Advanced Functional Materials,
Год журнала:
2023,
Номер
33(18)
Опубликована: Фев. 20, 2023
Abstract
Orthogonal
upconversion
with
color‐switchable
emissions
under
different
excitation
conditions
provides
new
chances
to
diverse
frontier
applications
of
luminescent
materials.
However,
the
previous
orthogonal
systems
compulsorily
require
precise
control
spatial
distributions
dopants
and
host
compositions
avoid
spectral
cross‐talk,
greatly
limiting
their
synthesis
application.
Herein,
a
conceptual
design
is
presented
realize
by
selectively
activating
sensitizers
activators
in
nanostructure.
In
detail,
915
nm
laser,
instead
mostly
used
980
nm,
adopted
activate
sensitizer
Yb
3+
because
broad
2
F
5/2
←
7/2
absorption
band;
while
it
non‐responsive
Er
,
consequently
avoiding
cross‐talk
due
simultaneous
activation
both
irradiation
as
shown
works.
Such
selective
strategy
able
red/green,
blue/red,
blue/green
single
nanoparticle
simply
altering
wavelength
from
1530
nm.
More
interestingly,
further
allows
for
full‐color
output
temporal
dynamics.
The
findings
suggest
facile
but
effective
approach
smart
materials,
showing
great
potential
multi‐level
anti‐counterfeiting,
information
security
biological
applications.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
145(3), С. 1678 - 1685
Опубликована: Дек. 27, 2022
DNAzyme-based
sensors
remain
at
the
forefront
of
metal-ion
imaging
efforts,
but
most
lack
subcellular
precision
necessary
to
their
applications
in
specific
organelles.
Here,
we
seek
overcome
this
limitation
by
presenting
a
biosensor
technology
for
spatiotemporally
controlled
metal
ions
mitochondria.
A
DNA
nanodevice
was
constructed
integrating
an
optically
activatable
DNAzyme
sensor
and
upconversion
nanoparticle
with
organelle-targeting
signal.
We
exemplify
that
approach
allows
mitochondria-specific
Zn2+
living
cells
near-infrared
light-controlled
manner.
Based
on
this,
system
is
used
monitoring
mitochondrial
during
drug
treatment
cellular
model
ischemia
insult.
Furthermore,
employed
assess
dynamic
change
pharmacological
interventions
injury
cell
toxicity.
This
method
paves
way
engineering
investigate
pathophysiological
roles
level.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(32)
Опубликована: Июнь 6, 2022
DNA-based
biosensor
technologies
have
shown
great
potential
in
chemical
and
biological
detection.
These
biosensors
been
actively
developed
as
probes
for
molecular
imaging
live
cells
animals,
allowing
situ
detection
of
analytes
complex
systems,
elucidation
the
roles
key
molecules
processes,
development
non-invasive
diagnosis
image-guided
surgery.
Despite
progress
made,
improving
spatial-temporal
precision
remains
a
challenge
this
field.
In
Minireview,
we
describe
concepts
behind
spatiotemporally
selective
via
combination
engineered,
light-activatable
upconversion
nanotechnology.
We
then
highlight
application
approach
controlled
various
targets
specific
intracellular
organelles,
signal
amplification,
well
regulation
targeting
activity
to
receptor
proteins.
finally
discuss
challenges
perspectives
possible
future
developments
emerging
ACS Nano,
Год журнала:
2023,
Номер
17(10), С. 9529 - 9542
Опубликована: Май 8, 2023
Hepatic
ischemia–reperfusion
(I/R)
injury
accompanied
by
oxidative
stress
is
responsible
for
postoperative
liver
dysfunction
and
failure
of
surgery.
However,
the
dynamic
non-invasive
mapping
redox
homeostasis
in
deep-seated
during
hepatic
I/R
remains
a
great
challenge.
Herein,
inspired
intrinsic
reversibility
disulfide
bond
proteins,
kind
reversible
redox-responsive
magnetic
nanoparticles
(RRMNs)
designed
imaging
both
oxidant
antioxidant
levels
(ONOO–/GSH),
based
on
sulfhydryl
coupling/cleaving
reaction.
We
develop
facile
strategy
to
prepare
such
MRI
nanoprobe
via
one-step
surface
modification.
Owing
significant
change
size
response,
sensitivity
RRMNs
greatly
improved,
which
enables
monitor
tiny
injury.
Notably,
can
non-invasively
visualize
tissue
slice
living
mice.
Moreover,
this
not
only
report
molecular
information
about
degree
but
also
provide
anatomical
where
pathology
occurred.
The
probe
promising
accurately
facilely
monitoring
process,
accessing
developing
powerful
precise
treatment.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(18)
Опубликована: Фев. 20, 2023
Abstract
Orthogonal
upconversion
with
color‐switchable
emissions
under
different
excitation
conditions
provides
new
chances
to
diverse
frontier
applications
of
luminescent
materials.
However,
the
previous
orthogonal
systems
compulsorily
require
precise
control
spatial
distributions
dopants
and
host
compositions
avoid
spectral
cross‐talk,
greatly
limiting
their
synthesis
application.
Herein,
a
conceptual
design
is
presented
realize
by
selectively
activating
sensitizers
activators
in
nanostructure.
In
detail,
915
nm
laser,
instead
mostly
used
980
nm,
adopted
activate
sensitizer
Yb
3+
because
broad
2
F
5/2
←
7/2
absorption
band;
while
it
non‐responsive
Er
,
consequently
avoiding
cross‐talk
due
simultaneous
activation
both
irradiation
as
shown
works.
Such
selective
strategy
able
red/green,
blue/red,
blue/green
single
nanoparticle
simply
altering
wavelength
from
1530
nm.
More
interestingly,
further
allows
for
full‐color
output
temporal
dynamics.
The
findings
suggest
facile
but
effective
approach
smart
materials,
showing
great
potential
multi‐level
anti‐counterfeiting,
information
security
biological
applications.
