors significantly limit its effectiveness extensive application. Recently, emerging biomaterial-based drug carriers, including but not limited cells bacteria, are expected candidates break dilemma immunotherapy, with their excellent natures intrinsic tumor tropism immunomodulatory activity. More than that, tiny vesicles physiological components derived from them have similar functions source due inheritance various surface signal molecules proteins. Herein, we presented representative examples about latest advances employed cells, derivatives. Simultaneously, opportunities challenges bacteria-based carriers discussed provide reference future application immunotherapy.
Язык: Английский
Процитировано
28
Science China Chemistry, Год журнала: 2023, Номер 66(4), С. 1150 - 1160
Опубликована: Фев. 24, 2023
Язык: Английский
Процитировано
27
Research, Год журнала: 2023, Номер 6
Опубликована: Янв. 1, 2023
Cancer immunotherapy has achieved tremendous successful clinical results and obtained historic victories in tumor treatments. However, great limitations associated with feeble immune responses serious adverse effects still cannot be neglected due to the complicated multifactorial etiology pathologic microenvironment tumors. The rapid development of nanomedical science material facilitated advanced progress engineering biomaterials tackle critical issues. supramolecular flexible modular structures have exhibited unparalleled advantages high cargo-loading efficiency, excellent biocompatibility, diversiform immunomodulatory activity, thereby providing a powerful weapon for cancer immunotherapy. In past decades, were extensively explored as versatile delivery platforms immunotherapeutic agents or designed interact key moleculars system precise controllable manner. this review, we focused on crucial role modulation pivotal steps during immunotherapy, including antigen presentation, T lymphocyte activation, tumor-associated macrophage elimination repolarization, myeloid-derived suppressor cell depletion. Based extensive research, current prospects
Язык: Английский
Процитировано
27